The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Intensive Lifestyle Changes Are Necessary to Improve Insulin Sensitivity
Abstract
OBJECTIVE—The extent to which lifestyle must be altered to improve insulin sensitivity has not been established. This study compares the effect on insulin sensitivity of current dietary and exercise recommendations with a more intensive intervention in normoglycemic insulin-resistant individuals. RESEARCH DESIGN AND METHODS—Seventy-nine normoglycemic insulin-resistant (determined by the euglycemic insulin clamp) men and women were randomized to either a control group or one of two combined dietary and exercise programs. One group (modest level) was based on current recommendations and the other on a more intensive dietary and exercise program. Insulin sensitivity was measured using a euglycemic insulin clamp, body composition was measured using dual-energy X-ray absorptiometry, and anthropometry and aerobic fitness were assessed before and after a 4-month intervention period. Four-day dietary intakes were recorded, and fasting glucose, insulin, and lipids were measured. RESULTS—Only the intensive group showed a significant improvement in insulin sensitivity (23% increase, P=0.006 vs. 9% in the modest group, P=0.23). This was associated with a significant improvement in aerobic fitness (11% increase in the intensive group, P=0.02 vs. 1% in the modest group, P=0.94) and a greater fiber intake, but no difference in reported total or saturated dietary fat. CONCLUSIONS—Current clinical dietary and exercise recommendations, even when vigorously implemented, did not significantly improve insulin sensitivity; however, a more intensive program did. Improved aerobic fitness appeared to be the major difference between the two intervention groups, although weight loss and diet composition may have also played an important role in determining insulin sensitivity.
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Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 12×
“The recent results of the Finnish Diabetes Prevention Study showed that after a mean follow-up of 3.2 years, a combined diet and exercise program reduced conversion from IGT to type 2 diabetes from 23% in the control group to 11% in the intervention group (4).”
BackgroundInfluentialPollock, M. L., Gaesser, G. A., Butcher, J. D., Despr??s, J.-P., Dishman, R. K., Franklin, B. A., & Garber, C. E. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199806000-00032 · Cited by 3,051
Ross, R., Dagnone, D., Jones, P. J. H., Smith, H., Paddags, A., Hudson, R., & Janssen, I. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-2-200007180-00008 · Cited by 1,435
Effects of weight loss on regional fat distribution and insulin sensitivity in obesity.
Goodpaster, B. H., Kelley, D. E., Wing, R. R., Meier, A., & Thaete, F. L. (1999) · Diabetes · doi:10.2337/diabetes.48.4.839 · Cited by 608
Yamanouchi, K., Shinozaki, T., Chikada, K., Nishikawa, T., Ito, K., Shimizu, S., Ozawa, N., Suzuki, Y., Maeno, H., Kato, K., et al. (1995) · Diabetes Care · doi:10.2337/diacare.18.6.775 · Cited by 330 · cited 1×
“(24) compared two groups of hospitalized obese people with diabetes, all of whom made similar dietary changes.”
BackgroundDietary treatment of the metabolic syndrome — the optimal diet
Riccardi, G., & Rivellese, A. A. (2000) · British Journal of Nutrition · doi:10.1017/s0007114500001082 · Cited by 265
Cited by
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Lin, X., Zhang, X., Guo, J., Roberts, C. K., McKenzie, S., Wu, W., Liu, S., & Song, Y. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002014 · Cited by 758
Characterizing the profile of obese patients who are metabolically healthy
Primeau, V, Coderre, L., Karelis, A. D., Brochu, M., Lavoie, M.-E., Messier, V, Sladek, R., & Rabasa-Lhoret, R. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.216 · Cited by 637
Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus
Mann, J. I., De Leeuw, I., Hermansen, K., Karamanos, B., Karlström, B., Katsilambros, N., Riccardi, G., Rivellese, A. A., Rizkalla, S., Slama, G., et al. (2004) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/s0939-4753(04)80028-0 · Cited by 527
Self-citationMeta-analysis: The Effect of Dietary Counseling for Weight Loss
Dansinger, M. L., Tatsioni, A., Wong, J. B., Chung, M., & Balk, E. M. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-1-200707030-00007 · Cited by 467
Metadata
- Authors
- McAuley, K. A., Williams, S. M., Mann, J. I., Goulding, A., Chisholm, A., Wilson, N., Story, G., McLay, R. T., Harper, M. J., & Jones, I. E.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-03-01
- Volume
- 25
- Issue
- 3
- Pages
- 445-452
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W1971638892
- Cited by
- 212
- References
- 7
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- McAuley, K. A., Williams, S. M., Mann, J. I., Goulding, A., Chisholm, A., Wilson, N., Story, G., McLay, R. T., Harper, M. J., & Jones, I. E. (2002). Intensive Lifestyle Changes Are Necessary to Improve Insulin Sensitivity. Diabetes Care. https://doi.org/10.2337/diacare.25.3.445
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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