The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy
Open accessAbstract
We evaluated the effects of chronic hyperglycemia on L5 dorsal root ganglion (DRG) neurons using immunohistochemical and electrophysiologic techniques for evidence of oxidative injury. Experimental diabetic neuropathy was induced by streptozotocin. To evaluate the pathogenesis of the neuropathy, we studied peripheral nerve after 1, 3, and 12 months of diabetes. Electrophysiologic abnormalities were present from the first month and persisted over 12 months. 8-Hydroxy-2′-deoxyguanosine labeling was significantly increased at all time points in DRG neurons, indicating oxidative injury. Caspase-3 labeling was significantly increased at all three time points, indicating commitment to the efferent limb of the apoptotic pathway. Apoptosis was confirmed by a significant increase in the percentage of neurons undergoing apoptosis at 1 month (8%), 3 months (7%), and 12 months (11%). These findings support the concept that oxidative stress leads to oxidative injury of DRG neurons, with mitochondrium as a specific target, leading to impaired mitochondrial function and apoptosis, manifested clinically as a predominantly sensory neuropathy.
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Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779
Oxidative damage and mitochondrial decay in aging.
Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,725
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
Turrens, J. F., & Boveris, A. (1980) · Biochemical Journal · doi:10.1042/bj1910421 · Cited by 1,601
Seligman, A. M., Karnovsky, M. J., Wasserkrug, H. L., & Hanker, J. S. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.38.1.1 · Cited by 883
Oxygen radicals and the nervous system
Halliwell, B., & Gutteridge, J. M. C. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90010-4 · Cited by 819
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
Garcia Soriano, F., Virág, L., Jagtap, P., Szabó, É., Mabley, J. G., Liaudet, L., Marton, A., Hoyt, D. G., Murthy, K. G. K., Salzman, A. L., et al. (2001) · Nature Medicine · doi:10.1038/83241 · Cited by 603
(1997) · PubMed · Cited by 581
Reactive oxygen species‐induced molecular damage and its application in pathology
Toyokuni, S. (1999) · Pathology International · doi:10.1046/j.1440-1827.1999.00829.x · Cited by 552
Contributions of polyol pathway to oxidative stress in diabetic cataract
LEE, A. Y. W., & CHUNG, S. S. M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.23 · Cited by 533
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Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?
Akter, K., Lanza, E. A., Martin, S. A., Myronyuk, N., Rua, M., & Raffa, R. B. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03830.x · Cited by 352
Diabetes-Induced Mitochondrial Dysfunction in the Retina
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Vincent, A. M., Edwards, J. L., McLean, L. L., Hong, Y., Cerri, F., Lopez, I., Quattrini, A., & Feldman, E. L. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0697-7 · Cited by 152
The blood brain barrier in Alzheimer’s disease
Chakraborty, A., de Wit, N. M., van der Flier, W. M., & de Vries, H. E. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2016.11.008 · Cited by 118
Shah, S., Iqbal, M., Karam, J., Salifu, M., & McFarlane, S. I. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1629 · Cited by 115
Metadata
- Authors
- Schmeichel, A. M., Schmelzer, J. D., & Low, P. A.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-01-01
- Volume
- 52
- Issue
- 1
- Pages
- 165-171
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2160836484
- Cited by
- 367
- References
- 40
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schmeichel, A. M., Schmelzer, J. D., & Low, P. A. (2003). Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy. Diabetes. https://doi.org/10.2337/diabetes.52.1.165
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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