Fenofibrate Lowers Plasma Triglycerides and Increases LDL Particle Diameter in Subjects With Type 2 Diabetes
Abstract
Subjects with type 2 diabetes have an increased risk of coronary artery disease (CAD). The typical dyslipidemia in type 2 diabetes consists of hypertriglyceridemia, low HDL cholesterol level, and preponderance of small, dense LDL particles. Epidemiological studies have linked all these lipid abnormalities with CAD. The Diabetes Atherosclerosis Intervention Study (DAIS) has recently reported that treatment with fenofibrate results in favorable changes in the plasma lipid profile and a significant reduction in the progression of CAD in subjects with type 2 diabetes (1). We have now determined the long-term effect of fenofibrate on LDL peak particle diameter in 46 Finnish DAIS study participants with type 2 diabetes. The baseline characteristics in our DAIS subpopulation were similar to those in the whole cohort (2). Subjects were randomly assigned micronized 200 mg fenofibrate once daily ( n =25) or placebo ( n =21) for at least 3 years. Data obtained at randomization were used as the baseline data, and …
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The Diabetes Atherosclerosis Intervention Study reported a significant reduction in coronary artery disease progression in subjects with type 2 diabetes.
“For example, the Diabetes Atherosclerosis Intervention Study (DIAS) reported a significant reduction in CAD progression in subjects with T2D.”
From Fenofibrate and metabolic syndrome (2010) · cites this paper as [70]
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- Authors
- Vakkilainen, J., Steiner, G., Ansquer, J.-C., Perttunen-Nio, H., & Taskinen, M.-R.
- Affiliations
- Helsinki University Hospital (FI)
- University Health Network (CA)
- Laboratories Fournier, Daix, France
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2002-03-01
- Volume
- 25
- Issue
- 3
- Pages
- 627-628
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2086524291
- Cited by
- 40
- References
- 8
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vlaamse regering
- U.S. Food and Drug Administration
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- fenofibrate, type 2 diabetes, plasma triglycerides, hypertriglyceridemia, small dense LDL, dyslipidemia, coronary artery disease, lipid-lowering therapy
- MeSH terms
- Hypolipidemic Agents, Coronary Disease, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Lipoproteins, LDL, Cholesterol, LDL, Placebos, Fenofibrate, Triglycerides
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