Docosahexaenoic Acid But Not Eicosapentaenoic Acid Increases LDL Particle Size in Treated Hypertensive Type 2 Diabetic Patients
Abstract
The dyslipidemia of type 2 diabetes includes the accumulation of small dense LDL particles in plasma that have an increased propensity to glycation and oxidation and may contribute to the endothelial dysfunction in type 2 diabetic patients. We recently reported that both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two major dietary long-chain n-3 fatty acids, significantly reduced triglycerides and increased HDL2 cholesterol without changing total, LDL, or HDL cholesterol in a group of type 2 diabetic subjects (1). We now report additional data …
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A consistent finding is an increase in mean LDL particle size, with a resulting shift towards those classified as large, rather than small, LDL particles.
“A consistent finding is an increase in mean LDL particle size, with a resulting shift towards those classified as large, rather than small, LDL particles [7, 45, 51–54].”
Treatment with DHA, but not EPA, increases LDL-C levels and LDL particle size.
“However, it is reported that treatment with DHA, but not EPA, increases LDL-C levels and LDL particle size [22, 54].”
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References 5 · Cited by 48
- Authors
- Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., Best, J. D., & Beilin, L. J.
- Affiliations
- The University of Western Australia (AU)
- The University of Melbourne (AU)
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2003-01-01
- Volume
- 26
- Issue
- 1
- Pages
- 253-253
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2067189708
- Cited by
- 48
- References
- 5
- Citations by year
- 2024: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (University of Western Australia) (submittedVersion)
- Funders
- Vetenskapsrådet
- Socialstyrelsen
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- docosahexaenoic acid, eicosapentaenoic acid, omega-3 fatty acids, LDL particle size, small dense LDL, type 2 diabetes, hypertension, dyslipidemia, endothelial dysfunction, HDL2, triglycerides
- MeSH terms
- Adult, Aged, Diabetic Nephropathies, Docosahexaenoic Acids, Fatty Acids, Unsaturated, Female, Humans, Hyperlipidemias, Hypertension, Renal, Cholesterol, LDL, Male, Middle Aged, Particle Size, Eicosapentaenoic Acid
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