The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Effects of Type 1 Diabetes on Gray Matter Density as Measured by Voxel-Based Morphometry
Abstract
The effects of type 1 diabetes and key metabolic variables on brain structure are not well understood. Sensitive methods of assessing brain structure, such as voxel-based morphometry (VBM), have not previously been used to investigate central nervous system changes in a diabetic population. Using VBM, we compared type 1 diabetic patients aged 25–40 years with disease duration of 15–25 years and minimal diabetes complications with an age-matched, nondiabetic control group. We investigated whether lower than expected gray matter densities were present, and if so, whether they were associated with glycemic control and history of severe hypoglycemic events. In comparison with control subjects, diabetic patients showed lower density of gray matter in several brain regions. Moreover, in the patient group, higher HbA1c levels and severe hypoglycemic events were associated with lower density of gray matter in brain regions responsible for language processing and memory. Our study represents the first comprehensive study of gray matter density changes in type 1 diabetes and suggests that persistent hyperglycemia and acute severe hypoglycemia have an impact on brain structure.
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Cites
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Wechsler, D. (2019) · PsycTESTS Dataset · doi:10.1037/t49755-000 · Cited by 2,327
The Diabetes Control and Complications Trial Research Group* (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-4-199602150-00001 · Cited by 160
Cited by
Cryer, P. E., Davis, S. N., & Shamoon, H. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1902 · Cited by 1,160
Adiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820
Long-term effect of diabetes and its treatment on cognitive function
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa066397 · Cited by 646
Decreased Retinal Ganglion Cell Layer Thickness in Patients with Type 1 Diabetes
van Dijk, H. W., Verbraak, F. D., Kok, P. H. B., Garvin, M. K., Sonka, M., Lee, K., DeVries, J. H., Michels, R. P. J., van Velthoven, M. E. J., Schlingemann, R. O., et al. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-5041 · Cited by 359
Assessment and monitoring of glycemic control in children and adolescents with diabetes
Rewers, M. J., Pillay, K., de Beaufort, C., Craig, M. E., Hanas, R., Acerini, C. L., & Maahs, D. M. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12190 · Cited by 316
Metadata
- Authors
- Musen, G., Lyoo, I. K., Sparks, C. R., Weinger, K., Hwang, J., Ryan, C. M., Jimerson, D. C., Hennen, J., Renshaw, P. F., & Jacobson, A. M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-02-01
- Volume
- 55
- Issue
- 2
- Pages
- 326-333
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2167415409
- Cited by
- 319
- References
- 5
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of Type 1 Diabetes on Gray Matter Density as Measured by Voxel-Based Morphometry. https://app.cochat.ai/papers/10.2337/diabetes.55.02.06.db05-0520
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- Musen, G., Lyoo, I. K., Sparks, C. R., Weinger, K., Hwang, J., Ryan, C. M., Jimerson, D. C., Hennen, J., Renshaw, P. F., & Jacobson, A. M. (2006). Effects of Type 1 Diabetes on Gray Matter Density as Measured by Voxel-Based Morphometry. Diabetes. https://doi.org/10.2337/diabetes.55.02.06.db05-0520
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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