Cited by 373Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and ResearchDiabetes Treatment and Management

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Microvascular Complications of Impaired Glucose Tolerance

Open access

Singleton, J. Robinson, Smith, A. Gordon, Russell, James W., Feldman, Eva L.·2003·Diabetes

DOI 10.2337/diabetes.52.12.2867

Open this paper in CoChat — free account Open PDF

Abstract

Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts both large- and small-vessel vascular complications, independent of a patient’s progression to diabetes. Patients with IGT are at significantly increased risk for death and morbidity due to myocardial infarction, stroke, and large-vessel occlusive disease. IGT is more predictive of cardiovascular morbidity than impaired fasting glucose, probably because it is a better surrogate for the state of insulin resistance. IGT is also independently associated with traditional microvascular complications of diabetes, including retinopathy, renal disease, and polyneuropathy, which are the topics of this review. Inhibition of nitric oxide-mediated vasodilation, endothelial injury due to increased release of free fatty acids and adipocytokines from adipocytes, and direct metabolic injury of endothelial and end-organ cells contribute to vascular complications. Early detection of IGT allows intensive diet and exercise modification, which has proven significantly more effective than drug therapy in normalizing postprandial glucose and inhibiting progression to diabetes. To what degree intervention will limit recognized complications is not known.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/diabetes.52.12.2867

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,325
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703
Advanced glycation end-products: A review
Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597
Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress
Esposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., Quagliaro, L., Ceriello, A., & Giugliano, D. (2002) · Circulation · doi:10.1161/01.cir.0000034509.14906.ae · Cited by 1,961
Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes
Mogensen, C. E. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402093100605 · Cited by 1,898
Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
Sinha, R., Fisch, G., Teague, B., Tamborlane, W. V., Banyas, B., Allen, K., Savoye, M., Rieger, V., Taksali, S., Barbetta, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012578 · Cited by 1,709

Show all 50 references

Sorted by citations

Items 101–200 of 373

Endothelin-A Receptor Blockade Increases Nutritive Skin Capillary Circulation in Patients with Type 2 Diabetes and Microangiopathy
Settergren, M., Pernow, J., Brismar, K., Jörneskog, G., & Kalani, M. (2008) · Journal of Vascular Research · doi:10.1159/000113601 · Cited by 42
Prevalence and Psychosocial Correlates of Diabetes Mellitus in South Africa: Results from the South African National Health and Nutrition Examination Survey (SANHANES-1)
Sifunda, S., Mbewu, A. D., Mabaso, M., Manyaapelo, T., Sewpaul, R., Morgan, J. W., Harriman, N. W., Williams, D. R., & Reddy, P. S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20105798 · Cited by 42
Elevated Serum Levels of Advanced Glycation End Products and their Monocyte Receptors in Patients with Type 2 Diabetes
Su, X., Shou-she, L. I., Tian, Y., Zhang, Z.-Y., Zhang, G., & Wang, L. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.11.001 · Cited by 42
Influence of obesity and insulin resistance on left atrial size in children
Hirschler, V., Acebo, H. L. P., Fernandez, G. B., de Lujan Calcagno, M., Gonzalez, C., & Jadzinsky, M. (2006) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2006.00139.x · Cited by 41
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors and microvascular outcomes in patients with type 2 diabetes: systematic review and meta-analysis
Dorsey-Treviño, E. G., González-González, J. G., Alvarez-Villalobos, N., González-Nava, V., Contreras-Garza, B. M., Díaz González-Colmenero, A., Rodríguez-Tamez, G., Barrera-Flores, F. J., Farrell, A. M., Montori, V. M., et al. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01103-9 · Cited by 39
Differential inhibition by hyperglycaemia of shear stress‐ but not acetylcholine‐mediated dilatation in the iliac artery of the anaesthetized pig
Kelly-Laubscher, R. F., Ruane-O’Hora, T., Noble, M. I. M., Drake‐Holland, A. J., & Snow, H. M. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.106500 · Cited by 40
Preoperative hyperglycemia and complication risk following neurosurgical intervention: A study of 918 consecutive cases
Davis, M., Sullivan, S., Ziewacz, J. E., & El‐Sayed, A. M. (2012) · Surgical Neurology International · doi:10.4103/2152-7806.96071 · Cited by 39
Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients
Lee, K. O., Nam, J. S., Ahn, C. W., Hong, J., Kim, S. M., Sunwoo, I., Moon, J.-S., Na, S.-J., & Choi, Y. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0176-6 · Cited by 38
A microcirculação no diabetes: implicações nas complicações crônicas e tratamento da doença
Kraemer‐Aguiar, L. G., Villela, N. R., & Bouskela, E. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000200009 · Cited by 37
Maternal salt and fat intake causes hypertension and sustained endothelial dysfunction in fetal, weanling and adult male resistance vessels
Gray, C. L., Harrison, C. J., Segovia, S. A., Reynolds, C. M., & Vickers, M. H. (2015) · Scientific Reports · doi:10.1038/srep09753 · Cited by 37
Diabetes Complications and Depressive Symptoms: Prospective Results From the Montreal Diabetes Health and Well-Being Study
Deschênes, S. S., Burns, R. J., Pouwer, F., & Schmitz, N. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000447 · Cited by 37
Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells
Cheluvappa, R., Denning, G. M., Lau, G. W., Grimm, M., Hilmer, S. N., & Couteur, D. G. L. (2010) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2010.02.2263 · Cited by 36
Skin microvascular endothelial dysfunction is associated with type 2 diabetes independently of microalbuminuria and arterial stiffness
Jonasson, H., Bergstrand, S., Nyström, F. H., Länne, T., Östgren, C. J., Bjarnegård, N., Fredriksson, I., Larsson, M., & Tomas Strömberg, A. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117707706 · Cited by 36
Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris
Strand, E., Rebnord, E. W., Flygel, M. R., Lysne, V., Svingen, G. F. T., Tell, G. S., Løland, K. H., Berge, R. K., Svardal, A. M., Nygard, O. K., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02139 · Cited by 35
Standing balance and trunk position sense in impaired glucose tolerance (IGT)-related peripheral neuropathy
Goldberg, A., Russell, J. W., & Alexander, N. B. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.03.002 · Cited by 34
Self-citation
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities
Sacco, S., Foschi, M., Ornello, R., Santis, F. D., Pofi, R., & Romoli, M. (2024) · Diabetologia · doi:10.1007/s00125-024-06146-z · Cited by 41
Neuropathy and impaired glucose tolerance: an updated review of the evidence
Rajabally, Y. A. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01425.x · Cited by 34
Glycaemic variability and inflammation in subjects with metabolic syndrome
Buscemi, S., Verga, S., Cottone, S., Azzolina, V., Buscemi, B., Gioia, D., & Cerasola, G. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0061-8 · Cited by 34
Therapy Insight: neurological complications of prediabetes
Singleton, J. R., & Smith, A. G. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0172 · Cited by 34
Self-citation
Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases
Hu, J., Ye, M., & Zhou, Z. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1485-1 · Cited by 34
Effect of Treatment of Sprague Dawley Rats with AVE7688, Enalapril, or Candoxatril on Diet-Induced Obesity
Davidson, E. P., Coppey, L. J., Dake, B. L., & Yorek, M. A. (2010) · Journal of Obesity · doi:10.1155/2011/686952 · Cited by 33
Pathological Hyperinsulinemia and Hyperglycemia in the Impaired Glucose Tolerance Stage Mediate Endothelial Dysfunction Through miR-21, PTEN/AKT/eNOS, and MARK/ET-1 Pathways
Liu, R., Guan, S., Gao, Z., Wang, J., Xu, J., Hao, Z., Zhang, Y., Yang, S., Guo, Z., Yang, J., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.644159 · Cited by 33
Within-visit blood pressure variability is associated with prediabetes and diabetes
Okada, R., Yasuda, Y., Tsushita, K., Wakai, K., Hamajima, N., & Matsuo, S. (2015) · Scientific Reports · doi:10.1038/srep07964 · Cited by 33
Bimodality of 2-h Plasma Glucose Distributions in Whites
Fan, J., May, S. J., Zhou, Y., & Barrett-Connor, E. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1451 · Cited by 31
Insulin resistance increases risk of carpal tunnel syndrome: a case‐control study
Plastino, M., Fava, A., Colica, C., Bartolo, M. D., Ermio, C., Cristiano, D., Ettore, M., Abenavoli, L., & Bosco, D. (2011) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2011.00344.x · Cited by 31
Pathophysiology of the proatherothrombotic state in the metabolic syndrome
Navarro, H. G. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s57 · Cited by 32
A very low carbohydrate ketogenic diet prevents the progression of hepatic steatosis caused by hyperglycemia in a juvenile obese mouse model
OKUDA, T., & Morita, N. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.24 · Cited by 30
The Diabetic Neuropathies: Practical and Rational Therapy
Singleton, J., & Smith, A. G. (2012) · Seminars in Neurology · doi:10.1055/s-0032-1329195 · Cited by 31
Self-citation
Undiagnosed dysglycaemia and inflammation in cardiovascular disease
Johansen, O. E., Birkeland, K., Brustad, E., Aaser, E., Lindahl, A. K., Midha, R., Ueland, T., Aukrust, P., & Gullestad, L. L. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01679.x · Cited by 30
Epidemiology of diabetes mellitus and associated cardiovascular risk factors: Focus on human immunodeficiency virus and psychiatric disorders
Zimmet, P. (2005) · The American Journal of Medicine Supplements · doi:10.1016/j.amjmed.2005.01.044 · Cited by 30
Operative Debridement of Diabetic Foot Ulcers
Golinko, M. S., Joffe, R., Maggi, J. C., Cox, D., Chandrasekaran, E., Tomic‐Canic, M., & Brem, H. (2008) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2008.09.018 · Cited by 30
Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes
Jamieson, H. A., Cogger, V. C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., Hilmer, S. N., Fraser, R., de Cabo, R., & Couteur, D. G. L. (2007) · Diabetologia · doi:10.1007/s00125-007-0739-4 · Cited by 29
Early microvascular complications of prediabetes in mice with impaired glucose tolerance and dyslipidemia
Schaefer, C., Biermann, T., Schroeder, M., Fuhrhop, I., Niemeier, A., Rüther, W., Algenstaedt, P., & Hansen‐Algenstaedt, N. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0114-7 · Cited by 29
Metabolic effects of the incretin mimetic exenatide in the treatment of type 2 diabetes
Schnabel, C. A., Wintle, M. E., & Kolterman, O. (2006) · Vascular Health and Risk Management · doi:10.2147/vhrm.2006.2.1.69 · Cited by 29
Increased glycemic variability and decrease of the postprandial glucose contribution to HbA1c in obese subjects across the glycemic continuum from normal glycemia to first time diagnosed diabetes
Fysekidis, M., Cosson, E., Banu, I., Duteil, R., Cyrille, C., & Valensi, P. E. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.006 · Cited by 29
Alanine variant of the Pro12Ala polymorphism of the PPARγ gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes
Malecki, M. T., Cyganek, K., Mirkiewicz-Sieradzka, B., Wołkow, P. P., Wanic, K., SKUPIEN, J. K., Solnica, B., & Sieradzki, J. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.11.001 · Cited by 31
Is there a divergence in time trends in the prevalence of impaired glucose tolerance and diabetes? A systematic review in south Asian populations
Katikireddi, S. V., Morling, J. R., & Bhopal, R. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr159 · Cited by 28
The gene polymorphisms of UCP 1 but not PPAR γ and TCF 7L2 are associated with diabetic retinopathy in Chinese type 2 diabetes mellitus cases
Zhang, Y., Meng, N., Lv, Z., Li, H., & Qu, Y. (2014) · Acta Ophthalmologica · doi:10.1111/aos.12542 · Cited by 28
Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients
Anan, F., Takayuki, M., Takahashi, N., Nakagawa, M., Eshima, N., Saikawa, T., & Yoshimatsu, H. (2009) · Hypertension Research · doi:10.1038/hr.2009.8 · Cited by 27
American College of Endocrinology Pre-Diabetes Consensus Conference: Part Two
Bloomgarden, Z. T. (2008) · Diabetes Care · doi:10.2337/dc08-zb11 · Cited by 26
Arterial Stiffness and Cognition in Elderly Persons With Impaired Glucose Tolerance and Microalbuminuria
Abbatecola, A. M., Barbieri, M., Rizzo, M. R., Grella, R., Laieta, M. T., Quaranta, E., Molinari, A. M., Cioffi, M., Fioretto, P., & Paolisso, G. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.9.991 · Cited by 28
Relationship between fermented papaya preparation supplementation, erythrocyte integrity and antioxidant status in pre-diabetics
Somanah, J., Bourdon, E., Rondeau, P., Bahorun, T., & Aruoma, O. I. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.11.050 · Cited by 29
Monitoring Brain Oxygen Saturation During Coronary Bypass Surgery Improves Outcomes in Diabetic Patients: A Post Hoc Analysis
Murkin, J. M., Adams, S. J., Pardy, E., Quantz, M., McKenzie, F., & Guo, L.-R. R. (2011) · The Heart Surgery Forum · doi:10.1532/hsf98.20101065 · Cited by 26
Vitamin D in the Spectrum of Prediabetes and Cardiovascular Autonomic Dysfunction
Dimova, R. B., Tankova, T. I., & Chakarova, N. Y. (2017) · Journal of Nutrition · doi:10.3945/jn.117.250209 · Cited by 27
Glucose Metabolism, Insulin Resistance, and Renal Pathology in Non-Diabetic Chronic Kidney Disease
Ikee, R., Hamasaki, Y., Oka, M., Maesato, K., Mano, T., Moriya, H., Ohtake, T., & Kobayashi, S. (2008) · Nephron Clinical Practice · doi:10.1159/000115329 · Cited by 27
Long-lasting effect of obesity on skeletal muscle transcriptome
Messaoudi, I., Handu, M., Rais, M., Sureshchandra, S., Park, B. S., Fei, S. S., Wright, H., White, A. E., Jain, R., Cameron, J. L., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-3799-y · Cited by 26
Elevated neurofilament light chain (NFL) mRNA levels in prediabetic peripheral neuropathy
Çelikbilek, A., Tanık, N., Sabah, S., Börekçi, E., Akyol, L., Ak, H., Adam, M., Süher, M., & Yılmaz, N. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3270-y · Cited by 25
Waist circumference leads to prolonged microvascular reactive hyperemia response in young overweight/obese women
Kraemer‐Aguiar, L. G., Maranhao, P. A., Cyrino, F. Z. G. A., & Bouskela, E. (2010) · Microvascular Research · doi:10.1016/j.mvr.2010.08.004 · Cited by 25
Impaired Elastic Properties of the Aorta in Fat-Fed, Streptozotocin-Treated Rats
Sun, H. Q., Zhong, M., Miao, Y., Ma, X., Gong, H., Tan, H., Zhang, Y., & Zhang, W. (2009) · Cardiology · doi:10.1159/000219211 · Cited by 25
Lipid and inflammatory markers for the prediction of coronary artery disease: A multi-marker approach
Bogavac‐Stanojević, N., Jelić‐Ivanović, Z., Spasojević‐Kalimanovska, V., Spasić, S., & Kalimanovska‐Oštrić, D. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.05.012 · Cited by 25
Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through mitochondrial superoxide overproduction in adipocytes
Sun, J., Xu, Y., Deng, H., Sun, S., Dai, Z., & Sun, Y. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0088 · Cited by 25
The Initial Common Pathway of Inflammation, Disease, and Sudden Death
Davidson, R. M., & Seneff, S. (2012) · Entropy · doi:10.3390/e14081399 · Cited by 24
Cutaneous manifestations of diabetic peripheral neuropathy
Dogiparthi, S. N., Muralidhar, K., Seshadri, K. G., & Rangarajan, S. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1395537 · Cited by 27
30-days effects of vildagliptin on vascular function, plasma viscosity, inflammation, oxidative stress, and intestinal peptides on drug-naïve women with diabetes and obesity: a randomized head-to-head metformin-controlled study
Schiappacassa, A., Maranhao, P. A., de Souza, M. D. G. C., Panazzolo, D. G., Neto, J. F. N., Bouskela, E., & Kraemer‐Aguiar, L. G. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0466-2 · Cited by 27
Glucose metabolism in the idiopathic blepharoptosis: Utility of the Oral Glucose Tolerance Test (OGTT) and of the Insulin Resistance Index
Bosco, D., Costa, R., Plastino, M., Branca, D., Cotronei, P., Sperlì, T., Santacroce, N., Siniscalchi, A., Consoli, D., Ceccotti, C., et al. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.03.017 · Cited by 24
Association of the C-reactive protein–triglyceride–glucose index with metabolic dysfunction-associated steatotic liver disease and long-term all-cause and cardiovascular mortality: evidence from two nationwide prospective cohort studies
Jin, X., Su, Z., Zhong, J.-F., Wang, J., Shi, B., Liu, Z., Li, P.-S., Xiong, X., Xu, S., Qiu, C., et al. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03119-x · Cited by 28
Reactivity of the aorta and mesenteric resistance arteries from the obese spontaneously hypertensive rat: effects of glitazones
Mendizábal, Y., Llorens, S., & Nava, E. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01280.2010 · Cited by 23
Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose
Sun, L.-Q., Xue, B., Li, X.-J., Wang, X., Qu, L., Zhang, T., Zhao, J., Wang, B., Xiao-man, Z., Mu, Y., et al. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.10.001 · Cited by 23
Buccal spray insulin in subjects with impaired glucose tolerance: the prevoral study
Palermo, A., Napoli, N., Manfrini, S., Lauria, A., Strollo, R., & Pozzilli, P. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01312.x · Cited by 23
The effect of metabolic syndrome on Bell’s palsy recovery rate
Jung, S. Y., Jung, J., Byun, J. Y., Park, M. S., Kim, S. H., & Yeo, S. G. (2018) · Acta Oto-Laryngologica · doi:10.1080/00016489.2018.1425902 · Cited by 24
Exercising With Peripheral or Autonomic Neuropathy: What Health Care Providers and Diabetic Patients Need to Know
Colberg, S. R., & Vinik, A. I. (2014) · The Physician and Sportsmedicine · doi:10.3810/psm.2014.02.2043 · Cited by 23
Preparation and therapeutic evaluation of rutin-phospholipid complex for antidiabetic activity
Vankudri, R., Habbu, P., Hiremath, M., Patil, B. S., & Savant, C. B. (2016) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2016.600116 · Cited by 23
Impaired glucose tolerance: A possible contributor to left ventricular hypertrophy and diastolic dysfunction
Fujita, M., Asanuma, H., Kim, J., Liao, Y., Hirata, A., Tsukamoto, O., Minamino, T., Hori, M., Goto, M., Node, K., et al. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.07.004 · Cited by 22
Myocardial sympathetic innervation in patients with impaired glucose tolerance: relationship to subclinical inflammation
Diakakis, G., PARTHENAKIS, F. I., Patrianakos, A. P., Koukouraki, S., Stathaki, M. I., Karkavitsas, N. S., & Vardas, P. E. (2007) · Cardiovascular Pathology · doi:10.1016/j.carpath.2007.07.007 · Cited by 22
Current Concepts in Diabetic Microvascular Dysfunction
Fontaine, J. L., Harkless, L. B., Davis, C. E., Allen, M. A., & Shireman, P. K. (2006) · Journal of the American Podiatric Medical Association · doi:10.7547/0960245 · Cited by 22
Prevalence of undiagnosed diabetes and pre-diabetes among hypertensive patients attending Kiambu district Hospital, Kenya: a cross-sectional study
Meme, N., Amwayi, S. A., Nganga, Z., & Buregyeya, E. (2015) · Pan African Medical Journal · doi:10.11604/pamj.2015.22.286.7395 · Cited by 23
Morphological Restructuring of Myocardium During the Early Phase of Experimental Diabetes Mellitus
Danilova, I. G., Sarapultsev, P., Medvedeva, S. U., Гетте, И. Ф., Bulavintceva, T. S., & Sarapultsev, A. (2014) · The Anatomical Record · doi:10.1002/ar.23052 · Cited by 21
Is there cardiac autonomic neuropathy in prediabetes?
Zilliox, L. A., & Russell, J. W. (2020) · Autonomic Neuroscience · doi:10.1016/j.autneu.2020.102722 · Cited by 23
Self-citation
Attenuated Superoxide Dismutase Induction in Retinal Cells in Response to Intermittent High Versus Continuous High Glucose
Ihnat, M. A., Kaltreider, R. C., Thorpe, J. E., Green, D. E., Kamat, C. D., Leeper, M., Shanner, A. C., Warnke, L. A., Piconi, L., & Ceriello, A. (2007) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2007.16.23 · Cited by 21
Anti-diabetic effect of Semecarpus anacardium Linn nut milk extract in a high fat diet STZ-induced type 2 diabetic rat model
Khan, H. B. H., Vinayagam, K. S., Shanthi, P., & Sachdanandam, P. (2011) · Comparative Clinical Pathology · doi:10.1007/s00580-011-1305-5 · Cited by 20
The American College of Sports Medicine and the American Diabetes Association: joint position statement
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., Chasan‐Taber, L., Albright, A. L., & Braun, B. (2010) · Cited by 20
Use of RBC deformability index as an early marker of diabetic nephropathy
Lee, S. B., Kim, Y.-S., Kim, J. H., Park, K., Nam, J. S., Kang, S., Park, J. S., Shin, S., & Ahn, C. W. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-180434 · Cited by 20
Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway
Zhang, Y., Yang, S., Cui, X., Yang, J., Zheng, M., Jia, J., Han, F., Yang, X., Wang, J., Guo, Z., et al. (2019) · Journal of Diabetes Research · doi:10.1155/2019/4709715 · Cited by 22
Coadministration of Melatonin and Insulin Improves Diabetes-Induced Impairment of Rat Kidney Function
Hajam, Y. A., Rai, S., Pandi-Perumal, S. R., Brown, G. M., Reiter, R. J., & Cardinali, D. P. (2021) · Neuroendocrinology · doi:10.1159/000520280 · Cited by 20
Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy.
Tariq, K., Malik, S., Ali, S. H. B., Maqsood, S. E., Azam, A., Muslim, I., Khan, M. S., Azam, M., Waheed, N. K., & Qamar, R. (2013) · Europe PMC (PubMed Central) · Cited by 20
Metformin and its Effects on Myocardial Dimension and Left ventricular hypertrophy in Normotensive patients with Coronary Heart Disease (The MET ‐ REMODEL Study): Rationale and Design of the MET ‐ REMODEL Study
Mohan, M., McSwiggan, S., Baig, F., Rutherford, L., & Lang, C. C. (2014) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12101 · Cited by 20
CHARACTERISTICS OF ACID WHEY POWDER PARTIALLY DEMINERALISED BY NANOFILTRATION
Dec, B., & Chojnowski, W. (2006) · Conference Advance Technology · Cited by 20
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall
Romier, B., Dray, C., Vanalderwiert, L., Wahart, A., Hocine, T., Dortignac, A., Garbar, C., Garbar, C., Boulagnon‐Rombi, C., Bouland, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-01735-z · Cited by 19
Impact of Diabetes and Peripheral Arterial Occlusive Disease on the Functional Microcirculation at the Plantar Foot
Kabbani, M., Rotter, R., Busche, M. N., Würfel, W., Jokuszies, A., Knobloch, K., Vogt, P. M., & Kraemer, R. (2013) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0b013e3182a4b9cb · Cited by 19
Abnormal Retinal Vascular Reactivity in Individuals with Impaired Glucose Tolerance: A Preliminary Study
Patel, S. R., Bellary, S., Qin, L., Balanos, G. M., McIntyre, D. B., & Gherghel, D. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9512 · Cited by 19
Postprandial hyperglycemia alters inflammatory and hemostatic parameters
Wautier, J., Boulanger, É., & Wautier, M.-P. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(06)70483-9 · Cited by 19
Lipids, lipid-lowering therapy, and neuropathy: a narrative review
Pasha, R., Azmi, S., Ferdousi, M., Kalteniece, A., Bashir, B., Gouni-Berthold, I., Malik, R. A., & Soran, H. (2022) · Clinical Therapeutics · doi:10.1016/j.clinthera.2022.03.013 · Cited by 18
A New Approach to Glucose Control in Type 2 Diabetes: The Role of Kidney Sodium-Glucose Co-transporter 2 Inhibition
Basile, J. (2011) · Postgraduate Medicine · doi:10.3810/pgm.2011.07.2302 · Cited by 18
Recent clinical advances in diabetic polyneuropathy
Horowitz, S. H. (2006) · Current Opinion in Anaesthesiology · doi:10.1097/01.aco.0000245287.37905.c5 · Cited by 17
FISETIN, A BIOFLAVONOID AMELIORATES HYPERGLYCEMIA IN STZ-INDUCED EXPERIMENTAL DIABETES IN RATS
Prasath, G. S., & Subramanian, S. P. (2011) · Cited by 18
Hemorheologic Alterations in Patients with Type 2 Diabetes Mellitus Presented with an Acute Myocardial Infarction
Park, K.-H., Kim, U., Choi, K., Nam, J., Lee, J., Lee, C., Son, J., Park, J., Shin, D., Won, K. C., et al. (2018) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.42.2.155 · Cited by 18
The prevalence of diabetic retinopathy in Faisalabad, Pakistan: a population-based study
Hussain, F., ARIF, M., & Ahmad, M. (2011) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1002-589 · Cited by 18
Peripheral Neuropathy With Impaired Glucose Tolerance
Kissel, J. T. (2006) · Archives of Neurology · doi:10.1001/archneur.63.8.1055 · Cited by 18
American College of Endocrinology Pre-Diabetes Consensus Conference: Part One
Bloomgarden, Z. T. (2008) · Diabetes Care · doi:10.2337/dc08-zb10 · Cited by 17
Childhood Obesity and Insulin Resistance: How Should It Be Managed?
Ho, M. M., Garnett, S. P., & Baur, L. A. (2014) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-014-0351-0 · Cited by 18
Determination of nerve conduction abnormalities in patients with impaired glucose tolerance
Şahin, Ş., Karşıdağ, S., Ayalp, S., Şengül, A. M., Us, Ö., & Karşıdağ, K. (2009) · Neurological Sciences · doi:10.1007/s10072-009-0089-8 · Cited by 17
Hyperinsulinemia contributes to impaired-glucose-tolerance-induced renal injury via mir-7977/SIRT3 signaling
Gao, Z., Wang, Z., Zhu, H., Yuan, X., Sun, M., Wang, J., Zuo, M., Cui, X., Han, Y., Zhang, Y., et al. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320916008 · Cited by 17
Enhanced oral bioavailability and anti-diabetic activity of canagliflozin through a spray dried lipid based oral delivery: a novel paradigm
Singh, D., Singh, A. P., Singh, D., Kesavan, A. K., Arora, S., Tiwary, A. K., & Bedi, N. (2020) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-020-00330-3 · Cited by 16
Ceftezole, a cephem antibiotic, is an α-glucosidase inhibitor with in vivo anti-diabetic activity
Lee, D., Lee, J.-M., Kim, S., Chang, K.-T., & Lee, S. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.3.379 · Cited by 16
The Evaluation of Chronic Axonal Polyneuropathies
Mauermann, M. L., & Burns, T. M. (2008) · Seminars in Neurology · doi:10.1055/s-2008-1062270 · Cited by 17
Effect of Hepatic Lipase −514C→T Polymorphism and Its Interactions With Apolipoprotein C3 −482C→T and Apolipoprotein E Exon 4 Polymorphisms on the Risk of Nephropathy in Chinese Type 2 Diabetic Patients
Baum, L., Ng, M. C. Y., So, W., Lam, V. K. L., Wang, Y., Poon, E., Tomlinson, B., Cheng, S., Lindpaintner, K., & Chan, J. C. N. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1704 · Cited by 16
Exercise in the Prevention and Treatment of Type 2 Diabetes
Kirwan, J. P., Heintz, E. C., Rebello, C. J., & Axelrod, C. L. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220009 · Cited by 26
Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-β activity and TGF-β1 expression
Oriente, F., Iovino, S., Cassese, A., Romano, C., Miele, C., Troncone, G., Balletta, M., Perfetti, A., Santulli, G., Iaccarino, G., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1528-z · Cited by 15
The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes
Larsen, A. U., Grimnes, G., & Jorde, R. (2017) · Osteoporosis International · doi:10.1007/s00198-017-4222-x · Cited by 15
Evaluation of Nerve Conduction Studies in Obese Children With Insulin Resistance or Impaired Glucose Tolerance
İnce, H., Taşdemir, H. A., Aydın, M., Özyürek, H., & Tilki, H. E. (2014) · Journal of Child Neurology · doi:10.1177/0883073814550188 · Cited by 15

Authors: Singleton, J. R., Smith, A. G., Russell, J. W., & Feldman, E. L.
Affiliations: University of Utah (US)
University of Michigan (US)
ORCID: Singleton, J. Robinson
Russell, James W.
Feldman, Eva L.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2003-12-01
Volume: 52
Issue: 12
Pages: 2867-2873
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.52.12.2867
OpenAlex: W2012946594
Cited by: 372
References: 50
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 13 · 2021: 12 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 8 · 2015: 20 · 2014: 21 · 2013: 13 · 2012: 27
FWCI: 2.94
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs (NIH NS38849)
Deutsches Krebsforschungszentrum
National Institutes of Health (1r21ns041634-01)
National Institute of Neurological Disorders and Stroke (NS40458, R01NS038849, NS42065, R01NS036778, R21-NS-41634, R01NS040458, K02NS042056, NS 36778)
National Center for Research Resources (M01-RR00042NS38849, MO1-RR-00064, M01RR000064, M01RR000042)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: impaired glucose tolerance, microvascular complications, insulin resistance, cardiovascular risk, retinopathy, diabetic nephropathy, diabetic polyneuropathy, endothelial dysfunction, nitric oxide, adipokines, free fatty acids, prediabetes, diabetes prevention, diet and exercise intervention
MeSH terms: Diabetic Nephropathies, Diabetic Neuropathies, Diabetic Retinopathy, Humans, Microcirculation, Polyneuropathies, Glucose Intolerance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microvascular Complications of Impaired Glucose Tolerance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks