The DOI matches its Crossref record.
Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.
Abstract
OBJECTIVE: The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS: Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-based random sample of men aged 40-70. Of the 1,709 men enrolled in 1987-1989 (T1), 1,156 were followed up 7-10 years later (T2). Testosterone and SHBG levels at T1 were used to predict new cases of diabetes between T1 and T2. RESULTS: After controlling for potential confounders, diabetes at follow-up was predicted jointly and independently by lower baseline levels of free testosterone and SHBG. The odds ratio for future diabetes was 1.58 for a decrease of 1SD in free testosterone (4 ng/dl) and 1.89 for a 1SD decrease in SHBG (16 nmol/l), both significant at P < 0.02. CONCLUSIONS: Our prospective findings are consistent with previous, mainly cross-sectional reports, suggesting that low levels of testosterone and SHBG play some role in the development of insulin resistance and subsequent type 2 diabetes.
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“Both low testosterone [38]–[40] and sex hormone binding globulin (SHBG) [41], [42] are associated with metabolic syndrome and insulin resistance.”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [41]
In the citing paper
“Low testosterone levels have also been found to predict insulin resistance and the future development of type 2 diabetes (3-5).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [4]
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Items 601–618 of 618
Zolla, L. (2023) · Metabolites · doi:10.3390/metabo13060681
Differences of Diabetes Treatment and Care in Various Ethnic Minorities
Yuan, Y. E., & Caballero, A. E. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6_35
Kumar, S., Jain, J., & Jain, A. (2023) · Medical and Health Science Journal · doi:10.33086/mhsj.v7i01.3532
Functional Hypogonadism: Diabetes Mellitus, Obesity, Metabolic Syndrome, and Testosterone
Meirelles, R. M. D. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-31501-5_8
Testosterone Level and Risk of Diabetes: Follow-Up Study
Rezanezhad, B., Borgquist, R., & Elzanaty, S. (2023) · Medical Research Archives · doi:10.18103/mra.v11i9.4473
Issa, H. H., & Mohammad, M. K. Q. (2022) · Journal of Wasit for Science and Medicine · doi:10.31185/jwsm.213
“Some studies have debated that metabolic syndrome may suppress circulating testosterone levels or that low testosterone induces the metabolic syndrome (Laaksonen et al., 2004; Stellato et al., 2000).”
Tabassum, R., Mars, N., Parolo, P. D. B., Gerl, M. J., Klose, C. D., FinnGen, Pirinen, M., Simons, K., Widén, E., & Ripatti, S. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002830
Méndez, J. M., Rodríguez, J. C., Gil, J. G.-S. S., & Méndez, A. M. (2024) · Medicina de Familia SEMERGEN · doi:10.1016/j.semerg.2024.102338
Funktioneller Hypogonadismus: Diabetes mellitus, Adipositas, metabolisches Syndrom und Testosteron
Meirelles, R. M. D. R. (2024) · Springer eBooks · doi:10.1007/978-3-031-65245-5_8
Grigorian, A., Farzam, S., Moradmand, Z., Shahdadian, F., Hajhashemy, Z., Rouhani, P., & Saneei, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-92729-8
“For instance, male hormones such as testosterone and dihydrotestosterone have been demonstrated to be inversely associated with risk of diabetes incidents in middle-aged or older males in prospective cohort studies 49,50 .”
Tuomisto, A., Pinola, P., Pesonen, P., Franks, P. W., Martikainen, H. K., Tapanainen, J. S., Niinimäki, M. J., & Morin-Papunen, L. C. (2025) · Andrology · doi:10.1111/andr.70122 · Cited by 1
La obesidad y su relación con la infertilidad en hombres y mujeres
de Mola, J. R. L. (2009) · Clínicas obstétricas y ginecológicas de Norteamérica · doi:10.1016/s1885-9070(09)36028-x
Vincenzo, A. D., & Rossato, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00348-4
Analyse de la régulation de l'homéostasie des acides biliaires au sein des testicules
Holota, H. (2024) · theses.fr (ABES) · doi:10.70675/87a97831z9d93z48dazb8b7z8e7a929fc132
Saffati, G., Riveros, C. A., Obuekwe, O., Howell, S., Deebel, N. A., Kohn, T. P., & Muthigi, A. (2026) · International Journal of Impotence Research · doi:10.1038/s41443-026-01292-x
Frailty and Depression: A Latent Trait Analysis
Lohman, M. C. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/0arp-ry09
Evidências da associação entre testosteronas e doença periodontal no sexo masculino
Steffens, J. P. (2013) · Americanae (AECID Library)
Toxicity of Androgen Deprivation Therapy in Hormone-Sensitive Prostate Cancer
Akhtar, N. H., Diamond, E., Eiseler, N. T., & Tagawa, S. T. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2864-9_75
Metadata
- Authors
- Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B.
- Affiliations
- New England Research Institutes (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2000-04-01
- Volume
- 23
- Issue
- 4
- Pages
- 490-494
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2086247313
- Cited by
- 618
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 20 · 2017: 32 · 2016: 34 · 2015: 37 · 2014: 36 · 2013: 40 · 2012: 38
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7p01ag004673-05)
- National Institute on Aging (AG 04673)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 51345, R01DK044995, DK44995, R01DK051345)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone, sex hormone-binding globulin, type 2 diabetes, free testosterone, insulin resistance, middle-aged men, Massachusetts Male Aging Study, diabetes risk factors, older men
- MeSH terms
- Adult, Aged, Aging, Diabetes Mellitus, Type 2, Heart Diseases, Humans, Hypertension, Longitudinal Studies, Male, Massachusetts, Middle Aged, Predictive Value of Tests, Sex Hormone-Binding Globulin, Testosterone, Time Factors, Cohort Studies, Health Behavior, Racial Groups
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