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Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic β-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes
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The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1) and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (KATP) channel, control insulin secretion. Common polymorphisms in these genes (ABCC8 exon 16–3t/c, exon 18 T/C, KCNJ11 E23K) have been variably associated with type 2 diabetes, but no large (∼2,000 subjects) case-control studies have been performed. We evaluated the role of these three variants by studying 2,486 U.K. subjects: 854 with type 2 diabetes, 1,182 population control subjects, and 150 parent-offspring type 2 diabetic trios. The E23K allele was associated with diabetes in the case-control study (odds ratio [OR] 1.18 [95% CI 1.04–1.34], P = 0.01) but did not show familial association with diabetes. Neither the exon 16 nor the exon 18 ABCC8 variants were associated with diabetes (1.04 [0.91–1.18], P = 0.57; 0.93 [0.71–1.23], P = 0.63, respectively). Meta-analysis of all case-control data showed that the E23K allele was associated with type 2 diabetes (K allele OR 1.23 [1.12–1.36], P = 0.000015; KK genotype 1.65 [1.34–2.02], P = 0.000002); but the ABCC8 variants were not associated. Our results confirm that E23K increases risk of type 2 diabetes and show that large-scale association studies are important for the identification of diabetes susceptibility alleles.
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“Moreover, different isoforms of the two subunits are expressed, depending on the tissue-specific expression of the KATP-channels: SUR1 and Kir6.2 are expressed in the pancreas and brain,296 Kir6.2 and SUR2A are expressed in the heart and skeletal muscle,297 while SUR2B is expressed in the brain and smooth muscle,298 and Kir6.1 and SUR2B are expressed in vascular smooth muscle.299”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [296]
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“Defects in ion channels underlie many major disorders in humans, also known as channelopathies, including neuronal disorders76, diabetes77 and heart failure78.”
From Unexplored therapeutic opportunities in the human genome (2018) · cites this paper as [77]
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“Finally, a common variant in Kir6.2 (E23K) is associated with a slightly increased risk of T2DM (216, 586). While its effects on KATP channel activity (604, 605) and insulin secretion (696) are very small (585) and controversial (552), it is important to note that even a tiny increase in channel activity can lead to ND (705).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [216]
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“unequivocal replications are so far limited to variants in just three genes: PPARG, KCNJ11 and TCF7L2 (2-4).”
From Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes (2007) · cites this paper as [3]
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“The other known T2D susceptibility variants were detected with effect sizes consistent with previous reports (2, 3).”
From Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes (2007) · cites this paper as [3]
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Cites
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766
A comprehensive review of genetic association studies
Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674
An efficient procedure for genotyping single nucleotide polymorphisms
Ye, S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.17.e88 · Cited by 1,013
Handbook of Human Genetic Linkage.
Edwards, A. W. F., Terwilliger, J. D., & Ott, J. (1996) · Biometrics · doi:10.2307/2533082 · Cited by 873
Association and Stoichiometry of KATP Channel Subunits
Clement, J. P., Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L., & Bryan, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80321-9 · Cited by 692
A Generalization of the Transmission/Disequilibrium Test for Uncertain-Haplotype Transmission
Clayton, D. G. (1999) · The American Journal of Human Genetics · doi:10.1086/302577 · Cited by 634
Linkage disequilibrium and the mapping of complex human traits.
Weiss, K., & Clark, A. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(01)02550-1 · Cited by 423
Keavney, B. D., McKenzie, C. A., Parish, S., Palmer, A., Clark, S. J., Youngman, L. D., Délepine, M., Lathrop, M. G., Peto, R., & Collins, R. (2000) · The Lancet · doi:10.1016/s0140-6736(00)82009-7 · Cited by 345
Wiltshire, S., Hattersley, A. T., Hitman, G. A., Walker, M., Lévy, J., Sampson, M., O’Rahilly, S., Frayling, T. M., Bell, J. I., Lathrop, M. G., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/323249 · Cited by 303
Self-citationHani, E. H., Boutin, P., Durand, E., Inoue, H., Permutt, M. A., Velho, G., & Froguel, P. (1998) · Diabetologia · doi:10.1007/s001250051098 · Cited by 268
Cited by
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Items 101–200 of 753
Electrophysiology of Islet Cells
Drews, G., Krippeit-Drews, P., & Düfer, M. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-90-481-3271-3_7 · Cited by 152
Learning From Molecular Genetics
McCarthy, M. I., & Hattersley, A. T. (2008) · Diabetes · doi:10.2337/db08-0343 · Cited by 132
Self-citationIdentification of Type 2 Diabetes Genes in Mexican Americans Through Genome-Wide Association Studies
Hayes, M. G., Pluzhnikov, A., Miyake, K., Sun, Y., Ng, M. C. Y., Roe, C. A., Below, J. E., Nicolae, R. I., Konkashbaev, A. I., Bell, G. I., et al. (2007) · Diabetes · doi:10.2337/db07-0482 · Cited by 129
Wen, J., Rönn, T., Olsson, A., Yang, Z., Lu, B., Du, Y., Groop, L., Ling, C., & Ren-ming, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009153 · Cited by 124
Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose Homeostasis
Jin, T. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1146 · Cited by 132
TCF7L2: the biggest story in diabetes genetics since HLA?
