The DOI matches its Crossref record.
Treatment of Diabetic Neuropathy With γ-Linolenic Acid
Abstract
Objective— To compare the effects of placebo and GLA on the course of mild diabetic neuropathy over 1 yr. Research Design and Methods— We entered 111 patients with mild diabetic neuropathy from seven centers into a randomized, double-blind, placebo-controlled parallel study of GLA at a dose of 480 mg/day. MNCV, SNAP, CMAP, hot and cold thresholds, sensation, tendon reflexes, and muscle strength were assessed by standard tests in upper and lower limbs. Results— For all 16 parameters, the change over 1 yr in response to GLA was more favorable than the change with placebo, and for 13 parameters, the difference was statistically significant. Sex, age, and type of diabetes did not influence the result, but treatment was more effective in relatively well-controlled than in poorly-controlled diabetic patients. Conclusions— GLA had a beneficial effect on the course of diabetic neuropathy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Boulton, A. J. M., Malik, R. A., Arezzo, J. C., & Sosenko, J. M. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1458 · Cited by 913
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
Dewanjee, S., Das, S., Das, A. K., Bhattacharjee, N., Dihingia, A., Dua, T. K., Kalita, J., & Manna, P. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.034 · Cited by 300
Diabetic neuropathy and oxidative stress
Pop-Busui, R., Sima, A., & Stevens, M. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.625 · Cited by 286
Marine Cryptophytes Are Great Sources of EPA and DHA
Peltomaa, E., Johnson, M., & Taipale, S. (2017) · Marine Drugs · doi:10.3390/md16010003 · Cited by 137
Omega-6 fats for the primary and secondary prevention of cardiovascular disease
Hooper, L., Al-Khudairy, L., Abdelhamid, A. S., Rees, K., Brainard, J. S., Brown, T. J., Ajabnoor, S. M., O'Brien, A. T., Winstanley, L. E., Donaldson, D. H., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011094.pub4 · Cited by 133
Metadata
- Authors
- Keen, H., Payan, J., Allawi, J., Walker, J., Jamal, G. A., Weir, A. I., Henderson, L. M., Bissessar, E. A., Watkins, P. J., Sampson, M., Gale, E. A. M., Scarpello, J., Boddie, H. G., Hardy, K. J., Thomas, P. K., Misra, P., Halonen, J.-P., & The γ-Linolenic Acid Multicenter Trial Group
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1993-01-01
- Volume
- 16
- Issue
- 1
- Pages
- 8-15
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2095113142
- Cited by
- 220
- References
- 0
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Treatment of Diabetic Neuropathy With γ-Linolenic Acid. https://app.cochat.ai/papers/10.2337/diacare.16.1.8
- The paper
- Keen, H., Payan, J., Allawi, J., Walker, J., Jamal, G. A., Weir, A. I., Henderson, L. M., Bissessar, E. A., Watkins, P. J., Sampson, M., Gale, E. A. M., Scarpello, J., Boddie, H. G., Hardy, K. J., Thomas, P. K., Misra, P., Halonen, J.-P., & The γ-Linolenic Acid Multicenter Trial Group. (1993). Treatment of Diabetic Neuropathy With γ-Linolenic Acid. Diabetes Care. https://doi.org/10.2337/diacare.16.1.8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
