The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes
Abstract
Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observed that acute hyperglycemia results in endothelial glycocalyx damage. To establish whether glycocalyx is associated with microvascular damage, we performed glycocalyx perturbation volume measurements in type 1 diabetic patients with microalbuminuria (DM1-MA group; n = 7), without microalbuminuria (DM1-NA group; n = 7), and in age-matched control subjects (CON; n = 7). Systemic glycocalyx volume was determined comparing intravascular distribution volume of a glycocalyx-permeable tracer (dextran 40) to that of a glycocalyx-impermeable tracer (labeled erythrocytes). Sublingual capillaries were visualized using orthogonal polarization spectral microscopy to estimate microvascular glycocalyx. Patients and control subjects were matched according to age and BMI. Glycocalyx volume decreased in a stepwise fashion from CON, DM1-NA, and finally DM1-MA subjects (1.5 ± 0.1, 0.8 ± 0.4, and 0.2 ± 0.1 l, respectively, P < 0.05). Microvascular glycocalyx in sublingual capillaries was also decreased in type 1 diabetes versus the control group (0.5 ± 0.1 vs. 0.9 ± 0.1 μm, P < 0.05). Plasma hyaluronan, a principal glycocalyx constituent, and hyaluronidase were increased in type 1 diabetes. In conclusion, type 1 diabetic patients are characterized by endothelial glycocalyx damage, the severity of which is increased in presence of microalbuminuria.
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Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
(2005) · New England Journal of Medicine · doi:10.1056/nejmoa052187 · Cited by 5,138
Cited by
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Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential
Becker, B. F., Chappell, D., Bruegger, D., Annecke, T., & Jacob, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq137 · Cited by 438
Endothelial permeability, LDL deposition, and cardiovascular risk factors—a review
Mundi, S., Massaro, M., Scoditti, E., Carluccio, M. A., van Hinsbergh, V. W. M., Iruela-Arispe, M. L., & De Caterina, R. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx226 · Cited by 367
Derangement of the endothelial glycocalyx in sepsis
Iba, T., & Levy, J. H. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14371 · Cited by 322
Lenoir, O., Jasiek, M., Hénique, C., Guyonnet, L., Hartleben, B., Bork, T., Chipont, A., Flosseau, K., Bensaada, I., Schmitt, A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1049799 · Cited by 296
Metadata
- Authors
- Nieuwdorp, M., Mooij, H. L., Kroon, J., Atasever, B., Spaan, J. A. E., Ince, C., Holleman, F., Diamant, M., Heine, R. J., Hoekstra, J. B. L., Kastelein, J. J. P., Stroes, E. S. G., & Vink, H.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-04-01
- Volume
- 55
- Issue
- 4
- Pages
- 1127-1132
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2046256807
- Cited by
- 442
- References
- 2
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes. https://app.cochat.ai/papers/10.2337/diabetes.55.04.06.db05-1619
- The paper
- Nieuwdorp, M., Mooij, H. L., Kroon, J., Atasever, B., Spaan, J. A. E., Ince, C., Holleman, F., Diamant, M., Heine, R. J., Hoekstra, J. B. L., Kastelein, J. J. P., Stroes, E. S. G., & Vink, H. (2006). Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes. Diabetes. https://doi.org/10.2337/diabetes.55.04.06.db05-1619
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