The role of TNFα and TNF receptors in obesity and insulin resistance

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728 · see citing works

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,206 · see citing works

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

Hotamışlıgil, G. S., Johnson, R. S., Distel, R. J., Ellis, R., Papaioannou, V. E., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5291.1377 · Cited by 917 · see citing works

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819 · see citing works

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

Saghizadeh, M., Ong, J. M., Garvey, W. T., Henry, R. R., & Kern, P. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118504 · Cited by 717 · see citing works

Modulation of Insulin Activities by Leptin

Cohen, B., Novick, D., & Rubinstein, M. (1996) · Science · doi:10.1126/science.274.5290.1185 · Cited by 716 · see citing works

A Molecular Basis for Insulin Resistance

Paz, K., Hemi, R., LeRoith, D., Karasik, A., Elhanany, E., Kanety, H., & Zick, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29911 · Cited by 553 · see citing works

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

Feinstein, R., Kanety, H., Papa, M. Z., Lunenfeld, B., & Karasik, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74276-8 · Cited by 550 · see citing works

Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

Ofei, F., Hurel, S. J., Newkirk, J., Sopwith, M., & Taylor, R. (1996) · Diabetes · doi:10.2337/diab.45.7.881 · Cited by 510 · see citing works

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

Katz, E. B., Stenbit, A. E., Hatton, K. S., DePinho, R. A., & Charron, M. J. (1995) · Nature · doi:10.1038/377151a0 · Cited by 467 · see citing works

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

Kanety, H., Feinstein, R., Papa, M. Z., Hemi, R., & Karasik, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23780 · Cited by 435 · see citing works

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

Peraldi, P., Hotamisligil, G. S., Buurman, W. A., White, M. F., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13018 · Cited by 412 · see citing works

Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.

Kirchgessner, T. G., Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamışlıgil, G. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119824 · Cited by 412 · see citing works

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance

Hofmann, C. A., Lorenz, K., Braithwaite, S. S., Colca, J. R., Palazuk, B. J., Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Endocrinology · doi:10.1210/endo.134.1.8275942 · Cited by 387 · see citing works

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

Saad, M. J. A., Araki, E., Miralpeix, M., Rothenberg, P., White, M. F., & Kahn, C. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116060 · Cited by 323 · see citing works

Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

Maddux, B. A., Sbraccia, P., Kumakura, S., Sasson, S., YOUNGREN, J. F., Fisher, A., Spencer, S. A., Grupe, A., Henzel, W. J., Stewart, T. A., et al. (1995) · Nature · doi:10.1038/373448a0 · Cited by 308 · see citing works

Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans

Reynet, C., & Kahn, C. R. (1993) · Science · doi:10.1126/science.8248782 · Cited by 300 · see citing works

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

Ventre, J. R., Doebber, T. W., Wu, M. S., MacNaul, K. L., Stevens, K. A., Pasparakis, M., Kollias, G. A., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diab.46.9.1526 · Cited by 275 · see citing works

Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF-α-Mediated Insulin Resistance in Genetic Obesity**This work is supported in part by a grant from the NIH (DK-52539).

Uysal, K. T., Wiesbrock, S. M., & Hotamışlıgil, G. S. (1998) · Endocrinology · doi:10.1210/endo.139.12.6337 · Cited by 247 · see citing works

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.

Freidenberg, G. R., Henry, R. R., Klein, H. H., Reichart, D. R., & Olefsky, J. M. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112789 · Cited by 234 · see citing works

Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.

Kroder, G., Bossenmaier, B., Kellerer, M., Capp, E., Stoyanov, B., Mühlhöfer, A., Berti, L., Horikoshi, H., Ullrich, A., & Häring, H.-U. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118569 · Cited by 222 · see citing works

Relation Between Plasma Tumor Necrosis Factor-α and Insulin Sensitivity in Elderly Men With Non–Insulin-Dependent Diabetes Mellitus

Nilsson, J. Å., Jovinge, S. V., Niemann, A., Reneland, R., & Lithell, H. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.8.1199 · Cited by 200 · see citing works

Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor.

Liu, L. S., Spelleken, M., Röhrig, K., Hauner, H., & Eckel, J. (1998) · Diabetes · doi:10.2337/diabetes.47.4.515 · Cited by 178 · see citing works

Tumor Necrosis Factor-  in Sera of Obese Patients: Fall with Weight Loss

Dandona, P. (1998) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.8.2907 · Cited by 176 · see citing works

An in Vivo Model for Elucidation of the Mechanism of Tumor Necrosis Factor-α (TNF-α)-Induced Insulin Resistance: Evidence for Differential Regulation of Insulin Signaling by TNF-α

Cheung, A., Ree, D., Kolls, J. K., Fuselier, J. A., Coy, D. H., & Bryer‐Ash, M. (1998) · Endocrinology · doi:10.1210/endo.139.12.6336 · Cited by 153 · see citing works

Protein kinase C isoforms α, δ and θ require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

Kellerer, M., Mushack, J., Seffer, E., Mischak, H., Ullrich, A., & Häring, H. (1998) · Diabetologia · doi:10.1007/s001250050995 · Cited by 103 · see citing works

Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat

Hamann, A., Benecke, H., Marchand-Brustel, Y. L., Susulic, V. S., Lowell, B. B., & Flier, J. S. (1995) · Diabetes · doi:10.2337/diab.44.11.1266 · Cited by 89 · see citing works

Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF- -Mediated Insulin Resistance in Genetic Obesity

Uysal, K. T. (1998) · Endocrinology · doi:10.1210/en.139.12.4832 · Cited by 74 · see citing works

Tumor Necrosis Factor-α Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes1

Valverde, Á. M., Teruel, T., Navarro, P., Benito, M., & Lorenzo, M. (1998) · Endocrinology · doi:10.1210/endo.139.3.5854 · Cited by 65 · see citing works

Elevated serum tumour necrosis factor-alpha levels can contribute to the insulin resistance in Type II (non-insulin-dependent) diabetes and in obesity

Available, N. A. N. (1998) · Diabetologia · doi:10.1007/s001250051000 · Cited by 61 · see citing works

Increased interleukin-12 plasma concentrations in both, insulin-dependent and non-insulin-dependent diabetes mellitus

Winkler, G., Dworak, O., Salamon, F., Salamon, D., Speer, G., & Cseh, K. (1998) · Diabetologia · doi:10.1007/s001250050935 · Cited by 46 · see citing works

Protein kinase C (PKC) ϵ enhances the inhibitory effect of TNFα on insulin signaling in HEK293 cells

Kellerer, M., Mushack, J., Mischak, H., & Häring, H. U. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01357-4 · Cited by 36 · see citing works

An in Vivo Model for Elucidation of the Mechanism of Tumor Necrosis Factor- (TNF- )-Induced Insulin Resistance: Evidence for Differential Regulation of Insulin Signaling by TNF-

Cheung, A. T. (1998) · Endocrinology · doi:10.1210/en.139.12.4928 · Cited by 31 · see citing works

Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat

Hamann, A., Benecke, H., MARCHAND‐BRUSTEL, Y. L., et al. (1995) · Diabetes · doi:10.2337/diabetes.44.11.1266 · Cited by 27 · see citing works

Insulin resistance in man

Ratzmann, K. P. (1986) · Diabetologia · doi:10.1007/bf00456126 · Cited by 21 · see citing works

Tumor Necrosis Factor- Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes

Valverde, Á. M. (1998) · Endocrinology · doi:10.1210/en.139.3.1229 · Cited by 13 · see citing works

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,283 · see citing works

Adiponectin and Adiponectin Receptors

Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634 · see citing works

Adipocytes as regulators of energy balance and glucose homeostasis

Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · see citing works

The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487 · see citing works

Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women

Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., JOSHIPURA, K. J., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,174 · see citing works

Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin

Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M., & Scherer, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207198200 · Cited by 1,090 · see citing works

Pro-inflammatory cytokines and adipose tissue

Coppack, S. W. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns2001110 · Cited by 1,008 · see citing works

Adiponectin: More Than Just Another Fat Cell Hormone?

