Cited by 40Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

Fenofibrate Lowers Plasma Triglycerides and Increases LDL Particle Diameter in Subjects With Type 2 Diabetes

Vakkilainen, Juha, Steiner, George, Ansquer, Jean-Claude, Perttunen-Nio, Hëlinä, Taskinen, Marja-Riitta·2002·Diabetes Care

Abstract

Subjects with type 2 diabetes have an increased risk of coronary artery disease (CAD). The typical dyslipidemia in type 2 diabetes consists of hypertriglyceridemia, low HDL cholesterol level, and preponderance of small, dense LDL particles. Epidemiological studies have linked all these lipid abnormalities with CAD. The Diabetes Atherosclerosis Intervention Study (DAIS) has recently reported that treatment with fenofibrate results in favorable changes in the plasma lipid profile and a significant reduction in the progression of CAD in subjects with type 2 diabetes (1). We have now determined the long-term effect of fenofibrate on LDL peak particle diameter in 46 Finnish DAIS study participants with type 2 diabetes. The baseline characteristics in our DAIS subpopulation were similar to those in the whole cohort (2). Subjects were randomly assigned micronized 200 mg fenofibrate once daily ( n =25) or placebo ( n =21) for at least 3 years. Data obtained at randomization were used as the baseline data, and …

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Registry

Crossref · 10.2337/diacare.25.3.627

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  • The Diabetes Atherosclerosis Intervention Study reported a significant reduction in coronary artery disease progression in subjects with type 2 diabetes.

    “For example, the Diabetes Atherosclerosis Intervention Study (DIAS) reported a significant reduction in CAD progression in subjects with T2D.”

    From Fenofibrate and metabolic syndrome (2010) · cites this paper as [70]

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Authors
Vakkilainen, J., Steiner, G., Ansquer, J.-C., Perttunen-Nio, H., & Taskinen, M.-R.
Affiliations
  • Helsinki University Hospital (FI)
  • University Health Network (CA)
  • Laboratories Fournier, Daix, France
Venue
Diabetes Care
Published
2002-03-01
Volume
25
Issue
3
Pages
627-628
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
OpenAlex
W2086524291
Cited by
40
References
8
Citations by year
2022: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
3.53
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vlaamse regering
  • U.S. Food and Drug Administration
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
fenofibrate, type 2 diabetes, plasma triglycerides, hypertriglyceridemia, small dense LDL, dyslipidemia, coronary artery disease, lipid-lowering therapy
MeSH terms
Hypolipidemic Agents, Coronary Disease, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Lipoproteins, LDL, Cholesterol, LDL, Placebos, Fenofibrate, Triglycerides

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