Cited by 165Cardiac Ischemia and ReperfusionCardiovascular Function and Risk FactorsPeroxisome Proliferator-Activated Receptors

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart

Open access

Sidell, Robert J., Cole, Mark A., Draper, Nicholas J., Desrois, Martine, Buckingham, Robin E., Clarke, Kieran·2002·Diabetes

DOI 10.2337/diabetes.51.4.1110

Open this paper in CoChat — free account Open PDF

Abstract

Obesity is associated with risk factors for cardiovascular disease, including insulin resistance, and can lead to cardiac hypertrophy and congestive heart failure. Here, we used the insulin-sensitizing agent rosiglitazone to investigate the cellular mechanisms linking insulin resistance in the obese Zucker rat heart with increased susceptibility to ischemic injury. Rats were treated for 7 or 14 days with 3 mg/kg per os rosiglitazone. Hearts were isolated and perfused before and during insulin stimulation or during 32 min low-flow ischemia at 0.3 ml · min−1 · grams wet wt−1 and reperfusion. d[2-3H]glucose was used as a tracer of glucose uptake, and phosphorus-31 nuclear magnetic resonance spectroscopy was used to follow energetics during ischemia. At 12 months of age, obese rat hearts were insulin resistant with decreased GLUT4 protein expression. During ischemia, glucose uptake was lower and depletion of ATP was greater in obese rat hearts, thereby significantly impairing recovery of contractile function during reperfusion. Rosiglitazone treatment normalized the insulin resistance and restored GLUT4 protein levels in obese rat hearts. Glucose uptake during ischemia was also normalized by rosiglitazone treatment, thereby preventing the greater loss of ATP and restoring recovery of contractile function to that of lean rat hearts. We conclude that rosiglitazone treatment, by normalizing glucose uptake, protected obese rat hearts from ischemic injury.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/diabetes.51.4.1110

