The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Liver Markers and Development of the Metabolic Syndrome
Abstract
Nonalcoholic fatty liver disease (NAFLD) is emerging as a component of the metabolic syndrome, although it is not known whether markers of NAFLD, including elevated concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALK), predict the development of metabolic syndrome. Our objective was to investigate the associations of elevated AST, ALT, and other liver markers, including C-reactive protein (CRP), with incident National Cholesterol Education Program–defined metabolic syndrome among 633 subjects in the Insulin Resistance Atherosclerosis Study who were free of metabolic syndrome at baseline. Insulin sensitivity (Si) and acute insulin response (AIR) were directly measured from the frequently sampled intravenous glucose tolerance test among African-American, Hispanic, and non-Hispanic white subjects aged 40–69 years. After 5.2 years, 127 individuals had developed metabolic syndrome. In separate logistic regression models adjusting for age, sex, ethnicity, clinic, and alcohol consumption, subjects in the upper quartiles of ALT, ALK, and CRP were at significantly increased risk of incident metabolic syndrome compared with those in the lowest quartile: ALT, odds ratio 2.50 (95% CI 1.38–4.51); ALK, 2.28 (1.24–4.20); and CRP, 1.33 (1.09–1.63). Subjects in the upper quartile of the AST-to-ALT ratio were at significantly reduced metabolic syndrome risk (0.40 [0.22–0.74]). After further adjustment for waist circumference, Si, AIR, and impaired glucose tolerance, the associations of ALT and the AST-to-ALT ratio with incident metabolic syndrome remained significant (ALT, 2.12 [1.10–4.09]; the AST-to-ALT ratio, 0.48 [0.25–0.95]). These associations were not modified by ethnicity or sex, and they remained significant after exclusion of former and heavy drinkers. In conclusion, NAFLD markers ALT and the AST-to-ALT ratio predict metabolic syndrome independently of potential confounding variables, including directly measured Si and AIR.
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Nonalcoholic Fatty Liver Disease
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Self-citationUpdated definitions of healthy ranges for serum alanine aminotransferase levels
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“Metabolic syndrome, characterized by a core set of disorders, including abdominal obesity, dyslipidemia, hypertension, and hyperglycemia, has been shown to be an important predictor of type 2 diabetes (1–4) and of cardiovascular disease (1,5,6).”
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Metadata
- Authors
- Hanley, A. J. G., Williams, K., Festa, A., Wagenknecht, L. E., D’Agostino, R. B., & Haffner, S. M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-11-01
- Volume
- 54
- Issue
- 11
- Pages
- 3140-3147
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2122840090
- Cited by
- 419
- References
- 12
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- closed
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