The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Apical GLUT2
Open accessAbstract
Understanding the mechanisms that determine postprandial fluctuations in blood glucose concentration is central for effective glycemic control in the management of diabetes. Intestinal sugar absorption is one such mechanism, and studies on its increase in experimental diabetes led us to propose a new model of sugar absorption. In the apical GLUT2 model, the glucose transported by the Na+/glucose cotransporter SGLT1 promotes insertion of GLUT2 into the apical membrane within minutes, so that the mechanism operates during assimilation of a meal containing high–glycemic index carbohydrate to provide a facilitated component of absorption up to three times greater than by SGLT1. Here we review the evidence for the apical GLUT2 model and describe how apical GLUT2 is a target for multiple short-term nutrient-sensing mechanisms by dietary sugars, local and endocrine hormones, cellular energy status, stress, and diabetes. These mechanisms suggest that apical GLUT2 is a potential therapeutic target for novel dietary or pharmacological approaches to control intestinal sugar delivery and thereby improve glycemic control.
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Cites
Dietary and developmental regulation of intestinal sugar transport
FERRARIS, R. P. (2001) · Biochemical Journal · doi:10.1042/bj3600265 · Cited by 328
DIMITRIADIS, G., LEIGHTON, B., PARRY-BILLINGS, M., SASSON, S., YOUNG, M., KRAUSE, U., BEVAN, S., PIVA, T., WEGENER, G., & NEWSHOLME, E. A. (1997) · Biochemical Journal · doi:10.1042/bj3210707 · Cited by 266
Cited by
Biology of Human Sodium Glucose Transporters
Wright, E. M., Loo, D. D. F., & Hirayama, B. A. (2011) · Physiological Reviews · doi:10.1152/physrev.00055.2009 · Cited by 1,430
Gorboulev, V., Schürmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., Friedrich, A., Scherneck, S., Rieg, T., Cunard, R., et al. (2012) · Diabetes · doi:10.2337/db11-1029 · Cited by 687
Role of polysaccharides in food, digestion, and health
Lovegrove, A., Edwards, C. H., De Noni, I., Patel, H., El, S. N., Grassby, T., Zielke, C., Ulmius, M., Nilsson, L., Butterworth, P. J., et al. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.939263 · Cited by 606
“When food enters the stomach, the gastric pH will rise to approximate the original pH of the food when it was ingested, then gradually drop to pH 2.0 towards the end of gastric digestion (Malagelada et al., 1976).”
BackgroundInfluentialFunctional Properties and Genomics of Glucose Transporters
Zhao, F.-Q., & Keating, A. (2007) · Current Genomics · doi:10.2174/138920207780368187 · Cited by 549
Inhibition of the intestinal glucose transporter GLUT2 by flavonoids
Kwon, O., Eck, P., Chen, S., Corpe, C. P., Lee, J., Kruhlak, M., & Levine, M. (2007) · The FASEB Journal · doi:10.1096/fj.06-6620com · Cited by 450
Metadata
- Authors
- Kellett, G. L., & Brot-Laroche, E.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-10-01
- Volume
- 54
- Issue
- 10
- Pages
- 3056-3062
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2134948484
- Cited by
- 350
- References
- 2
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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