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Cited by 330Diabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and HealthDiabetes Management and Research

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Daily Walking Combined With Diet Therapy Is a Useful Means for Obese NIDDM Patients Not Only to Reduce Body Weight But Also to Improve Insulin Sensitivity

Yamanouchi, Kunio, Shinozaki, Takashi, Chikada, Kiwami, Nishikawa, Toshihiko, Ito, Katsunori, Shimizu, Shoji, Ozawa, Norihito, Suzuki, Yoichiro, Maeno, Hitoshi, Kato, Katsumi, Oshida, Yoshiharu, Sato, Yuzo·1995·Diabetes Care
DOI 10.2337/diacare.18.6.775
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Abstract

OBJECTIVE: To evaluate the effects of walking combined with diet therapy (1,000–1,600 kcal/day) on insulin sensitivity in obese non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS: Subjects were divided into two groups: 10 patients were managed by diet alone (group D), and 14 patients were placed in the diet and exercise group (group DE). Group DE was instructed to walk at least 10,000 steps/day on a flat field as monitored by pedometer (19,200 ± 2,100 steps/day), and group D was told to maintain a normal daily routine (4,500 ± 290 steps/day). A glucose clamp procedure at an insulin infusion rate of 40 mU · m−2 · min−1 was performed before and after the 6-; to 8-week training program. Mean serum insulin concentrations ranged from 720 to 790 pmol/l. RESULTS: While body weight (BW) in groups D and DE decreased significantly (P < 0.01) during the study, the amount of BW reduction in group DE was > that in group D (7.8 ± 0.8 vs. 4.2 ± 0.5 kg, P < 0.01). After training, glucose infusion rate (GIR) and metabolic clearance rate (MCR) in group D did not significantly increase; however, GIR and MCR increased significantly in group DE, from 17.21 ± 1.11 to 26.09 ± 1.11 μmol·kg−1 · min−1 (P < 0.001) and from 3.0 ± 0.3 to 5.3 ± 0.4 ml·kg−1 · min−1 (P < 0.001), respectively. The analysis of variance showed significant effects of exercise (time × exercise, P = 0.0005) for the improvement of MCR. Significant correlations were also observed between Δ MCR and average steps per day (r = 0.7257, P < 0.005) in group DE. CONCLUSIONS: Walking, which can be safely performed and easily incorporated into daily life, can be recommended as an adjunct therapy to diet treatment in obese NIDDM patients, not only for BW reduction, but also for improvement of insulin sensitivity.

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Metadata

Authors
Yamanouchi, K., Shinozaki, T., Chikada, K., Nishikawa, T., Ito, K., Shimizu, S., Ozawa, N., Suzuki, Y., Maeno, H., Kato, K., Oshida, Y., & Sato, Y.
Affiliations
  • Nagoya University (JP)
  • Aichi Medical University (JP)
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
1995-06-01
Volume
18
Issue
6
Pages
775-778
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/diacare.18.6.775
OpenAlex
W2011270818
Cited by
330
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 11
FWCI
3.95
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
walking exercise, dietary therapy, obesity, type 2 diabetes, insulin sensitivity, weight loss, glucose infusion rate, metabolic clearance rate, pedometers, daily step count, glucose clamp, insulin resistance, type 2 diabetes management, insulin secretion, glucose metabolism
MeSH terms
Adult, Blood Glucose, Body Weight, Energy Intake, Combined Modality Therapy, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diet, Diabetic, Diet, Reducing, Female, Glucose Tolerance Test, Humans, Infusions, Intravenous, Insulin, Male, Middle Aged, Obesity, Glucose Clamp Technique, Exercise, Body Mass Index, Walking

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