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Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic β-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes
Open accessAbstract
The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1) and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (KATP) channel, control insulin secretion. Common polymorphisms in these genes (ABCC8 exon 16–3t/c, exon 18 T/C, KCNJ11 E23K) have been variably associated with type 2 diabetes, but no large (∼2,000 subjects) case-control studies have been performed. We evaluated the role of these three variants by studying 2,486 U.K. subjects: 854 with type 2 diabetes, 1,182 population control subjects, and 150 parent-offspring type 2 diabetic trios. The E23K allele was associated with diabetes in the case-control study (odds ratio [OR] 1.18 [95% CI 1.04–1.34], P = 0.01) but did not show familial association with diabetes. Neither the exon 16 nor the exon 18 ABCC8 variants were associated with diabetes (1.04 [0.91–1.18], P = 0.57; 0.93 [0.71–1.23], P = 0.63, respectively). Meta-analysis of all case-control data showed that the E23K allele was associated with type 2 diabetes (K allele OR 1.23 [1.12–1.36], P = 0.000015; KK genotype 1.65 [1.34–2.02], P = 0.000002); but the ABCC8 variants were not associated. Our results confirm that E23K increases risk of type 2 diabetes and show that large-scale association studies are important for the identification of diabetes susceptibility alleles.
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“Moreover, different isoforms of the two subunits are expressed, depending on the tissue-specific expression of the KATP-channels: SUR1 and Kir6.2 are expressed in the pancreas and brain,296 Kir6.2 and SUR2A are expressed in the heart and skeletal muscle,297 while SUR2B is expressed in the brain and smooth muscle,298 and Kir6.1 and SUR2B are expressed in vascular smooth muscle.299”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [296]
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“Defects in ion channels underlie many major disorders in humans, also known as channelopathies, including neuronal disorders76, diabetes77 and heart failure78.”
From Unexplored therapeutic opportunities in the human genome (2018) · cites this paper as [77]
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“Finally, a common variant in Kir6.2 (E23K) is associated with a slightly increased risk of T2DM (216, 586). While its effects on KATP channel activity (604, 605) and insulin secretion (696) are very small (585) and controversial (552), it is important to note that even a tiny increase in channel activity can lead to ND (705).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [216]
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“unequivocal replications are so far limited to variants in just three genes: PPARG, KCNJ11 and TCF7L2 (2-4).”
From Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes (2007) · cites this paper as [3]
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“The other known T2D susceptibility variants were detected with effect sizes consistent with previous reports (2, 3).”
From Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes (2007) · cites this paper as [3]
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Cites
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766
A comprehensive review of genetic association studies
Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674
An efficient procedure for genotyping single nucleotide polymorphisms
Ye, S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.17.e88 · Cited by 1,013
Handbook of Human Genetic Linkage.
Edwards, A. W. F., Terwilliger, J. D., & Ott, J. (1996) · Biometrics · doi:10.2307/2533082 · Cited by 873
Association and Stoichiometry of KATP Channel Subunits
Clement, J. P., Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L., & Bryan, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80321-9 · Cited by 692
A Generalization of the Transmission/Disequilibrium Test for Uncertain-Haplotype Transmission
Clayton, D. G. (1999) · The American Journal of Human Genetics · doi:10.1086/302577 · Cited by 634
Linkage disequilibrium and the mapping of complex human traits.
Weiss, K., & Clark, A. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(01)02550-1 · Cited by 423
Keavney, B. D., McKenzie, C. A., Parish, S., Palmer, A., Clark, S. J., Youngman, L. D., Délepine, M., Lathrop, M. G., Peto, R., & Collins, R. (2000) · The Lancet · doi:10.1016/s0140-6736(00)82009-7 · Cited by 345
Wiltshire, S., Hattersley, A. T., Hitman, G. A., Walker, M., Lévy, J., Sampson, M., O’Rahilly, S., Frayling, T. M., Bell, J. I., Lathrop, M. G., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/323249 · Cited by 303
Self-citationHani, E. H., Boutin, P., Durand, E., Inoue, H., Permutt, M. A., Velho, G., & Froguel, P. (1998) · Diabetologia · doi:10.1007/s001250051098 · Cited by 268
Cited by
Sorted by citations
Items 501–600 of 753
Genetic Susceptibility to Type 2 Diabetes and Implications for Therapy
Florez, J. C. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300413 · Cited by 10
Yang, Y., Xu, J., Wang, Y. J., & Liu, X. (2015) · Genetics and Molecular Research · doi:10.4238/2015.august.21.13 · Cited by 8
Genetic Testing and Type 2 Diabetes Risk Awareness
de Groot, M., & Wessel, J. (2014) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721714527643 · Cited by 8
Rodríguez-Rivera, N. S., Cuautle-Rodríguez, P., Castillo‐Nájera, F., & Molina-Güarneros, J. (2017) · Biomedical Reports · doi:10.3892/br.2017.921 · Cited by 8
Diabetes and Renin-Angiotensin-Aldosterone System: Pathophysiology and Genetics
Nabi, A. H. M. N., & Ebihara, A. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97518 · Cited by 9
Liu, C., Lai, Y., Guan, T., Zhan, J., Pei, J., Wu, D., Ying, S., & Shen, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.816847 · Cited by 8
Pharmacogenetics of insulin secretagogue antidiabetics
Winkler, G., & Gerő, L. (2011) · Orvosi Hetilap · doi:10.1556/oh.2011.29175 · Cited by 8
van Hove, E. C., Hansen, T. F., Dekker, J. M., Reiling, E., Nijpels, G., Jørgensen, T., Borch‐Johnsen, K., Hamid, Y. H., Heine, R. J., Pedersen, O. B., et al. (2006) · Diabetes · doi:10.2337/db06-0414 · Cited by 8
Topić, E. (2013) · Journal of Medical Biochemistry · doi:10.2478/jomb-2013-0045 · Cited by 9
Pathophysiologie und Spätfolgen des Diabetes mellitus Typ 2
Reinehr, T. (2005) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-005-1224-0 · Cited by 7
Pharmacogenetics and individual responses to treatment of hyperglycemia in type 2 diabetes
Engelbrechtsen, L., Galijatovic, E. A. A., Roepstorff, S., Hansen, T. F., & Vestergaard, H. (2015) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000160 · Cited by 8
Engwa, G. A., Nwalo, F. N., Obi, C. E., Onyia, C. O., Mbacham, O. O. O., & Ubi, B. E. (2018) · Genetics and Molecular Research · doi:10.4238/gmr16039889 · Cited by 8
Genetic framework of type 2 diabetes mellitus
Бондарь, И. А., & Шабельникова, О. Ю. (2013) · Diabetes Mellitus · doi:10.14341/dm2013411-16 · Cited by 8
Do genome-wide association scans have potential for translation?
Lopes, M. C., Zeggini, E., & Panoutsopoulou, K. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.748 · Cited by 8
Genetic Regulation of the Variation in Pubertal Timing
Hodges, C. A., & Palmert, M. R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-499-5_4 · Cited by 8
Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes
Holmkvist, J., Almgren, P., Parikh, H. M., Zucchelli, M., Kere, J., Groop, L., & Lindgren, C. M. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201413 · Cited by 8
Li, L., Rojas, A., Wu, J.-P., & Jiang, C. (2004) · Endocrinology · doi:10.1210/en.2004-0285 · Cited by 8
Genetic contributions to Type 2 diabetes: recent insights
Sale, M. M., & Rich, S. S. (2007) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.7.2.207 · Cited by 8
Rout, M., Ramu, D., Mariana, M., Koshy, T., Venkatesan, V., López-Alvarenga, J. C., Arya, R., Ravichandran, U., Sharma, S. K., Lodha, S., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-00750-9 · Cited by 7
On the Verge of Precision Medicine in Diabetes
Li, J. H., & Florez, J. C. (2022) · Drugs · doi:10.1007/s40265-022-01774-4 · Cited by 8
Kamalıdehghan, B., Allahdini, M., Akbari, L., Azadfar, P., Rahmani, A., Ahmadipour, F., Houshmand, M., Meng, G. Y., & Masserrat, A. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s82485 · Cited by 7
Genome-Wide Association Studies of Type 2 Diabetes
SLADEK, R. M., & Prokopenko, I. (2016) · Springer eBooks · doi:10.1007/978-3-319-01574-3_2 · Cited by 7
Genetic Polymorphisms and Ischemic Heart Disease
Fedele, F., Pucci, M., & Severino, P. (2017) · InTech eBooks · doi:10.5772/intechopen.69621 · Cited by 6
Remedi, M. S., & Nichols, C. G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802002-9.00008-x · Cited by 9
KCNJ11 polymorphism is associated with type 2 diabetes mellitus in Iraqi patients
Muftin, N. Q., & Jubair, S. (2019) · Gene Reports · doi:10.1016/j.genrep.2019.100480 · Cited by 7
Blüher, M., & Stümvoll, M. (2020) · Endocrinology · doi:10.1007/978-3-030-36694-0_1 · Cited by 10
Maternal diabetes negatively impacts fetal health
Corona, C. G., & Parchem, R. J. (2022) · Open Biology · doi:10.1098/rsob.220135 · Cited by 8
Lee, I. S., Lee, J. H., Kim, H. J., Lee, J. M., Lee, S., Kim, H. S., Lee, J. M., Park, K. S., & Ku, B. J. (2013) · Europe PMC (PubMed Central) · doi:10.3233/dma-120949 · Cited by 7
Found in Translation: A Type 1 Diabetes Genetic Risk Score Applied to Clinical Diagnosis
Florez, J. C. (2016) · Diabetes Care · doi:10.2337/dci15-0029 · Cited by 8
Influence of i KCNJ11 i gene polymorphism in T2DM of south Indian population
Ramakrishnan, V. (2020) · Frontiers in Bioscience-Elite · doi:10.2741/e867 · Cited by 7
Electrophysiology of Islet Cells
Drews, G., Krippeit‐Drews, P., & Düfer, M. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_5 · Cited by 7
Genome-wide association studies for the identification of biomarkers in metabolic diseases
Pattin, K. A., & Moore, J. H. (2009) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530050903322245 · Cited by 7
de la Llana, S. A., Klee, P., Santoni, F. A., Stekelenburg, C., Blouin, J., & Schwitzgebel, V. (2015) · Hormone Research in Paediatrics · doi:10.1159/000437378 · Cited by 6
Wan, J., Jiang, X., Bai, J., She, Z., & Wang, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.070 · Cited by 6
Programming of DNA methylation in type 2 diabetes
Simmons, R. A. (2013) · Diabetologia · doi:10.1007/s00125-013-2866-4 · Cited by 6
Chen, T., Cao, X., Long, Y., Zhang, X., Yu, H., Xu, J., Yu, T., & Tian, H. (2010) · International Journal of Diabetes Mellitus · doi:10.1016/j.ijdm.2009.12.011 · Cited by 5
Genetics of type 2 diabetes in Arabs: What we know to date
Meyer, B. F., Alsmadi, O. A., Wakil, S. M., & Al-Rubeaan, K. A. (2009) · International Journal of Diabetes Mellitus · doi:10.1016/j.ijdm.2009.03.003 · Cited by 6
Abed, A. A., Ayesh, B. M., & Hamdona, O. M. (2013) · International Journal of Chemical and Life Sciences · Cited by 6
Development of the Pancreas and Neonatal Diabetes
Scharfmann, R., & Hamilton-Shield, J. P. (2007) · Endocrine development · doi:10.1159/isbn.978-3-8055-8386-2 · Cited by 7
Target identification and validation through genetics
Allen, M., & Carey, A. H. (2004) · Drug Discovery Today TARGETS · doi:10.1016/s1741-8372(04)02450-8 · Cited by 6
Identification of susceptibility genes loci associated with type 2 diabetes
Liu, L., Lei, J., Liu, H., Zou, Q., Sun, Y., Xu, Y., Bi, H., Deng, F., Shao, X., & Liu, S. M. (2010) · Wuhan University Journal of Natural Sciences · doi:10.1007/s11859-010-0216-7 · Cited by 6
Leahy, J. L., & Pratley, R. E. (2011) · Translational endocrinology & metabolism · doi:10.1210/team.9781879225824.ch1 · Cited by 5
Heianza, Y., & Qi, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802928-2.00029-1 · Cited by 6
Sapin, E., Keedwell, E. C., & Frayling, T. M. (2013) · Genetic and Evolutionary Computation Conference (GECCO) · doi:10.1145/2463372.2463410 · Cited by 5
Self-citationAl-Sinani, S., Hassan, M. O., Zadjali, F., Al‐Yahyaee, S., Albarwani, S., Rizvi, S. Z. H., Jaju, D., Comuzzie, A. G., Voruganti, V. S., & Bayoumi, R. (2014) · Gene · doi:10.1016/j.gene.2014.06.053 · Cited by 5
Chistiakov, D. A., Potapov, V. A., Khodirev, D. S., Шамхалова, М. Ш., Shestakova, M. V., & Nosikov, V. V. (2008) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2008.04.002 · Cited by 5
Mouse models of β-cell KATP channel dysfunction
Brereton, M. F., & Ashcroft, F. M. (2013) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2013.02.001 · Cited by 5
The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis
Rolim, A. L., Lindsey, S. C., Kunii, I. S., Crispim, F., Moisés, R. S., Maciel, R. M. B., & Dias-da-Silva, M. R. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0083 · Cited by 5
An insight into diabesity - A short review
Ananthappan, M., Nair, M., & Balaji, H. (2014) · International Journal of Medical Science and Public Health · doi:10.5455/ijmsph.2014.190220141 · Cited by 5
Pietrzak-Nowacka, M., Safranow, K., Bińczak‐Kuleta, A., Różański, J., Ciechanowski, K., & Ciechanowicz, A. (2012) · PubMed · doi:10.3265/nefrologia.pre2011.dec.10663 · Cited by 5
Jamaluddin, J. L., Huri, H. Z., Vethakkan, S. R., & Mustafa, N. (2014) · Pharmacogenomics · doi:10.2217/pgs.13.234 · Cited by 5
Yun, J. H., Yoo, M., Park, J. Y., Lee, H., & Park, S. I. (2021) · Scientific Reports · doi:10.1038/s41598-021-84179-9 · Cited by 5
Genetics of Gestational Diabetes Mellitus and Type 2 Diabetes
Watanabe, R. M. (2010) · Springer eBooks · doi:10.1007/978-1-84882-120-0_13 · Cited by 5
Type 2 Diabetes and Genetics, 2010: Translating Knowledge into Understanding
Walford, G. A., & Florez, J. C. (2010) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-010-0129-1 · Cited by 6
Pathogenesis of Type 2 Diabetes
Stümvoll, M., Goldstein, B., & van Haeften, T. W. (2007) · CRC Press eBooks · doi:10.3109/9780849379581-3 · Cited by 5
Islet Function and Insulin Secretion
Jones, P. M., & Persaud, S. J. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch6 · Cited by 5
Al-Rubeaan, K. A., Musambil, M., Wakil, S. M., Al‐Saud, H., Saeb, A. T. M., Al-Qasim, S., & Alnaqeb, D. (2018) · Gene · doi:10.1016/j.gene.2018.04.019 · Cited by 4
An, M., Akyüz, M., Çapik, Ö., Yalcin, C., Bertram, R., Karataş, E. A., Karataş, Ö. F., & Yildirim, V. (2024) · Mathematical Biosciences · doi:10.1016/j.mbs.2024.109224 · Cited by 4
Predisposition Factors of Type II Diabetes Mellitus and Related Complications
Cheekurthy, A. J., Babu, C. R., Kumar, A., & Surendrababu, K. (2014) · SpringerBriefs in applied sciences and technology · doi:10.1007/978-981-287-050-6_5 · Cited by 4
Sequencing genes in silico using single nucleotide polymorphisms
Zhang, X. C., Zhang, B., Li, S. S., Huang, X., Hansen, J. A., & Zhao, L. P. (2012) · BMC Genetics · doi:10.1186/1471-2156-13-6 · Cited by 4
Taylor, C. Y., Guillén, I., Nazábal, M., Fernández, J. R., & Silva, J. A. (2007) · PubMed Central · Cited by 4
Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00012-3 · Cited by 4
Transcription factor 7-like 2 (TCF7L2): a culprit gene in Type 2 Diabetes Mellitus
Jan, A., Jan, H., & Ullah, N. (2021) · Diabetes Mellitus · doi:10.14341/dm12313 · Cited by 4
Ren, Y., Zhu, W., Shi, J., Shao, A., Cheng, Y., & Liu, Y. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108170 · Cited by 4
Lu, Z., Zhang, H., Yang, Y., & Zhao, H. (2023) · Human Genetics · doi:10.1007/s00439-023-02573-x · Cited by 4
López-Orduña, E., Garcı́a-Mena, J., García-Macedo, R., Stümvoll, M., & Cruz, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.001 · Cited by 4
Evaluation of variant A45T in NEUROD1/BETA2 for its association with type 2 diabetes mellitus
Han, X., Xiao, J., Ren, Q., Tang, Y. C., Yang, W., & Ji, L. (2012) · Endocrine · doi:10.1007/s12020-012-9844-3 · Cited by 4
Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease
Sharma, A. R., & Vella, A. V. (2016) · Physiology · doi:10.1152/physiol.00009.2016 · Cited by 4
Dietary Phytochemicals and Their Potential Effects on Diabetes Mellitus 2
Singh, R., Kazmi, I. A., Afzal, M., Imam, F., & Alharbi, K. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-04408-4_4 · Cited by 4
Doi, Y., Kubo, M., Ninomiya, T., Yonemoto, K., Iwase, M., Arima, H., Hata, J., Tanizaki, Y., Iida, M., & Kiyohara, Y. (2007) · Diabetes · doi:10.2337/db07-1709 · Cited by 5
Arya, R., Puppala, S., Farook, V. S., Chittoor, G., Jenkinson, C. P., Blangero, J., Hale, D. E., Duggirala, R., & Almasy, L. A. (2015) · Springer eBooks · doi:10.1007/978-3-662-46306-2_12 · Cited by 4
Genetics of Diabetes and Diabetic Complications
Prasad, R. B., Ahlqvist, E., & Groop, L. (2018) · Endocrinology · doi:10.1007/978-3-319-45015-5_6 · Cited by 5
Pore blocking mechanisms of centipede toxin SsTx-4 on the inwardly rectifying potassium channels
Tang, D., Xu, J., Bao, W., Xu, F., Qi, J., Tan, Z., Li, C., Luo, X., You, X., Rong, M., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177213 · Cited by 3
Zhang, L., Kulkarni, P., Farshidfar, F., Tingley, W. G., Hoey, T., Wang, W., Priest, J. R., & Figarska, S. M. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04753-1 · Cited by 3
When and how to restore β-cell function?
Pancani, F., Lupi, R., Miccoli, R., Marchetti, P., & Prato, S. D. (2007) · International Congress Series · doi:10.1016/j.ics.2007.03.029 · Cited by 3
Hughes, A. E., Hayes, M. G., Egan, A. M., Patel, K. A., Scholtens, D. M., Lowe, L. P., Lowe, W. L., Dunne, F., Hattersley, A. T., & Freathy, R. M. (2020) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16097.1 · Cited by 3
Self-citationHughes, A. E., Hayes, M. G., Egan, A. M., Patel, K., Scholtens, D. M., Lowe, L. P., Lowe, W. L., Dunne, F., Hattersley, A. T., & Freathy, R. M. (2020) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16097.3 · Cited by 4
Self-citationChapter 1 Transcription factor genes in type 2 diabetes
Weedon, M. N., Hattersley, A. T., & Frayling, T. M. (2006) · Advances in molecular and cellular endocrinology · doi:10.1016/s1569-2566(06)05001-0 · Cited by 3
Self-citationFremskritt innen diabetesgenetikk
Njølstad, P. R., Hertel, J. K., Sövik, O., Ræder, H., Johansson, S., & Molven, A. (2010) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.09.1035 · Cited by 3
Type 2 Diabetes: Genetic Advance and Aetiology
Dehwah, M. A. S., Shuang, Z., Hua, W. Z., Min, W., & Huang, Q. (2009) · Journal of Applied Sciences · doi:10.3923/jas.2009.3407.3423 · Cited by 3
Genetic basis of type 2 diabetes--recommendations based on meta-analysis.
Li, J., Gong, Y. P., Cl, L., Yh, L., Liu, Y., & Yh, S. (2015) · PubMed · Cited by 3
Grant, S. F. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_11-1 · Cited by 3
Sapin, E., Keedwell, E. C., & Frayling, T. M. (2013) · Open Research Exeter (University of Exeter) · Cited by 3
Self-citationFlorez, J. C., Udler, M. S., & Hanson, R. L. (2021) · Europe PMC (PubMed Central) · Cited by 3
Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus
Remedi, M. S., Thomas, M., Nichols, C. G., & Marshall, B. A. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12489 · Cited by 3
Grant, S. F. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_11 · Cited by 4
Al-Khalayfa, S., Mashal, S., Khanfar, M., Srour, L., Mustafa, L., Battah, A., Zayed, A. A., Khader, Y. S., & Azab, B. (2023) · Human Gene · doi:10.1016/j.humgen.2023.201201 · Cited by 3
The Role of Pharmacogenomics in Diabetes
Lam, Y. W. F., Duggirala, R., Jenkinson, C. P., & Arya, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812626-4.00009-7 · Cited by 4
Blüher, M., & Stümvoll, M. (2018) · Endocrinology · doi:10.1007/978-3-319-44433-8_1 · Cited by 3
Yan, Y. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/kpne-0v56 · Cited by 3
Florez, J. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2204 · Cited by 3
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Self-citationAnalysis of key genes and pathways associated with the pathogenesis of Type 2 diabetes mellitusPreprint
Alur, V. C., Raju, V., Vastrad, B. M., Vastrad, C. M., & Kotrashetti, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.12.456106 · Cited by 3
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Metadata
- Authors
- Gloyn, A. L., Weedon, M. N., Owen, K. R., Turner, M. J., Knight, B. A., Hitman, G., Walker, M., Levy, J. C., Sampson, M., Halford, S., McCarthy, M. I., Hattersley, A. T., & Frayling, T. M.
- Affiliations
- Centre for Molecular Genetics, Peninsula Medical School, Exeter, U.K.
- University of London (GB)
- Newcastle University (GB)
- The Diabetes Research Laboratories, Radcliffe Infirmary, University of Oxford, Oxford, U.K.
- Norfolk and Norwich University Hospital (GB)
- Imperial College London (GB)
- Centre for Human Genetics (GB)
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-02-01
- Volume
- 52
- Issue
- 2
- Pages
- 568-572
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2169174186
- Cited by
- 754
- References
- 27
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 8 · 2023: 16 · 2022: 10 · 2021: 14 · 2020: 15 · 2019: 20 · 2018: 25 · 2017: 27 · 2016: 33 · 2015: 30 · 2014: 40 · 2013: 42 · 2012: 46
- FWCI
- 38.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 2 diabetes, KCNJ11, ABCC8, Kir6.2, SUR1, ATP-sensitive potassium channels, genetic susceptibility, insulin secretion, pancreatic beta cells, parent-offspring trios, familial association
- MeSH terms
- Adult, Alleles, Diabetes Mellitus, Type 2, Exons, Female, Genotype, Humans, Islets of Langerhans, Male, Middle Aged, Receptors, Drug, Genetic Variation, Potassium Channels, Cohort Studies, ATP-Binding Cassette Transporters, Amino Acid Substitution, Potassium Channels, Inwardly Rectifying, Sulfonylurea Receptors
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