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Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.

Stellato, R K, Feldman, H A, Hamdy, O, Horton, E S, McKinlay, J B·2000·Diabetes Care

DOI 10.2337/diacare.23.4.490

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Abstract

OBJECTIVE: The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS: Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-based random sample of men aged 40-70. Of the 1,709 men enrolled in 1987-1989 (T1), 1,156 were followed up 7-10 years later (T2). Testosterone and SHBG levels at T1 were used to predict new cases of diabetes between T1 and T2. RESULTS: After controlling for potential confounders, diabetes at follow-up was predicted jointly and independently by lower baseline levels of free testosterone and SHBG. The odds ratio for future diabetes was 1.58 for a decrease of 1SD in free testosterone (4 ng/dl) and 1.89 for a 1SD decrease in SHBG (16 nmol/l), both significant at P < 0.02. CONCLUSIONS: Our prospective findings are consistent with previous, mainly cross-sectional reports, suggesting that low levels of testosterone and SHBG play some role in the development of insulin resistance and subsequent type 2 diabetes.

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Authors: Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B.
Affiliations: New England Research Institutes (US)
ORCID: Stellato, R K
Feldman, H A
Hamdy, O
Horton, E S
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2000-04-01
Volume: 23
Issue: 4
Pages: 490-494
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.23.4.490
OpenAlex: W2086247313
Cited by: 618
References: 0
Citations by year: 2026: 2 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 20 · 2017: 32 · 2016: 34 · 2015: 37 · 2014: 36 · 2013: 40 · 2012: 38
FWCI: 8.23
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7p01ag004673-05)
National Institute on Aging (AG 04673)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 51345, R01DK044995, DK44995, R01DK051345)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: testosterone, sex hormone-binding globulin, type 2 diabetes, free testosterone, insulin resistance, middle-aged men, Massachusetts Male Aging Study, diabetes risk factors, older men
MeSH terms: Adult, Aged, Aging, Diabetes Mellitus, Type 2, Heart Diseases, Humans, Hypertension, Longitudinal Studies, Male, Massachusetts, Middle Aged, Predictive Value of Tests, Sex Hormone-Binding Globulin, Testosterone, Time Factors, Cohort Studies, Health Behavior, Racial Groups

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Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.

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