Zeggini, E., & McCarthy, M. I. (2006) · Diabetologia · doi:10.1007/s00125-006-0507-x · Cited by 129
Self-citationNew insights into KATP channel gene mutations and neonatal diabetes mellitus
Pipatpolkai, T., Usher, S., Stansfeld, P. J., & Ashcroft, F. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0351-y · Cited by 122
Gaulton, K. J., Willer, C. J., Li, Y., Scott, L. J., Conneely, K. N., Jackson, A., Duren, W. L., Chines, P. S., Narisu, N., Bonnycastle, L. L., et al. (2008) · Diabetes · doi:10.2337/db07-1731 · Cited by 125
Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?
Gough, S. C. L., & O’Donovan, M. C. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105058380 · Cited by 121
Yorifuji, T., Nagashima, K., Kurokawa, K., Kawai, M., Oishi, M., Akazawa, Y., Hosokawa, M., Yamada, Y., Inagaki, N., & Nakahata, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0096 · Cited by 118
Hattersley, A. T., & Pearson, E. R. (2006) · Endocrinology · doi:10.1210/en.2006-0152 · Cited by 118
Self-citationGenome-wide association studies and type 2 diabetes
Wheeler, E., & Barroso, I. (2011) · Briefings in Functional Genomics · doi:10.1093/bfgp/elr008 · Cited by 119
Florez, J. C., Jablonski, K. A., Kahn, S. E., Franks, P. W., Dabelea, D., Hamman, R. F., Knowler, W. C., Nathan, D. M., & Altshuler, D. (2007) · Diabetes · doi:10.2337/db06-0966 · Cited by 119
Tinker, A., Aziz, Q. H., & Thomas, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12407 · Cited by 118
Hamming, K. S. C., Soliman, D., Matemisz, L. C., Niazi, O., Lang, Y. V., Gloyn, A. L., & Light, P. E. (2009) · Diabetes · doi:10.2337/db09-0143 · Cited by 117
Self-citationNew gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function
Perry, J. R. B., & Frayling, T. M. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32830349a1 · Cited by 119
Self-citationZeng, H., Guo, M. A., Zhou, T., Tan, L., Chong, C. N., Zhang, T., Dong, X., Xiang, J., Yu, A. S., Yue, L., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.07.002 · Cited by 111
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes
Barroso, I., Luan, J., Sandhu, M. S., Franks, P. W., Crowley, V., Schafer, A. J., O’Rahilly, S., & Wareham, N. J. (2006) · Diabetologia · doi:10.1007/s00125-005-0130-2 · Cited by 117
The Genetics of Type 2 Diabetes: A Realistic Appraisal in 2008
Florez, J. C. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1345 · Cited by 118
Human KATP channelopathies: diseases of metabolic homeostasis
Olson, T. M., & Terzic, A. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0771-y · Cited by 112
Genetics of Type 2 Diabetes: Insights into the Pathogenesis and Its Clinical Application
Sun, X., Yu, W., & Hu, C. (2014) · BioMed Research International · doi:10.1155/2014/926713 · Cited by 117
Imamura, M., Maeda, S., Yamauchi, T., Hara, K., Yasuda, K., Morizono, T., Takahashi, A., Horikoshi, M., Nakamura, M., Fujita, H., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds113 · Cited by 112
KATP channels and insulin secretion: a key role in health and disease
Ashcroft, F. M. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340243 · Cited by 112
Familial Clustering of Chronic Kidney Disease
Satko, S. G., Sedor, J. R., Iyengar, S. K., & Freedman, B. I. (2007) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2007.00282.x · Cited by 108
Gloyn, A. L., Siddiqui, J., & Ellard, S. (2006) · Human Mutation · doi:10.1002/humu.20292 · Cited by 111
Self-citationThe success of the genome-wide association approach: a brief story of a long struggle
Seng, K. C., & Seng, C. K. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.12 · Cited by 111
The new type 2 diabetes gene TCF7L2
Florez, J. C. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3281e2c9be · Cited by 107
Progress in the genetics of common obesity and type 2 diabetes
Vimaleswaran, K. S., & Loos, R. J. F. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001389 · Cited by 108
Iwata, M., Maeda, S., Kamura, Y., Takano, A., Kato, H., Murakami, S., Higuchi, K., Takahashi, A., Fujita, H., Hara, K., et al. (2012) · Diabetes Care · doi:10.2337/dc11-2006 · Cited by 105
Sale, M. M., Smith, S. G., Mychaleckyj, J. C., Keene, K. L., Langefeld, C. D., Leak, T. S., Hicks, P. J., Bowden, D. W., Rich, S. S., & Freedman, B. I. (2007) · Diabetes · doi:10.2337/db07-0012 · Cited by 105
Toward Linking Structure With Function in ATP-Sensitive K+ Channels
Bryan, J., Vila‐Carriles, W. H., Zhao, G., Babenko, A. P., & Aguilar‐Bryan, L. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s104 · Cited by 109
Sakamoto, Y., Inoue, H., Keshavarz, P., Miyawaki, K., Yamaguchi, Y., Moritani, M., Kunika, K., Nakamura, N., Yoshikawa, T., Yasui, N., et al. (2007) · Journal of Human Genetics · doi:10.1007/s10038-007-0190-x · Cited by 105
Neonatal Diabetes and the K ATP Channel: From Mutation to Therapy
Ashcroft, F. M., Puljung, M. C., & Vedovato, N. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.02.003 · Cited by 106
Genetic predisposition to type 2 diabetes among Asian Indians.
Radha, V., & Mohan, V. (2007) · PubMed · Cited by 101
Diabetes in China: epidemiology, pathophysiology and multi-omics
Jia, W., Chan, J. C. N., Wong, T. Y., & Fisher, E. B. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01190-w · Cited by 108
Type 2 diabetes mellitus: not quite exciting enough?
Ashcroft, F. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh066 · Cited by 102
Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine
Mannino, G. C., Andreozzi, F., & Sesti, G. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3109 · Cited by 108
Jonsson, A. E., Ladenvall, C., Ahluwalia, T. S., Kravić, J., Krus, U., Taneera, J., Isomaa, B., Tuomilehto, J., Renström, E., Groop, L., et al. (2013) · Diabetes · doi:10.2337/db12-1627 · Cited by 98
Identification of Type 2 Diabetes-associated combination of SNPs using Support Vector Machine
Ban, H., Heo, J. Y., Oh, K.-S., & Park, K.-J. (2010) · BMC Genetics · doi:10.1186/1471-2156-11-26 · Cited by 97
Hanson, R. L., Bogardus, C., Duggan, D. J., Kobes, S., Knowlton, M., Infante, A. M., Marovich, L., Benitez, D. S., Baier, L. J., & Knowler, W. C. (2007) · Diabetes · doi:10.2337/db07-0462 · Cited by 98
Saadi, H., Nagelkerke, N. J. D., Carruthers, S. G., Benedict, S., Abdulkhalek, S., Reed, R. L., Lukić, M. L., & Nicholls, M. G. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.01.008 · Cited by 97
ATP-sensitive K + channels and disease: from molecule to malady
Ashcroft, F. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00348.2007 · Cited by 107
Pharmacogenetics of Anti-Diabetes Drugs
DiStefano, J. K., & Watanabe, R. M. (2010) · Pharmaceuticals · doi:10.3390/ph3082610 · Cited by 96
KCNJ11 gene E23K variant and therapeutic response to sulfonylureas
Javorský, M., Klimčáková, L., Schroner, Z., Židzik, J., Babjaková, E., Fabianová, M., Kozárová, M., Tkáčová, R., Salagovic, J., & Tkáč, I. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.10.018 · Cited by 95
Weedon, M. N., Owen, K. R., Shields, B. M., Hitman, G. A., Walker, M., McCarthy, M. I., Love-Gregory, L. D., Permutt, M. A., Hattersley, A. T., & Frayling, T. M. (2004) · Diabetes · doi:10.2337/diabetes.53.11.3002 · Cited by 95
Self-citationCandidate Genes for Type 2 Diabetes
Parikh, H. M., & Groop, L. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000021437.46773.26 · Cited by 94
Elbein, S. C., Chu, W. S., Das, S. K., Yao‐Borengasser, A., Hasstedt, S. J., Wang, H., Rasouli, N., & Kern, P. A. (2007) · Diabetologia · doi:10.1007/s00125-007-0717-x · Cited by 93
Genetics of Ovarian Disorders: Polycystic Ovary Syndrome
