The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes
Open accessAbstract
To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model of type 2 diabetes, were mated with either heterozygous knockout mice or two types of transgenic mice of 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone located in the ER. Systemic expression of ORP150 in Akita mice improves insulin intolerance, whereas the exclusive overexpression of ORP150 in pancreatic β-cells of Akita mice did not change their glucose tolerance. Both an insulin tolerance test and hyperinsulinemic-euglycemic clamp revealed that ORP150 enhanced glucose uptake, accompanied by suppression of oxidized protein. Furthermore, ORP150 enhanced the insulin sensitivity of myoblast cells treated with hydrogen peroxide. These data suggest that ORP150 plays an important role in insulin sensitivity and is a potential target for the treatment of diabetes.
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Citations
Cites
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
Targeted disruption of the chop gene delays endoplasmic reticulum stress-mediated diabetes
Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., & Mori, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214550 · Cited by 752
Cited by
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802
DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611
Özcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., & Hotamisligil, G. S. (2006) · Science · doi:10.1126/science.1128294 · Cited by 2,413
Metadata
- Authors
- Ozawa, K., Miyazaki, M., Matsuhisa, M., Takano, K., Nakatani, Y., Hatazaki, M., Tamatani, T., Yamagata, K., Miyagawa, J.-I., Kitao, Y., Hori, O., Yamasaki, Y., & Ogawa, S.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-03-01
- Volume
- 54
- Issue
- 3
- Pages
- 657-663
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2166742784
- Cited by
- 209
- References
- 2
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes. https://app.cochat.ai/papers/10.2337/diabetes.54.3.657
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- Ozawa, K., Miyazaki, M., Matsuhisa, M., Takano, K., Nakatani, Y., Hatazaki, M., Tamatani, T., Yamagata, K., Miyagawa, J.-I., Kitao, Y., Hori, O., Yamasaki, Y., & Ogawa, S. (2005). The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes. Diabetes. https://doi.org/10.2337/diabetes.54.3.657
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