The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells
Open accessAbstract
Resistin is a hormone secreted by adipocytes that acts on skeletal muscle myocytes, hepatocytes, and adipocytes themselves, reducing their sensitivity to insulin. In the present study, we investigated how the expression of resistin is affected by glucose and by mediators known to affect insulin sensitivity, including insulin, dexamethasone, tumor necrosis factor-α (TNF-α), epinephrine, and somatropin. We found that resistin expression in 3T3-L1 adipocytes was significantly upregulated by high glucose concentrations and was suppressed by insulin. Dexamethasone increased expression of both resistin mRNA and protein 2.5- to 3.5-fold in 3T3-L1 adipocytes and by ∼70% in white adipose tissue from mice. In contrast, treatment with troglitazone, a thiazolidinedione antihyperglycemic agent, or TNF-α suppressed resistin expression by ∼80%. Epinephrine and somatropin were both moderately inhibitory, reducing expression of both the transcript and the protein by 30–50% in 3T3-L1 adipocytes. Taken together, these data make it clear that resistin expression is regulated by a variety of hormones and that cytokines are related to glucose metabolism. Furthermore, they suggest that these factors affect insulin sensitivity and fat tissue mass in part by altering the expression and eventual secretion of resistin from adipose cells.
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Cited by
Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity
Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpéné, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1427 · Cited by 910
Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664
An overview on biological mechanisms of PPARs
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Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity
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Lee, J. H., Chan, J. L., Yiannakouris, N., Kontogianni, M., Estrada, E., Seip, R., Orlova, C., & Mantzoros, C. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030519 · Cited by 548
Metadata
- Authors
- Shojima, N., Sakoda, H., Ogihara, T., Fujishiro, M., Katagiri, H., Anai, M., Onishi, Y., Ono, H., Inukai, K., Abe, M., Fukushima, Y., Kikuchi, M., Oka, Y., & Asano, T.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-06-01
- Volume
- 51
- Issue
- 6
- Pages
- 1737-1744
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2114671731
- Cited by
- 207
- References
- 9
- FWCI
- 19.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shojima, N., Sakoda, H., Ogihara, T., Fujishiro, M., Katagiri, H., Anai, M., Onishi, Y., Ono, H., Inukai, K., Abe, M., Fukushima, Y., Kikuchi, M., Oka, Y., & Asano, T. (2002). Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells. Diabetes. https://doi.org/10.2337/diabetes.51.6.1737
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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