The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of β-Cells in the Adult Pancreas
Open accessAbstract
The homeodomain transcription factor Pdx1 is essential for pancreas development. To investigate the role of Pdx1 in the adult pancreas, we employed a mouse model in which transcription of Pdx1 could be reversibly repressed by administration of doxycycline. Repression of Pdx1 in adult mice impaired expression of insulin and glucagon, leading to diabetes within 14 days. Pdx1 repression was associated with increased cell proliferation predominantly in the exocrine pancreas and upregulation of genes implicated in pancreas regeneration. Following withdrawal of doxycycline and derepression of Pdx1, normoglycemia was restored within 28 days; during this period, Pdx1+/Ins+ and Pdx+/Ins− cells were observed in association with the duct epithelia. These findings confirm that Pdx1 is required for β-cell function in the adult pancreas and indicate that in the absence of Pdx1 expression, a regenerative program is initiated with the potential for Pdx1-dependent β-cell neogenesis.
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Citations
Cites
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Parsons, J. A., Bartke, A., & Sorenson, R. L. (1995) · Endocrinology · doi:10.1210/en.136.5.2013 · Cited by 152
Cited by
Park, J. H., Stoffers, D. A., Nicholls, R. D., & Simmons, R. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33655 · Cited by 640
Benner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-620 · Cited by 302
Pancreas and beta-cell development: from the actual to the possible
Murtaugh, L. C. (2007) · Development · doi:10.1242/dev.02770 · Cited by 289
Gauthier, B. R., Wiederkehr, A., Baquié, M., Dai, C., Powers, A. C., Kerr-Conte, J., Pattou, F., MacDonald, R. J., Ferrer, J., & Wollheim, C. B. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.002 · Cited by 115
Self-citationMaintenance of β-Cell Maturity and Plasticity in the Adult Pancreas
Szabat, M., Lynn, F. C., Hoffman, B. G., Kieffer, T. J., Allan, D. W., & Johnson, J. D. (2012) · Diabetes · doi:10.2337/db11-1361 · Cited by 68
Metadata
- Authors
- Holland, A. M., Góñez, L. J., Naselli, G., MacDonald, R. J., & Harrison, L. C.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-09-01
- Volume
- 54
- Issue
- 9
- Pages
- 2586-2595
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2111533983
- Cited by
- 162
- References
- 2
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Holland, A. M., Góñez, L. J., Naselli, G., MacDonald, R. J., & Harrison, L. C. (2005). Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of β-Cells in the Adult Pancreas. Diabetes. https://doi.org/10.2337/diabetes.54.9.2586
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