The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine
Open accessAbstract
Accumulation of triosephosphates arising from high cytosolic glucose concentrations in hyperglycemia is the trigger for biochemical dysfunction leading to the development of diabetic nephropathy—a common complication of diabetes associated with a high risk of cardiovascular disease and mortality. Here we report that stimulation of the reductive pentosephosphate pathway by high-dose therapy with thiamine and the thiamine monophosphate derivative benfotiamine countered the accumulation of triosephosphates in experimental diabetes and inhibited the development of incipient nephropathy. High-dose thiamine and benfotiamine therapy increased transketolase expression in renal glomeruli, increased the conversion of triosephosphates to ribose-5-phosphate, and strongly inhibited the development of microalbuminuria. This was associated with decreased activation of protein kinase C and decreased protein glycation and oxidative stress—three major pathways of biochemical dysfunction in hyperglycemia. Benfotiamine also inhibited diabetes-induced hyperfiltration. This was achieved without change in elevated plasma glucose concentration and glycated hemoglobin in the diabetic state. High-dose thiamine and benfotiamine therapy is a potential novel strategy for the prevention of clinical diabetic nephropathy.
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Mechanisms of Diabetic Complications
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Diabetic nephropathy: diagnosis, prevention, and treatment
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The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
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Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
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Metadata
- Authors
- Babaei-Jadidi, R., Karachalias, N., Ahmed, N., Battah, S., & Thornalley, P. J.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2003-08-01
- Volume
- 52
- Issue
- 8
- Pages
- 2110-2120
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2123438808
- Cited by
- 373
- References
- 34
- FWCI
- 13.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Babaei-Jadidi, R., Karachalias, N., Ahmed, N., Battah, S., & Thornalley, P. J. (2003). Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine. Diabetes. https://doi.org/10.2337/diabetes.52.8.2110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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