Franks, S., & McCarthy, M. I. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000016125.05878.96 · Cited by 94
Self-citationGenome-wide association with diabetes-related traits in the Framingham Heart Study
Meigs, J. B., Manning, A. K., Fox, C. S., Florez, J. C., Liu, C., Cupples, L. A., & Dupuis, J. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s16 · Cited by 94
SORCS1: A Novel Human Type 2 Diabetes Susceptibility Gene Suggested by the Mouse
Goodarzi, M. O., Lehman, D. M., Taylor, K. D., Guo, X., Cui, J., Quiñones, M. J., Clee, S. M., Yandell, B. S., Blangero, J., Hsueh, W. A., et al. (2007) · Diabetes · doi:10.2337/db06-1677 · Cited by 89
Li, M., Kwan, J. S. H., & Sham, P. C. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.08.004 · Cited by 93
TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden
Mayans, S., Lackovic, K., Lindgren, P., Ruikka, K., Ågren, Å., Eliasson, M., & Holmberg, D. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201773 · Cited by 90
Genomics of type 2 diabetes mellitus: implications for the clinician
Stolerman, E. S., & Florez, J. C. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.129 · Cited by 91
Common variants in HNF-1 α and risk of type 2 diabetes
Holmkvist, J., Cervin, C., Lyssenko, V., Winckler, W., Anevski, D., Cilio, C., Almgren, P.-E., Berglund, G., Nilsson, P. M., Tuomilehto, J., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0450-x · Cited by 95
Yokoi, N., Kanamori, M., Horikawa, Y., Takeda, J., Sanke, T., Furuta, H., Nanjo, K., Mori, H., Kasuga, M., Hara, K., et al. (2006) · Diabetes · doi:10.2337/db05-1203 · Cited by 91
Lin, Y., Li, P., Li, C., Zhang, B., Tang, X., Zhang, X., Li, Y., Yang, X. Q., Yang, Y., Wang, L., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-97 · Cited by 87
Slingerland, A. S., & Hattersley, A. T. (2005) · Annals of Medicine · doi:10.1080/07853890510007287 · Cited by 87
Self-citationvan Dam, R. M., Hoebee, B., Seidell, J. C., Schaap, M. M., de Bruin, T. W., & Feskens, E. J. M. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01465.x · Cited by 89
TCF7L2 genetic defect and type 2 diabetes
Cauchi, S., & Froguel, P. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0026-x · Cited by 91
Weedon, M. N., Shields, B. M., Hitman, G. A., Walker, M., McCarthy, M. I., Hattersley, A. T., & Frayling, T. M. (2006) · Diabetes · doi:10.2337/db06-0410 · Cited by 88
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Association of DLG5 R30Q variant with inflammatory bowel disease
Daly, M. J., Pearce, A. V., Farwell, L. M., Fisher, S. A., Latiano, A., Prescott, N. J., Forbes, A., Mansfield, J. C., Sanderson, J. D., Langelier, D., et al. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201403 · Cited by 86
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Koo, B. K., Cho, Y., Park, B. L., Cheong, H. S., Shin, H. D., Jang, H. C., Kim, S. Y., Lee, H. K., & Park, K. S. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.02050.x · Cited by 85
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Laakso, M., & Silva, L. F. (2022) · Nutrients · doi:10.3390/nu14153201 · Cited by 95
Review article: diabetes, genetics and ethnicity
Carulli, L., Rondinella, S., Lombardini, S., Canedi, I., LORIA, P., & Carulli, N. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02588.x · Cited by 87
Sarikonda, G., Pettus, J., Phatak, S., Sachithanantham, S., Miller, J. F., Wesley, J. D., Cadag, E., Chae, J., Ganesan, L., Mallios, R., et al. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.12.003 · Cited by 84
Florez, J. C., Sjögren, M., Burtt, N. P., Orho‐Melander, M., Schayer, S., Sun, M. W., Almgren, P., Lindblad, U., Tuomi, T., Gaudet, D., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3313 · Cited by 84
Common Variants in Maturity-Onset Diabetes of the Young Genes and Future Risk of Type 2 Diabetes
Holmkvist, J., Almgren, P., Lyssenko, V., Lindgren, C. M., Eriksson, K., Isomaa, B., Tuomilehto, J., Nilsson, P. M., & Groop, L. (2008) · Diabetes · doi:10.2337/db06-1464 · Cited by 85
Liu, Y., Zhou, D., Zhang, D., Chen, Z., Zhao, T., Zhang, Z., Ning, M., Hu, X., Yang, Y., Zhang, Z., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1375-y · Cited by 85
Villareal, D. T., Koster, J. C., Robertson, H., Akrouh, A., Miyake, K., Bell, G. I., Patterson, B. W., Nichols, C. G., & Polonsky, K. S. (2009) · Diabetes · doi:10.2337/db09-0025 · Cited by 83
Laukkanen, O., Pihlajamäki, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne‐Parikka, P., Keinanen-Kiukaanniemi, S. M., Tuomilehto, J. O., Uusitupa, M. I. J., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1204 · Cited by 82
Genetic Basis of Maturity-Onset Diabetes of the Young
Vaxillaire, M., & Froguel, P. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.02.009 · Cited by 81
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants
Mohlke, K. L., Boehnke, M., & Abecasis, G. R. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn275 · Cited by 82
Wang, X., Strizich, G., Hu, Y., Wang, T., Kaplan, R. C., & Qi, Q. (2015) · Journal of Diabetes · doi:10.1111/1753-0407.12323 · Cited by 84
Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes
Riedel, M. J., Steckley, D., & Light, P. E. (2004) · Human Genetics · doi:10.1007/s00439-004-1216-5 · Cited by 79
Nelson, P. T., Jicha, G. A., Wang, W., Ighodaro, E. T., Artiushin, S., Nichols, C. G., & Fardo, D. W. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.07.007 · Cited by 85
Owen, K. R., & McCarthy, M. I. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.04.003 · Cited by 82
Self-citationMachiela, M. J., Lindström, S., Allen, N. E., Haiman, C. A., Albanes, D., Barricarte, A., Berndt, S. I., Bueno-de-Mesquita, H. B., Chanock, S. J., Gaziano, J. M., et al. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws191 · Cited by 81
Basile, K. J., Johnson, M. E., Xia, Q., & Grant, S. F. A. (2014) · International Journal of Endocrinology · doi:10.1155/2014/769671 · Cited by 78
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The search for type 2 diabetes genes
Gloyn, A. L. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00061-2 · Cited by 77
Self-citationWeak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population
Alsmadi, O. A., Al-Rubeaan, K. A., Mohamed, G., Alkayal, F., Al‐Saud, H., Al‐Saud, N. A., Al‐Daghri, N. M., Mohammad, S., & Meyer, B. F. (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-72 · Cited by 80
Genetic Architecture of Type 2 Diabetes: Recent Progress and Clinical Implications
Grant, R. W., Moore, A. F., & Florez, J. C. (2009) · Diabetes Care · doi:10.2337/dc08-2171 · Cited by 75
Miyake, K., Yang, W., Hara, K., Yasuda, K., Horikawa, Y., Osawa, H., Furuta, H., Ng, M. C. Y., Hirota, Y., Mori, H., et al. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.17 · Cited by 74
Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels
Severino, P., D’Amato, A., Netti, L., Pucci, M., Marchis, M. D., Palmirotta, R., Volterrani, M., Mancone, M., & Fedele, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030802 · Cited by 82
β‐cell mass in people with type 2 diabetes
Cho, J., Kim, J., Shin, J., Shin, J., & Yoon, K. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00072.x · Cited by 69
Sanghera, D. K., Nath, S. K., Ortega, L., Gambarelli, M., Kim-Howard, X., Singh, J. R., Ralhan, S. K., Wander, G. S., Mehra, N. K., Mulvihill, J. J., et al. (2008) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2008.00443.x · Cited by 73
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Cui, B., Zhu, X., Xu, M., Guo, T., Zhu, D., Chen, G., Li, X., Xu, L., Bi, Y., Chen, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022353 · Cited by 72
Tarasov, A. I., Nicolson, T. J., Riveline, J., Taneja, T. K., Baldwin, S. A., Baldwin, J. M., Charpentier, G., Gautier, J., Froguel, P., Vaxillaire, M., et al. (2008) · Diabetes · doi:10.2337/db07-1547 · Cited by 72
Wabitsch, M., Lahr, G., van de Bunt, M., Marchant, C., Lindner, M. S., Puttkamer, J. V., Fenneberg, A., Debatin, K., Klein, R., Ellard, S., et al. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02285.x · Cited by 69
Self-citationThe search for putative unifying genetic factors for components of the metabolic syndrome
Sjögren, M., Lyssenko, V., Jonsson, A. E., Berglund, G., Nilsson, P., Groop, P., & Orho‐Melander, M. (2008) · Diabetologia · doi:10.1007/s00125-008-1151-4 · Cited by 69
Type 2 diabetes and obesity: genomics and the clinic
Travers, M. E., & McCarthy, M. I. (2011) · Human Genetics · doi:10.1007/s00439-011-1023-8 · Cited by 70
Self-citationType 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight
Galijatovic, E. A. A., Pilgaard, K. A., Pisinger, C. H., Harder, M. N., Grarup, N., Færch, K., Poulsen, P., Witte, D. R., Jørgensen, T., Vaag, A. A., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1790-0 · Cited by 74
Zhou, D., Zhang, D., Liu, Y., Zhao, T., Chen, Z., Liu, Z., Yu, L., Zhang, Z., Xu, H., & He, L. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.54 · Cited by 67
Klupa, T., Edghill, E. L., Nazim, J., Sieradzki, J., Ellard, S., Hattersley, A. T., & Malecki, M. T. (2005) · Diabetologia · doi:10.1007/s00125-005-1731-5 · Cited by 67
Self-citationMorgan, A. R., Thompson, J., Murphy, R., Black, P., Lam, W.-J., Ferguson, L. R., & Mitchell, E. A. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-125 · Cited by 70
Effects of body weight and alcohol consumption on insulin sensitivity
Paulson, Q. X., Hong, J., Holcomb, V. B., & Núñez, N. P. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-14 · Cited by 65
Laukkanen, O., Pihlajamki, J., Lindstr�m, J., Eriksson, J. G., Valle, T. T., H�m�l�inen, H., Ilanne‐Parikka, P., Kein�nen-Kiukaanniemi, S., Tuomilehto, J. O., Uusitupa, M. I. J., et al. (2004) · Diabetologia · doi:10.1007/s00125-004-1395-6 · Cited by 64
Metadata
- Authors
- Gloyn, A. L., Weedon, M. N., Owen, K. R., Turner, M. J., Knight, B. A., Hitman, G., Walker, M., Levy, J. C., Sampson, M., Halford, S., McCarthy, M. I., Hattersley, A. T., & Frayling, T. M.
- Affiliations
- Centre for Molecular Genetics, Peninsula Medical School, Exeter, U.K.
- University of London (GB)
- Newcastle University (GB)
- The Diabetes Research Laboratories, Radcliffe Infirmary, University of Oxford, Oxford, U.K.
- Norfolk and Norwich University Hospital (GB)
- Imperial College London (GB)
- Centre for Human Genetics (GB)
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-02-01
- Volume
- 52
- Issue
- 2
- Pages
- 568-572
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2169174186
- Cited by
- 754
- References
- 27
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 8 · 2023: 16 · 2022: 10 · 2021: 14 · 2020: 15 · 2019: 20 · 2018: 25 · 2017: 27 · 2016: 33 · 2015: 30 · 2014: 40 · 2013: 42 · 2012: 46
- FWCI
- 38.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 2 diabetes, KCNJ11, ABCC8, Kir6.2, SUR1, ATP-sensitive potassium channels, genetic susceptibility, insulin secretion, pancreatic beta cells, parent-offspring trios, familial association
- MeSH terms
- Adult, Alleles, Diabetes Mellitus, Type 2, Exons, Female, Genotype, Humans, Islets of Langerhans, Male, Middle Aged, Receptors, Drug, Genetic Variation, Potassium Channels, Cohort Studies, ATP-Binding Cassette Transporters, Amino Acid Substitution, Potassium Channels, Inwardly Rectifying, Sulfonylurea Receptors
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