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Spiegelman, B. M. (1998) · Diabetes · doi:10.2337/diabetes.47.4.507 · Cited by 1,730
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311
Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
Vidal‐Puig, A., Considine, R. V., Jimenez‐Liñan, M., Werman, A., Pories, W. J., Caro, J. F., & Flier, J. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119424 · Cited by 785
Obesity in the new millennium
Friedman, J. M. (2000) · Nature · doi:10.1038/35007504 · Cited by 709
Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists
Olefsky, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10843 · Cited by 536
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
Goodyear, L. J., Giorgino, F., Sherman, L., Carey, J., Smith, R. J., & Dohm, G. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117909 · Cited by 527
Enzymatic analysis; a practical guide
(1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90404-l · Cited by 522
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diabetes.46.1.3 · Cited by 479
Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice
Yet, S., Tian, R., Layne, M. D., Wang, Z. Y., Maemura, K., Solovyeva, M., Ith, B., Melo, L. G., Zhang, L., Ingwall, J. S., et al. (2001) · Circulation Research · doi:10.1161/hh1401.093314 · Cited by 420
Protons in ischemia: Where do they come from; Where do they go to?
Dennis, S. C. (1991) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(91)91642-5 · Cited by 344
Troglitazone action is independent of adipose tissue.
Burant, C., Sreenan, S., Hirano, K., Tai, T. A., Lohmiller, J. J., Lukens, J. N., Davidson, N. O., Ross, S. R., & Graves, R. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119839 · Cited by 331
Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study.
Gastaldelli, A., Baldi, S., Pettiti, M., Toschi, E., Camastra, S., Natali, A., Landau, B. R., & Ferrannini, E. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1367 · Cited by 320
Enzymatic Analysis
Passonneau, J. V., & Lowry, O. H. (1993) · Humana Press eBooks · doi:10.1007/978-1-60327-407-4 · Cited by 300
In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-γ Agonist Rosiglitazone
Yue, T.-L., Chen, J., Bao, W., Narayanan, P. K., Bril, A., Jiang, W., Lysko, P. G., Gu, J.-L., Boyce, R., Zimmerman, D. M., et al. (2001) · Circulation · doi:10.1161/hc4601.099403 · Cited by 295
Self-citation
Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase
Kanai, F., Ito, K., Todaka, M., Hayashi, H., Kamohara, S., Ishii, K., Okada, T., Hazeki, O., Ui, M., & Ebina, Y. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2111 · Cited by 281
Responses of GLUT4-Deficient Hearts to Ischemia Underscore the Importance of Glycolysis
Tian, R., & Abel, E. D. (2001) · Circulation · doi:10.1161/01.cir.103.24.2961 · Cited by 233
A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat
Oakes, N. D., Kennedy, C. J., Jenkins, A. B., Laybutt, D. R., Chisholm, D. J., & Kraegen, E. W. (1994) · Diabetes · doi:10.2337/diab.43.10.1203 · Cited by 224
Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats
Anai, M., Funaki, M., Ogihara, T., Terasaki, J., Inukai, K., Katagiri, H., Fukushima, Y., Yazaki, Y., Kikuchi, M., Oka, Y., et al. (1998) · Diabetes · doi:10.2337/diab.47.1.13 · Cited by 180
Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action
Loviscach, M., Rehman, N., Carter, L., Mudaliar, S. R. D., Mohadeen, P., Ciaraldi, T. P., Veerkamp, J. H., & Henry, R. R. (2000) · Diabetologia · doi:10.1007/s001250050048 · Cited by 176
Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts.
Owen, P., Dennis, S. C., & Opie, L. H. (1990) · Circulation Research · doi:10.1161/01.res.66.2.344 · Cited by 171
Is a High Glycogen Content Beneficial or Detrimental to the Ischemic Rat Heart?
Cross, H. R., Opie, L. H., Radda, G. K., & Clarke, K. (1996) · Circulation Research · doi:10.1161/01.res.78.3.482 · Cited by 168
Self-citation
Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter.
Kim, H. I., Kim, J. W., Kim, S. H., Cha, J.-Y., Kim, K., & Ahn, Y. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1517 · Cited by 119
Regulation of GLUT4 Gene Expression by Arachidonic Acid
Long, S. D., & Pekala, P. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.1138 · Cited by 112
The missing link with obesity?
Flier, J. S. (2001) · Nature · doi:10.1038/35053251 · Cited by 108
Preconditioning Enhanced Glucose Uptake Is Mediated by p38 MAP Kinase Not by Phosphatidylinositol 3-Kinase
Tong, H., Chen, W., London, R. E., Murphy, E., & Steenbergen, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11981 · Cited by 91
Troglitazone Improves Recovery of Left Ventricular Function After Regional Ischemia in Pigs
Zhu, P., Li, L., Xu, Y., & Schwartz, G. G. (2000) · Circulation · doi:10.1161/01.cir.101.10.1165 · Cited by 90
Activators of peroxisome proliferator-activated receptor-γ (PPARγ) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells
Kitamura, Y., Kakimura, J., Matsuoka, Y., Nomura, Y., Gebicke‐Haerter, P. J., & Taniguchi, T. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00055-5 · Cited by 82
Is Lactate-induced Myocardial Ischaemic Injury Mediated by Decreased pH or Increased Intracellular Lactate?
Cross, H. R., Clarke, K., Opie, L. H., & Radda, G. K. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1995.0130 · Cited by 82
Self-citation
Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats
Kolter, T., Uphues, I., & Eckel, J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e59 · Cited by 78
Glucose delivery is a major determinant of glucose utilisation in the ischemic myocardium with a residual coronary flow
King, L. M., & Opie, L. H. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00100-x · Cited by 75
Effects of wortmannin on insulin- and ischemia-induced stimulation of GLUT4 translocation and FDG uptake in perfused rat hearts
Egert, S. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00133-8 · Cited by 75
Comparative studies on fatty acid synthesis, glycogen metabolism, and gluconeogenesis by hepatocytes isolated from lean and obese Zucker rats
McCune, S. A., Durant, P. J., Jenkins, P. A., & Harris, R. A. (1981) · Metabolism · doi:10.1016/0026-0495(81)90037-8 · Cited by 70
Acute and chronic effects of troglitazone (CS-045) on isolated rat ventricular cardiomyocytes
Bähr, M., Spelleken, M., Bock, M., von Holtey, M., Kiehn, R., & Eckel, J. (1996) · Diabetologia · doi:10.1007/s001250050509 · Cited by 70
Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
Anai, M., Funaki, M., Ogihara, T., et al. (1998) · Diabetes · doi:10.2337/diabetes.47.1.13 · Cited by 62
Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins
Uphues, I., Kolter, T., Goud, B., & Eckel, J. (1995) · Biochemical Journal · doi:10.1042/bj3110161 · Cited by 59
Cellular and molecular regulation of cardiac glucose transport
Young, L. H., Coven, D. L., & Russell, R. R. (2000) · Journal of Nuclear Cardiology · doi:10.1016/s1071-3581(00)70016-x · Cited by 55
α-Adrenergic Stimulation Mediates Glucose Uptake Through Phosphatidylinositol 3-Kinase in Rat Heart
Doenst, T., & Taegtmeyer, H. (1999) · Circulation Research · doi:10.1161/01.res.84.4.467 · Cited by 54
Endogenous glucose production, gluconeogenesis and liver glycogen concentration in obese non-diabetic patients
Müller, C., Assimacopoulos‐Jeannet, F., Mosimann, F., Schneiter, P., Riou, J. P., Pachiaudi, C., Felber, J. P., Jéquier, E., Jeanrenaud, B., & Tappy, L. (1997) · Diabetologia · doi:10.1007/s001250050701 · Cited by 53
Protection of ischemic hearts by high glucose is mediated, in part, by GLUT-4
Ramasamy, R., Hwang, Y. C., Whang, J., & Bergmann, S. R. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.1.h290 · Cited by 50
Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats
Shimabukuro, M., Higa, S., Shinzato, T., Nagamine, F., Komiya, I., & Takasu, N. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90018-9 · Cited by 43
Cardiovascular abnormalities associated with human and rodent obesity
Paulson, D. J., & Tahiliani, A. G. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90618-y · Cited by 40
The New Antidiabetic Drug MCC-555 Acutely Sensitizes Insulin Signaling in Isolated Cardiomyocytes
Liu, L. S., Tanaka, H., Ishii, S., & Eckel, J. (1998) · Endocrinology · doi:10.1210/endo.139.11.6310 · Cited by 38
In Vivo Insulin Signaling in the Myocardium of Streptozotocin-Diabetic Rats: Opposite Effects of Diabetes on Insulin Stimulation of Glycogen Synthase and c-Fos
Wang, P. H., Almahfouz, A., Giorgino, F., McCowen, K. C., & Smith, R. J. (1999) · Endocrinology · doi:10.1210/endo.140.3.6595 · Cited by 32
Free fatty acids, but not ketone bodies, protect diabetic rat hearts during low-flow ischemia
King, L. M., Sidell, R. J., Wilding, J. R., Radda, G. K., & Clarke, K. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.3.h1173 · Cited by 30
Self-citation
Dysregulation of glucose transport and transporters in perfused hearts of genetically obese (fa/fa) rats
Zaninetti, D., Greco-Perotto, R., Assimacopoulos‐Jeannet, F., & Jeanrenaud, B. (1989) · Diabetologia · doi:10.1007/bf00265405 · Cited by 24
Endocrine, metabolic and cardioprotective effects of hexarelin in obese Zucker rats
Gennaro-Colonna, V. D., Rossoni, G., Cocchi, D., Rigamonti, A. E., Berti, F., & Ee, M. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660529 · Cited by 22
Isolated Hearts from Obese Rats Show Impaired Function during Hypoxia
Segel, L. D., Rendig, S. V., Mason, D. T., & Stern, J. S. (1980) · Experimental Biology and Medicine · doi:10.3181/00379727-163-40731 · Cited by 14
Rosiglitazone prevents ischaemic injury in the obese Zucker rat heart
Sidell, R. J., Cole, M. A., Draper, N., Clarke, K., & Buckingham, R. E. (2001) · Diabetologia · Cited by 3
Self-citation

Sorted by citations

Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228
Diabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543
Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes
Kolwicz, S. C., Purohit, S., & Tian, R. (2013) · Circulation Research · doi:10.1161/circresaha.113.302095 · Cited by 838
Cardiac remodeling in obesity
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Diabetic Cardiomyopathy
Poornima, I. G., Parikh, P., & Shannon, R. P. (2006) · Circulation Research · doi:10.1161/01.res.0000207406.94146.c2 · Cited by 567

See all 165

Authors: Sidell, R. J., Cole, M. A., Draper, N. J., Desrois, M., Buckingham, R. E., & Clarke, K.
Affiliations: University of Oxford (GB)
GlaxoSmithKline (United Kingdom) (GB)
ORCID: Cole, Mark A.
Desrois, Martine
Clarke, Kieran
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2002-04-01
Volume: 51
Issue: 4
Pages: 1110-1117
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.51.4.1110
OpenAlex: W2166216264
Cited by: 165
References: 50
Citations by year: 2026: 1 · 2025: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 8
FWCI: 8.50
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: British Heart Foundation (PS/02/002/14893)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: rosiglitazone, thiazolidinediones, insulin resistance, obesity, Zucker fatty rats, myocardial ischemia, myocardial ischemia-reperfusion injury, GLUT4, glucose uptake, cardiac contractile function, cardiac hypertrophy, congestive heart failure
MeSH terms: Rosiglitazone, Animals, Blood Glucose, Blood Pressure, Body Weight, Heart, Heart Rate, Hypoglycemic Agents, Insulin Resistance, Obesity, Organ Size, Perfusion, Rats, Zucker, Reference Values, Thiazoles, Time Factors, Myocardial Reperfusion, Myocardial Ischemia, Thiazolidinediones, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks