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The biochemistry of apoptosis

Hengartner, Michael O.·2000·Nature
DOI 10.1038/35037710
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Abstract

Apoptosis--the regulated destruction of a cell--is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

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Metadata

Authors
Hengartner, M. O.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2000-10
Volume
407
Issue
6805
Pages
770-776
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/35037710
Cited by
5,779
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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