Chandran, M., Phillips, S. A., Ciaraldi, T. P., & Henry, R. R. (2003) · Diabetes Care · doi:10.2337/diacare.26.8.2442 · Cited by 1,007 · see citing works

Mitochondrial Dynamics in Mammalian Health and Disease

Liesa, M., Palacín, M., & Zorzano, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00030.2008 · Cited by 953 · see citing works

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912 · see citing works

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911 · see citing works

Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis

Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works

Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles

FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875 · see citing works

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 919 · see citing works

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway

Feldstein, A. E., Werneburg, N. W., Canbay, A. E., Guicciardi, M. E., Bronk, S. F., Rydzewski, R. M., Burgart, L. J., & Gores, G. J. (2004) · Hepatology · doi:10.1002/hep.20283 · Cited by 834 · see citing works

Diabetes Mellitus and Inflammation

Lontchi‐Yimagou, E., Sobngwi, E., Matsha, T. E., & Kengne, A. P. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0375-y · Cited by 814 · see citing works

Is obesity an inflammatory condition?

Das, U. N. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00672-4 · Cited by 799 · see citing works

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777 · see citing works

Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance

Shintani, Y., Fujie, H., Miyoshi, H., Tsutsumi, T., Tsukamoto, K., Kimura, S., Moriya, K., & Koike, K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.056 · Cited by 761 · see citing works

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works

The link between abdominal obesity, metabolic syndrome and cardiovascular disease

Ritchie, S. A., & Connell, J. M. C. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.07.005 · Cited by 726 · see citing works

The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

Yu, J. G., Javorschi, S., Hevener, A. L., Kruszynska, Y. T., Norman, R. A., Sinha, M. K., & Olefsky, J. M. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2968 · Cited by 724 · see citing works

Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression

Hui, J. M., Sud, A., Farrell, G. C., Bandara, P., Byth, K., Kench, J. G., McCaughan, G. W., & George, J. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.032 · Cited by 717 · see citing works

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

Saltiel, A. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00239-2 · Cited by 684 · see citing works

Adiponectin: action, regulation and association to insulin sensitivity

Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00159.x · Cited by 660 · see citing works

Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes

Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., & Paschke, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6307 · Cited by 655 · see citing works

Role of leptin and adiponectin in insulin resistance

Yadav, A., Kataria, M. A., Saini, V., & Yadav, A. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.12.007 · Cited by 636 · see citing works

The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

Yamauchi, T., Kamon, J., Waki, H., Murakami, K., Motojima, K., Komeda, K., Ide, T., Kubota, N., Terauchi, Y., Tobe, K., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103241200 · Cited by 635 · see citing works

Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression

Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works

Adipose Tissue-Derived Factors: Impact on Health and Disease

Trujillo, M. E., & Scherer, P. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0033 · Cited by 611 · see citing works

Age-related inflammatory cytokines and disease

Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608 · see citing works

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

Marı́, M., Caballero, F. G., Colell, A., Morales, A., Caballería, J., Fernandez, A., Enrich, C., Fernández-Checa, J. C., & García‐Ruiz, C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.006 · Cited by 605 · see citing works

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

Rui, L., Aguirre, V., Kim, J. K., Shulman, G. I., Lee, A., Corbould, A. M., Dunaif, A. E., & White, M. F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10934 · Cited by 600 · see citing works

Muscle‐derived interleukin‐6: possible biological effects

Pedersen, B. K., Steensberg, A., & Schjerling, P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0329c.xd · Cited by 599 · see citing works

Sarcopenic obesity and inflammation in the InCHIANTI study

Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00627.2006 · Cited by 594 · see citing works

Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin

Combs, T. P., Berg, A. H., Rajala, M. W., Klebanov, S., Iyengar, P., Jimenez-Chillaron, J. C., Patti, M. E., Klein, S. L., Weinstein, R. S., & Scherer, P. E. (2003) · Diabetes · doi:10.2337/diabetes.52.2.268 · Cited by 544 · see citing works

Decreased Plasma Adiponectin Concentrations in Women with Dyslipidemia

Matsubara, M., Maruoka, S., & Katayose, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8550 · Cited by 544 · see citing works

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works

Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes

Faßhauer, M., Kralisch, S., Klier, M., Lössner, U., Blüher, M., Klein, J. C., & Paschke, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00090-1 · Cited by 534 · see citing works

Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis

Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 522 · see citing works

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

Ertunc, M. E., & Hotamışlıgil, G. S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066514 · Cited by 485 · see citing works

Adiponectin, TNF-α and Inflammatory Cytokines and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis

Liu, C., Feng, X., Li, Q., Wang, Y., Li, Q., & Hua, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.028 · Cited by 470 · see citing works

The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance

Rinella, M. E., & Green, R. M. (2003) · Journal of Hepatology · doi:10.1016/j.jhep.2003.09.020 · Cited by 462 · see citing works

The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss

Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461 · see citing works

Exacerbations of chronic obstructive pulmonary disease

Celli, B. R., & Barnes, P. J. (2007) · European Respiratory Journal · doi:10.1183/09031936.00109906 · Cited by 460 · see citing works

Matrix Metalloproteinases Are Differentially Expressed in Adipose Tissue during Obesity and Modulate Adipocyte Differentiation

Carine Chavey, A., Mari, B. P., Monthouel, M.-N., Bonnafous, S., Anglard, P., OBBERGHEN, E. V., & Tartare‐Deckert, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209196200 · Cited by 447 · see citing works

The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations

Cnop, M., Landchild, M. J., Vidal, J., Havel, P. J., Knowles, N. G., Carr, D. R., Wang, F., Hull, R. L., Boyko, E. J., Retzlaff, B. M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1005 · Cited by 432 · see citing works

Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer

Feliciano, E. M. C., Kroenke, C. H., Meyerhardt, J. A., Prado, C. M. M., Bradshaw, P. T., Kwan, M. L., Xiao, J., Alexeeff, S., Corley, D. A., Weltzien, E. K., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.2319 · Cited by 428 · see citing works

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

Cipriani, S., Mencarelli, A., Palladino, G., & Fiorucci, S. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001602 · Cited by 410 · see citing works

Endothelial Dysfunction in Obesity and Insulin Resistance: A Road to Diabetes and Heart Disease

Caballero, A. E. (2003) · Obesity Research · doi:10.1038/oby.2003.174 · Cited by 416 · see citing works

Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists

Way, J. M., Görgün, C. Z., Tong, Q., Uysal, K. T., Brown, K. K., Harrington, W. W., Oliver, W. R., Willson, T. M., Kliewer, S. A., & Hotamışlıgil, G. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100189200 · Cited by 414 · see citing works

Obesity, Inflammation, and Periodontal Disease

Pischon, N., Heng, N., Bernimoulin, J. ‐., Kleber, B. M., Willich, S. N., & Pischon, T. (2007) · Journal of Dental Research · doi:10.1177/154405910708600503 · Cited by 403 · see citing works

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

Petersen, K. F., & Shulman, G. I. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02554-7 · Cited by 390 · see citing works

PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences

Alessi, M.-C., & Juhan-Vague, I. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000242905.41404.68 · Cited by 390 · see citing works

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

Deng, T., Lyon, C. J., Minze, L. J., Lin, J., Zou, J., Liu, J. Z., Ren, Y., Yin, Z., Hamilton, D. J., Reardon, P. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.009 · Cited by 382 · see citing works

Expression of <i>Mfn2</i>, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle

Bach, D., Naon, D., Pich, S., Soriano, F. X., Vega, N., Rieusset, J., Laville, M., Guillet, C., Boirie, Y., Wallberg-Henriksson, H., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2685 · Cited by 369 · see citing works

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

Caballero, F., Fernández, A., De Lacy, A. M., Fernández-Checa, J. C., Caballería, J., & García-Ruiz, C. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.016 · Cited by 368 · see citing works

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

Zhao, W., & Townsend, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 353 · see citing works

Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes

Pedersen, M., Bruunsgaard, H., Weis, N., Hendel, H. W., Andreassen, B. U., Eldrup, E., Dela, F., & Pedersen, B. K. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00027-7 · Cited by 342 · see citing works

Inflammatory Markers, Adiponectin, and Risk of Type 2 Diabetes in the Pima Indian

Krakoff, J. A., Funahashi, T., Stehouwer, C. D. A., Schalkwijk, C. G., Tanaka, S., Matsuzawa, Y., Kobes, S., Tataranni, P. A., Hanson, R. L., Knowler, W. C., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1745 · Cited by 334 · see citing works

Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance

Havel, P. J. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000410 · Cited by 329 · see citing works

Metabolic effects of obesity: A review

Singla, P. (2010) · World Journal of Diabetes · doi:10.4239/wjd.v1.i3.76 · Cited by 330 · see citing works

Obesity: epidemiology and clinical aspects

Formiguera, X., & Cantón, A. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2004.06.030 · Cited by 326 · see citing works

Elevated levels of tumor necrosis factor alpha and mortality in centenarians

Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J. V. B., Pedersen, B. K., & Jeune, B. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00329-2 · Cited by 325 · see citing works

Intramuscular Heat Shock Protein 72 and Heme Oxygenase-1 mRNA Are Reduced in Patients With Type 2 Diabetes

Bruce, C. R., Carey, A. L., Hawley, J. A., & Febbraio, M. A. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2338 · Cited by 318 · see citing works

Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

Yamauchi, T., Waki, H., Kamon, J., Murakami, K., Motojima, K., Komeda, K., Miki, H., Kubota, N., Terauchi, Y., Tsuchida, A., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12864 · Cited by 304 · see citing works

Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse1,2

Vick, M. M., Adams, A. A., Murphy, B. A., Sessions, D. R., Horohov, D. W., Cook, R. F., Shelton, B. J., & Fitzgerald, B. P. (2007) · Journal of Animal Science · doi:10.2527/jas.2006-673 · Cited by 307 · see citing works

Pathophysiological implications of insulin resistance on vascular endothelial function

Wheatcroft, S. B., Williams, I. L., Shah, A. M., & Kearney, M. T. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.00869.x · Cited by 307 · see citing works

Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people

BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., & PEDERSEN, B. K. (2003) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.2003.02137.x · Cited by 300 · see citing works

Obesity in Dogs and Cats: A Metabolic and Endocrine Disorder

Zoran, D. L. (2010) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2009.10.009 · Cited by 297 · see citing works

Insulin-Lowering Agents in the Management of Polycystic Ovary Syndrome

Leo, V. D., Marca, A. L., & Petraglia, F. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0015 · Cited by 288 · see citing works

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

Law, I. K. M., Xu, A., Lam, K. S. L., Berger, T., Mak, T. W., Vanhoutte, P. M., Liu, J. T. C., Sweeney, G., Zhou, M., Yang, B., et al. (2010) · Diabetes · doi:10.2337/db09-1541 · Cited by 285 · see citing works

Body composition and its association with cardiometabolic risk factors in the elderly: A focus on sarcopenic obesity

Chung, J.-Y., Kang, H.-T., Lee, D.-C., Lee, H.-R., & Lee, Y.-J. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.09.007 · Cited by 283 · see citing works

Scorpion Venom and the Inflammatory Response

Petricevich, V. L. (2010) · Mediators of Inflammation · doi:10.1155/2010/903295 · Cited by 279 · see citing works

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis

Harwood, H. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.010 · Cited by 273 · see citing works

Chronic Obstructive Pulmonary Disease, Asthma, and Risk of Type 2 Diabetes in Women

Rana, J. S., Mittleman, M. A., Sheikh, J. K., Hu, F. B., Manson, J. E., Colditz, G. A., Speizer, F. E., Barr, R. G., & Camargo, C. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2478 · Cited by 267 · see citing works

Adiponectin gene expression is inhibited by β‐adrenergic stimulation via protein kinase A in 3T3‐L1 adipocytes

Faßhauer, M., Klein, J. C., Neumann, S., Eszlinger, M., & Paschke, R. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02960-x · Cited by 263 · see citing works

Exercise and type 2 diabetes: focus on metabolism and inflammation

Karstoft, K., & Pedersen, B. K. (2016) · Immunology &amp; Cell Biology · doi:10.1038/icb.2015.101 · Cited by 260 · see citing works

The role of intramuscular lipid in insulin resistance

Hegarty, B. D., Furler, S. M., Ye, J.-M., Cooney, G. J., & Kraegen, E. W. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01162.x · Cited by 256 · see citing works

Adiponectin Inhibits Endothelial Synthesis of Interleukin-8

Kobashi, C., Urakaze, M., Kishida, M., Kibayashi, E., Kobayashi, H., Kihara, S., Funahashi, T., Takata, M., Temaru, R., Sato, A., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000194328.57164.36 · Cited by 255 · see citing works

Hyperglycemia-induced Production of Acute Phase Reactants in Adipose Tissue

Lin, Y., Rajala, M. W., Berger, J. P., Moller, D. E., Barzilai, N., & Scherer, P. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107101200 · Cited by 255 · see citing works

Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus

Miyazaki, Y., Glass, L. C., Triplitt, C. L., Wajcberg, E., Mandarino, L. J., & DeFronzo, R. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.0327.2001 · Cited by 251 · see citing works

Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain

Engström, G., Hedblad, B., Stavenow, L., Lind, P., Janzon, L., & Lindgärde, F. (2003) · Diabetes · doi:10.2337/diabetes.52.8.2097 · Cited by 249 · see citing works

Adipocyte-Derived Hormones, Cytokines, and Mediators

Rondinone, C. M. (2006) · Endocrine · doi:10.1385/endo:29:1:81 · Cited by 246 · see citing works

Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers

Pischon, T., Hankinson, S. E., Hotamisligil, G. S., Rifai, N., & Rimm, E. B. (2003) · Obesity Research · doi:10.1038/oby.2003.145 · Cited by 245 · see citing works

High-fat emulsion-induced rat model of nonalcoholic steatohepatitis

Zou, Y., Li, J., Lü, C., Wang, J., Ge, J., Huang, Y., Zhang, L., & Wang, Y. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.021 · Cited by 239 · see citing works

Hepatitis C virus infection: Molecular pathways to metabolic syndrome

Sheikh, M. Y., Choi, J., Qadri, I., Friedman, J. E., & Sanyal, A. J. (2008) · Hepatology · doi:10.1002/hep.22269 · Cited by 239 · see citing works

Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?

Das, U. N. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0226 · Cited by 238 · see citing works

Complement C3 Is a Risk Factor for the Development of Diabetes

Engström, G., Hedblad, B., Eriksson, K., Janzon, L., & Lindgärde, F. (2005) · Diabetes · doi:10.2337/diabetes.54.2.570 · Cited by 231 · see citing works

Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects

Pedersen, B. K., Steensberg, A., Keller, P., Keller, C., Fischer, C., Hiscock, N., van Hall, G., Plomgaard, P., & Febbraio, M. A. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0981-z · Cited by 228 · see citing works

Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-α

Pérez‐Matute, P., Pérez-Echarri, N., Martínez, J. A., Martí, A., & Moreno-Aliaga, M. J. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507207627 · Cited by 227 · see citing works

Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Activity and Messenger Ribonucleic Acid Levels Are Associated with Adiposity and Insulinemia in Pima Indians and Caucasians

Lindsay, R. S., Wake, D. J., Nair, S., Bunt, J., Livingstone, D. E. W., Permana, P. A., Tataranni, P. A., & Walker, B. R. (2003) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2002-030017 · Cited by 225 · see citing works

Association between the stress hyperglycemia ratio and 28-day all-cause mortality in critically ill patients with sepsis: a retrospective cohort study and predictive model establishment based on machine learning

Yan, F., Chen, X., Quan, X., Wang, L., Wei, X., & Zhu, J. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02265-4 · Cited by 224 · see citing works

Cytokines and β-Cell Biology: from Concept to Clinical Translation

Donath, M. Y., Størling, J., Berchtold, L. A., Billestrup, N., & Mandrup-Poulsen, T. R. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0033 · Cited by 219 · see citing works

Defective Insulin-Induced GLUT4 Translocation in Skeletal Muscle of High Fat–Fed Rats Is Associated With Alterations in Both Akt/Protein Kinase B and Atypical Protein Kinase C (ζ/λ) Activities

Tremblay, F., Lavigne, C., Jacques, H., & Marette, A. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1901 · Cited by 214 · see citing works

C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women

Pannacciulli, N., Cantatore, F. P., Minenna, A., Bellacicco, M., GIORGINO, R., & Pergola, G. D. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801719 · Cited by 209 · see citing works

Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells

Shojima, N., Sakoda, H., Ogihara, T., Fujishiro, M., Katagiri, H., Anai, M., Onishi, Y., Ono, H., Inukai, K., Abe, M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1737 · Cited by 207 · see citing works

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819 · see citing works

Impairment of the IR-IRS-PI3K-AKT signaling pathway in Insulin Resistance: New Insights into Insulin Resistance MechanismsPreprint

Ahmad, S. A. (2025) · doi:10.22541/au.175767205.55981786/v1 · Cited by 2 · see citing works

Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction

Stephens, J. M., Lee, J., & Pilch, P. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.971 · Cited by 553 · see citing works

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works

Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12

Lorenzo, M., Fernández‐Veledo, S., Vila‐Bedmar, R., García‐Guerra, L., de Álvaro, C., & Nieto-Vázquez, I. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0462 · Cited by 156 · see citing works