Cited by 273Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancerMuscle Physiology and Disorders

The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.

Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity

Bruss, Matthew D., Arias, Edward B., Lienhard, Gustav E., Cartee, Gregory D.·2005·Diabetes

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Abstract

In 3T3-L1 adipocytes, insulin-stimulated GLUT4 translocation requires phosphorylation of the protein designated Akt substrate of 160 kDa (AS160). Both insulin and contractions activate Akt in skeletal muscle. Therefore, we assessed the effects in skeletal muscle of each stimulus on phosphorylation of proteins, including AS160, on the Akt phosphomotif. Isolated rat epitrochlearis muscles were incubated with insulin (for time course and dose response), stimulated to contract, or incubated with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) and used to assess the following: serine-phosphorylation of Akt (P-Akt), immunoreactivity with an antibody recognizing the Akt phosphomotif (α-phospho-[Ser/Thr] Akt substrate [PAS]), and PAS immunoreactivity of samples immunoprecipitated with anti-AS160. P-Akt peaked at 5 min of insulin, and PAS immunoreactivity subsequently peaked for proteins of 250 kDa (10 min) and 160 kDa (15 min). P-Akt, PAS-160, and PAS-250 increased significantly with 0.6 nmol/l insulin. Contractile activity led to increased P-Akt and PAS immunoreactivity of proteins of 160 and 250 kDa. The 160-kDa protein was confirmed to be AS160 based on elevated PAS immunoreactivity in AS160 immunoprecipitates. Wortmannin inhibited insulin (120 nmol/l) and contraction effects on AS160 phosphorylation. Incubation with AICAR caused increased phosphorylation of AMP-activated protein kinase and AS160 but not Akt. Our working hypothesis is that phosphorylation of these putative Akt substrates is important for some of the insulin and contraction bioeffects.

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Dan, H. C., Sun, M., Yang, L., Feldman, R. I., Sui, X.-M., Ou, C. C., Nellist, M. D., Yeung, R. S. W., Halley, D. J. J., Nicosia, S. V., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205838200 · Cited by 370
Retracted
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
Specificity and mechanism of action of some commonly used protein kinase inhibitors
DAVIES, S. P., Reddy, H., Caivano, M., & Cohen, P. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510095 · Cited by 4,372
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555
PKB/Akt
Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,068
The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways
Fryer, L. G. D., Patel, A. P., & Carling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202489200 · Cited by 1,035
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation
Sano, H., Kane, S., Sano, E., Mı̂inea, C. P., Asara, J. M., Lane, W. S., Garner, C. W., & Lienhard, G. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300063200 · Cited by 964
Self-citation
Signaling pathways in insulin action: molecular targets of insulin resistance
Pessin, J. E., & Saltiel, A. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10582 · Cited by 939
Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes · doi:10.2337/diabetes.47.8.1369 · Cited by 774

Show all 30 references

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Lockhart, N. C., Baar, K., Mazzeo, R. S., & Brooks, S. V. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000222832.43520.27 · Cited by 6
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Matthäus, D. (2014) · doi:10.18452/16905 · Cited by 1
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Egan, B. (2008) · Dublin City University Open Access Institutional Repository (Dublin City University)
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Kurauti, M. A. (2015) · doi:10.47749/t/unicamp.2015.943073
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Newsom, S. A. (2012)
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Glund, S. (2007) · Figshare
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Kleiman, E. (2009) · Digital Commons - University of South Florida (University of South Florida)
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Rodrigues, S. C. (2011) · doi:10.11606/d.42.2011.tde-07102011-163331
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Sharma, M., & Dey, C. S. (2022) · Figshare · doi:10.6084/m9.figshare.21557546
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Authors: Bruss, M. D., Arias, E. B., Lienhard, G. E., & Cartee, G. D.
Affiliations: University of Wisconsin–Madison (US)
University of Michigan (US)
Dartmouth College (US)
ORCID: Arias, Edward B.
Cartee, Gregory D.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2005-01-01
Volume: 54
Issue: 1
Pages: 41-50
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.54.1.41
OpenAlex: W2148321229
Cited by: 273
References: 30
Citations by year: 2025: 2 · 2023: 1 · 2022: 14 · 2021: 9 · 2020: 5 · 2019: 10 · 2018: 11 · 2017: 7 · 2016: 7 · 2015: 16 · 2014: 16 · 2013: 11 · 2012: 20
FWCI: 9.97
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG 10026)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK025336, DK-25336, R56DK042816)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: AS160, Akt phosphorylation, skeletal muscle, insulin signaling, muscle contraction, GLUT4 translocation, AMPK, wortmannin, epitrochlearis muscle
MeSH terms: Aminoimidazole Carboxamide, Animals, Insulin, Kinetics, Male, Muscle Contraction, Muscle Proteins, Phosphorylation, Proto-Oncogene Proteins, Ribonucleotides, Rats, Wistar, Protein Serine-Threonine Kinases, Muscle, Skeletal, Proto-Oncogene Proteins c-akt, Rats

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Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity

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