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The U.K. Prospective Diabetes Study. A review
Abstract
The objective of the U.K. Prospective Diabetes Study (UKPDS), initiated in 1977, was set up to determine whether improved blood glucose control in people with type 2 diabetes will prevent the complications of diabetes. The UKPDS was also designed to determine whether there are differences between conventional policy (diet therapy) and three different regimens of intensive treatment policy, based on sulfonylurea, metformin, or insulin. Interim efficacy analyses revealed that the intensive policies with sulfonylurea, insulin, and metformin were equally effective in reducing fasting plasma glucose concentrations. However, glucose and HbA1c measurements steadily increased with time, reflecting ongoing deterioration of beta-cell function. Cardiovascular disease was the major cause of complications, and the risk factors included raised LDL cholesterol concentrations, low HDL cholesterol concentrations, elevated blood pressure, elevated HbA1c concentrations, and smoking. A final study report was issued in September 1998, when the median duration of therapy was 11 years.
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“The UK prospective diabetes study showed the importance of dyslipidaemia for cardiovascular disease risk in people with T2D.59”
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Beckman, J. A., Creager, M. A., & Libby, P. (2002) · JAMA · doi:10.1001/jama.287.19.2570 · Cited by 2,765
Oral Antihyperglycemic Therapy for Type 2 Diabetes
Inzucchi, S. E. (2002) · JAMA · doi:10.1001/jama.287.3.360 · Cited by 1,065
“The need for additional therapies after several years of use was also demonstrated in metformin-treated subjects in the UKPDS, so beta cell failure also occurs in patients who are treated with this agent.(67) It is approved for use as monotherapy and in combination”
BackgroundFeinman, R. D., Pogozelski, W. K., Astrup, A., Bernstein, R. K., Fine, E. J., Westman, E. C., Accurso, A., Frassetto, L., Gower, B. A., McFarlane, S. I., et al. (2015) · Nutrition · doi:10.1016/j.nut.2014.06.011 · Cited by 912
Diabetic Retinopathy Preferred Practice Pattern®
Flaxel, C. J., Adelman, R. A., Bailey, S. T., Fawzi, A. A., Lim, J. I., Vemulakonda, G. A., & Ying, G. (2019) · Ophthalmology · doi:10.1016/j.ophtha.2019.09.025 · Cited by 777
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus
Gerber, P. A., & Rutter, G. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6755 · Cited by 654
“…peripheral tissues (notably adipose tissue, muscle, and the liver), the failure of the pancreatic beta cell to produce insulin in amounts that are sufficient to control blood glucose levels is a sine qua non for both prediabetes and full-blown type 2 diabetes mellitus (T2D) (5, 80, 168, 191, 199).”
Metadata
- Authors
- Turner, R. C.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Turner, Robert C
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1998-12-01
- Volume
- 21
- Issue
- Supplement_3
- Pages
- C35-C38
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2067958701
- Cited by
- 267
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 5 · 2012: 11
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- UK Prospective Diabetes Study, type 2 diabetes, tight glycemic control, glycemic control, sulfonylureas, metformin, insulin therapy, beta-cell function, cardiovascular complications, cardiovascular risk factors, LDL cholesterol, HDL cholesterol, blood pressure, smoking, HbA1c, dietary therapy
- MeSH terms
- Insulin Secretion, Adult, Aged, Blood Glucose, Demography, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Diet, Diabetic, Follow-Up Studies, United Kingdom, Humans, Hypertension, Hypoglycemic Agents, Insulin, Islets of Langerhans, Middle Aged, Prospective Studies
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