The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effect of Type 1 Diabetes on the Gender Difference in Coronary Artery Calcification: a Role for Insulin Resistance?
Open accessAbstract
The objective of this is study was to examine whether estimated insulin resistance and insulin resistance-related factors are associated with coronary artery calcification (CAC) in 1,420 asymptomatic participants in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. A total of 656 patients with type 1 diabetes and 764 control subjects aged 20–55 years were examined. CAC was assessed by electron-beam computed tomography. Insulin resistance was computed with linear regression based on an equation previously validated in clamp studies on type 1 diabetic adults. Insulin resistance was associated with CAC (OR 1.6 in type 1 diabetes and 1.4 in control subjects, P < 0.001), independent of coronary artery disease risk factors. There was a male excess of CAC in control subjects (OR 2.7, adjusted for age, smoking, and LDL and HDL cholesterol levels) and in type 1 diabetic patients (OR 2.2, adjusted for the same factors and diabetes duration). After adjusting for insulin resistance, the CAC male excess in diabetic patients decreased from OR 2.2 (P < 0.001) to 1.8 (P = 0.04). After adjustment for waist-to-hip ratio, waist circumference, or visceral fat, the gender difference in CAC was not significant in diabetic subjects. In conclusion, gender differences in insulin resistance-associated fat distribution may explain why type 1 diabetes increases coronary calcification in women relatively more than in men.
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Cites
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.
Després, J. P., Moorjani, S., Lupien, P. J., Tremblay, A., Nadeau, A., & Bouchard, C. (1990) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.10.4.497 · Cited by 1,248
Prediction of coronary events with electron beam computed tomography
Arad, Y., Spadaro, L. A., Goodman, K., Newstein, D., & Guerci, A. D. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00872-x · Cited by 744 · cited 1×
“Prospectively, coronary calcification predicts cardiovascular events, even in asymptomatic individuals (12,13).”
BackgroundCan clinical factors estimate insulin resistance in type 1 diabetes?
Williams, K. V., Erbey, J. R., Becker, D., Arslanian, S., & Orchard, T. J. (2000) · Diabetes · doi:10.2337/diabetes.49.4.626 · Cited by 640
Cited by
Katsarou, A., Gudbjörnsdottir, S., Rawshani, A., Dabelea, D., Bonifacio, E., Anderson, B. J., Jacobsen, L. M., Schatz, D. A., & Lernmark, Å. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.16 · Cited by 1,475
Self-citationJellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., Grunberger, G., Guerin, C. K., Bell, D. S. H., Mechanick, J. I., et al. (2017) · Endocrine Practice · doi:10.4158/ep171764.appgl · Cited by 1,094
Urbina, E. M., Williams, R. V., Alpert, B. S., Collins, R. T., Daniels, S. R., Hayman, L., Jacobson, M., Mahoney, L., Mietus-Snyder, M., Rocchini, A., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.192639 · Cited by 641
de Ferranti, S. D., de Boer, I. H., Fonseca, V., Fox, C. S., Golden, S. H., Lavie, C. J., Magge, S. N., Marx, N., McGuire, D. K., Orchard, T. J., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000034 · Cited by 503
Self-citationHuxley, R. R., Peters, S. A. E., Mishra, G. D., & Woodward, M. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70248-7 · Cited by 383
Metadata
- Authors
- Dabelea, D., Kinney, G., Snell-Bergeon, J. K., Hokanson, J. E., Eckel, R. H., Ehrlich, J., Garg, S., Hamman, R. F., & Rewers, M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-11-01
- Volume
- 52
- Issue
- 11
- Pages
- 2833-2839
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2152512217
- Cited by
- 250
- References
- 3
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Dabelea, D., Kinney, G., Snell-Bergeon, J. K., Hokanson, J. E., Eckel, R. H., Ehrlich, J., Garg, S., Hamman, R. F., & Rewers, M. (2003). Effect of Type 1 Diabetes on the Gender Difference in Coronary Artery Calcification: a Role for Insulin Resistance? Diabetes. https://doi.org/10.2337/diabetes.52.11.2833
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
