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Frequency of Severe Hypoglycemia Requiring Emergency Treatment in Type 1 and Type 2 Diabetes

Leese, Graham P., Wang, Jixian, Broomhall, Janice, Kelly, Paul, Marsden, Andrew, Morrison, William, Frier, Brian M., Morris, Andrew D., For the DARTS/MEMO Collaboration·2003·Diabetes Care

DOI 10.2337/diacare.26.4.1176

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Abstract

OBJECTIVE—To determine the incidence, predisposing factors, and costs of emergency treatment of severe hypoglycemia in people with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS—Over a 12-month period, routinely collected datasets were analyzed in a population of 367,051 people, including 8,655 people with diabetes, to measure the incidence of severe hypoglycemia that required emergency assistance from Ninewells Hospital and Medical School (NHS) personnel including those in primary care, ambulance services, hospital accident and emergency departments, and inpatient care. Associated costs with these episodes were calculated. RESULTS—A total of 244 episodes of severe hypoglycemia were recorded in 160 patients, comprising 69 (7.1%) people with type 1 diabetes, 66 (7.3%) with type 2 diabetes treated with insulin, and 23 (0.8%) with type 2 diabetes treated with sulfonylurea tablets. Incidence rates were 11.5 and 11.8 events per 100 patient-years for type 1 and type 2 patients treated with insulin, respectively. Age, duration, and socioeconomic status were identified as risk factors for severe hypoglycemia. One in three cases were treated solely by the ambulance service with no other contact from health care professionals. The total estimated cost of emergency treatment of severe hypoglycemia was ≤£92,078 in one year. CONCLUSIONS—Hypoglycemia requiring emergency assistance from health service personnel is as common in people with type 2 diabetes treated with insulin as in people with type 1 diabetes. It is associated with considerable NHS resource use that has a significant economic and personal cost.

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Deprivation and Health in Scotland
Tunstall-Pedoe, H. (1993) · Postgraduate Medical Journal · doi:10.1136/pgmj.69.814.665-a · Cited by 1,171
Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia.
Gold, A. E., Macleod, K. M., & Frier, B. M. (1994) · Diabetes Care · doi:10.2337/diacare.17.7.697 · Cited by 810
Self-citation
Epidemiology of severe hypoglycemia in the diabetes control and complications trial
(1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)80085-z · Cited by 807
Hypoglycemia in the Diabetes Control and Complications Trial
The Diabetes Control and Complications Trial Research Group (1997) · Diabetes · doi:10.2337/diab.46.2.271 · Cited by 746
Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type II Diabetes (VA CSDM): Results of the feasibility trial
Abraira, C., Colwell, J. A., Nuttall, F. Q., Sawin, C. T., Nagel, N. J., Comstock, J. P., Emanuele, N. V., Levin, S. R., Henderson, W., Lee, H. S., et al. (1995) · Diabetes Care · doi:10.2337/diacare.18.8.1113 · Cited by 355
Microvascular and acute complications in IDDM patients: the EURODIAB IDDM Complications Study
Stephenson, J., Fuller, J., & EUROBIAB IDDM Complications Study Group (1994) · Diabetologia · doi:10.1007/bf00398055 · Cited by 345
Hypoglycemia in patients with type 2 diabetes mellitus
Miller, C. D., Phillips, L. S., Ziemer, D. C., Gallina, D. L., Cook, C. B., & El-Kebbi, I. M. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.13.1653 · Cited by 341

Flagged first, then by citations

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Items 401–500 of 550

The dangers of hypoglycaemia
Hicks, D. (2010) · Nursing and Residential Care · doi:10.12968/nrec.2010.12.1.45901 · Cited by 5
Emergency hospitalizations for severe hypoglycaemia in patients with type 2 diabetes
Cianni, G. D., Goretti, C., Onetto, F., Lencioni, C., Orsini, P. V. B., Sannino, C., Turco, A., & Pratesi, M. (2013) · Acta Diabetologica · doi:10.1007/s00592-013-0473-y · Cited by 5
Clinical and cost–effectiveness of insulin degludec: from clinical trials to clinical practice
Evans, M., & McEwan, P. C. (2015) · Journal of Comparative Effectiveness Research · doi:10.2217/cer.15.10 · Cited by 5
Development of a Microsphere-Based System to Facilitate Real-Time Insulin Monitoring
Kahanovitz, L., Şeker, E., Marks, R. S., Yarmush, M. L., Konry, T., & Russell, S. J. (2015) · Journal of Diabetes Science and Technology · doi:10.1177/1932296815625081 · Cited by 5
Abnormal Nocturnal Behavior due to Hypoglycemia in a Patient with Type 2 Diabetes
Yang, K. I., Kim, H. K., Baek, J., Kim, D.-E., & Park, H.-K. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5706 · Cited by 5
Hypoglycemia Care
Shin, U. J. (2015) · Journal of Korean Diabetes · doi:10.4093/jkd.2015.16.2.130 · Cited by 5
The Risk of Severe Hypoglycemia and Mortality in Patients With Type 2 Diabetes and Discharged With Acute Liver Injury
Yen, F., Hou, M., Pan, C., Liu, J., Hsu, C., & Hwu, C. (2022) · Diabetes Care · doi:10.2337/dc22-1349 · Cited by 5
Attenuated Sympathoadrenal Responses, but Not Severe Hypoglycemia, During Aggressive Glycemic Therapy of Early Type 2 Diabetes
Amiel, S. A., & Cryer, P. E. (2009) · Diabetes · doi:10.2337/db08-1647 · Cited by 5
Accuracy of a composite event definition for hypoglycemia
Min, J. Y., Presley, C. A., Wharton, J., Griffin, M. R., Greevy, R. A., Hung, A. M., Chipman, J., Grijalva, C. G., Hackstadt, A. J., & Roumie, C. L. (2019) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4712 · Cited by 5
Asymptomatic hypoglycaemia: identification and impact
Gomis, R., & Esmatjes, E. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.515 · Cited by 5
Severe hypoglycaemia in type 1 diabetes: impact of the renin-angiotensin system and other risk factors.
Pedersen‐Bjergaard, U. (2009) · PubMed · Cited by 5
When a unit of insulin is not a unit: Detemir dosing and insulin cost in type 2 diabetes mellitus
Johnson, C. K., & Shimshi, M. (2009) · Insulin · doi:10.1016/s1557-0843(09)80017-1 · Cited by 5
Hypoglycaemic emergencies attended by the Scottish Ambulance Service: a multiple methods investigation.
Fitzpatrick, D. (2015) · Stirling Online Research Repository (University of Stirling) · Cited by 5
Sulfonylureas and meglitinides: insights into physiology and translational clinical utility
Lebovitz, H. E., & Melander, A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch42 · Cited by 5
Response to Comment on: Holstein et al. Substantial Increase in Incidence of Severe Hypoglycemia Between 1997-2000 and 2007-2010: A German Longitudinal Population-Based Study. Diabetes Care 2012;35:972-975
Holstein, A. (2012) · Diabetes Care · doi:10.2337/dc12-1291 · Cited by 4
Hypoglycemia in blood glucose level in type 2 diabetic Japanese patients by continuous glucose monitoring
Hajime, M., Okada, Y., Mori, H., Uemura, F., Sonoda, S., Tanaka, K., Kurozumi, A., Narisawa, M., Torimoto, K., & Tanaka, Y. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0412-3 · Cited by 4
Role of the Adrenal Medulla in Hypoglycaemia-Associated Autonomic Failure—A Diabetic Perspective
Senthilkumaran, M., Koch, C., Herselman, M. F., & Bobrovskaya, L. (2024) · Metabolites · doi:10.3390/metabo14020100 · Cited by 5
Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance
Lu, X., Jin, G., Chen, W., Yu, X., & Ling, F. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01205 · Cited by 4
Hospitalization for hypoglycaemia in people with diabetes in Denmark, 1997–2017: Time trends in incidence and HbA1c and glucose‐lowering drug use before and after hypoglycaemia
Bengtsen, M. B., Knudsen, J. S., Bengtsen, M. B., Møller, N., & Thomsen, R. W. (2021) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.227 · Cited by 4
Analysis Estimating the Potential Cost Impact of Utilizing Flash Glucose Monitoring with Optional Alarms in Swedish Adults with Diabetes with Impaired Awareness of Hypoglycaemia, Using Intensive Insulin
Blissett, D. B., Attvall, S., & Hellmund, R. (2021) · Diabetes Therapy · doi:10.1007/s13300-021-01099-7 · Cited by 4
The Value of Insulin Degludec in Frail Older Adults with Type 2 Diabetes
Strain, W. D., Morgan, A. R., & Evans, M. (2021) · Diabetes Therapy · doi:10.1007/s13300-021-01162-3 · Cited by 4
Conversations and reactions around severe hypoglycemia (CRASH) global survey of people with type 1 diabetes or insulin-treated type 2 diabetes and caregivers: Findings from the French cohort
Chevalier, N., Penfornis, A., Riveline, J., Chartier, F., Mitchell, B. D., Osumili, B., Spaepen, E., Snoek, F. J., Peyrot, M. F., & Benabbad, I. (2021) · Annales d Endocrinologie · doi:10.1016/j.ando.2021.11.003 · Cited by 4
Glycemic Challenge Is Associated with the Rapid Cellular Activation of the Locus Ceruleus and Nucleus of Solitary Tract: Circumscribed Spatial Analysis of Phosphorylated MAP Kinase Immunoreactivity
Tapia, G. P., Agostinelli, L. J., Chenausky, S. D., Padilla, J. V. S., Navarro, V. I., Alagh, A., Si, G., Thompson, R. H., Balivada, S., & Khan, A. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072483 · Cited by 4
Rationale and protocol for the Assessment of Impact of Real-time Continuous Glucose Monitoring on people presenting with severe Hypoglycaemia (AIR-CGM) study
Avari, P., Ramli, R., Reddy, M., Oliver, N. S., & Fothergill, R. T. (2019) · BMC Endocrine Disorders · doi:10.1186/s12902-019-0439-3 · Cited by 4
ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN ULKUS DIABETIK PADA PASIEN DM TIPE 2 DI POLI PENYAKIT DALAM RSUD UMBU RARA MEHA WAINGAPU
Indarwati, R., Rachmawati, P. D., & Sidhu, Y. V. (2020) · Critical Medical and Surgical Nursing Journal · doi:10.20473/cmsnj.v8i2.17782 · Cited by 4
A novel telemedicine protocol improved outcomes for high-risk patients with type 1 diabetes: A 3-month quality improvement project during the COVID-19 pandemic
Zeller, W. P., DeGraff, B. R., & Zeller, W. P. (2021) · Journal of Clinical and Translational Endocrinology Case Reports · doi:10.1016/j.jecr.2021.100078 · Cited by 6
Patient and Prehospital Predictors of Hospital Admission for Patients With and Without Histories of Diabetes Treated by Paramedics for Hypoglycemia: A Health Record Review Study
Sinclair, J. E., Austin, M., Leduc, S., Dionne, R., Froats, M., Marchand, J., & Vaillancourt, C. (2022) · Prehospital Emergency Care · doi:10.1080/10903127.2022.2137863 · Cited by 4
Severe Hypoglycemia in Type 2 Diabetes: A Hospital-based Retrospective Study
Hsiao, Y.-C., & Chien, M.-N. (2006) · doi:10.6314/jimt.2006.17(2).04 · Cited by 4
Hypoglycemia
Cryer, P. E. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00034-1 · Cited by 5
Self-Monitoring of Blood Glucose: One STeP Forward?
Schramm, W. (2012) · Journal of Diabetes Science and Technology · doi:10.1177/193229681200600432 · Cited by 4
Increase in hypoglycemic admissions: California hospital discharge data.
Asuncion, M., Shaheen, M. A., Ganesan, K., Velasques, J., Teklehaimanot, S., Pan, D., & Norris, K. C. (2007) · PubMed · Cited by 3
Event and Cost Offsets of Switching 20% of the Type 1 Diabetes Population in Germany From Multiple Daily Injections to Continuous Subcutaneous Insulin Infusion
Zöllner, Y. F., Ziegler, R., Stueve, M., Krumreich, J., & Schauf, M. (2016) · Journal of Diabetes Science and Technology · doi:10.1177/1932296816633720 · Cited by 3
Hazardous factors besides infection in hypoglycemia
Su, Y., Lai, Y.-C., & Liao, C.-J. (2017) · Biomedical Reports · doi:10.3892/br.2017.872 · Cited by 3
Insulin degludec allows for better glycaemic control with a lower risk of hypoglycaemia in patients with chronic kidney disease and type 2 diabetes
de Lucas, M. D. G., Avilés, B., Rivas‐Ruiz, F., & Olalla, J. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108094 · Cited by 3
Comparing the incidence of hypoglycemia episodes in patients with type 2 diabetes and chronic kidney disease treated with insulin or glibenclamide
Aghaali, M., & Saghafi, H. (2018) · Clinical Diabetology · doi:10.5603/dk.2018.0012 · Cited by 3
Urgences métaboliques du diabète sucré
Lemoël, F., Mion, C., & Levraut, J. (2011) · EMC - Médecine d urgence · doi:10.1016/s1959-5182(11)38159-7 · Cited by 5
Review: The evolution of insulin treatment in type 1 diabetes: the advent of analogues
GALLEN, I. W. (2004) · The British Journal of Diabetes · doi:10.1177/14746514040040060301 · Cited by 3
The utility of routine laboratory testing in hypoglycaemic emergency department patients
Sinert, R. H., Su, M., Secko, M. A., & Zehtabchi, S. (2008) · Emergency Medicine Journal · doi:10.1136/emj.2008.060954 · Cited by 3
IDF-MENA Region Guidelines for Management of Hyperglycemia in Pregnancy
Masood, S. N., Shegem, N. S., Baqai, S. M., Suliman, M. T., Alromaihi, D., Sultan, M. T. H., Salih, B. T., Ram, U., Ahmad, Z., Al-Jufairi, Z. A., et al. (2021) · Journal of Diabetology · doi:10.4103/jod.jod_58_21 · Cited by 3
Coma diabeticum
Plikat, K., & Rockmann, F. (2005) · Intensivmedizin und Notfallmedizin · doi:10.1007/s00390-005-0638-1 · Cited by 3
Cost-Utility Analysis of Saxagliptin/Dapagliflozin Versus Gliclazide and Insulin Glargine: Economic Implications of the Outcomes of the CVD-Real Studies I and II
Torre, E., Bruno, G. M., Matteo, S. D., Martinotti, C., Valentino, M. C., Bottaro, L. C., & Colombo, G. L. (2020) · Health Services Insights · doi:10.1177/1178632920929982 · Cited by 3
Machine Learning Approaches for Type 2 Diabetes Prediction and Care ManagementPreprint
Lim, A., Singh, A. P., Chiam, J., Eckert, C., Kumar, V., Ahmad, M. A., & Teredesai, A. M. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2104.07820 · Cited by 3
Impact of Inhaled Insulin Therapy on Hypoglycemia
Levy, C. J., & Seaquist, E. R. (2026) · Diabetes Technology & Therapeutics · doi:10.1177/15209156251381294 · Cited by 2
How to prevent and treat pharmacological hypoglycemias
García, R. R., & Raya, P. M. (2014) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2013.12.004 · Cited by 2
Como prevenir y tratar las hipoglucemias farmacológicas
Reyes‐García, R., & Raya, P. M. (2014) · Revista Clínica Española · doi:10.1016/j.rce.2013.12.011 · Cited by 2
Risk of severe hypoglycaemia for various treatment regimens – a systematic review and meta-analysis of observational studies
Jakubczyk, M., Niewada, M., Rdzanek, E., & Czech, M. (2014) · Journal of Health Policy & Outcomes Research · doi:10.7365/jhpor.2014.2.9 · Cited by 2
Economic Burden of Severe Hypoglycemia Among Patients With Diabetes Mellitus
Ahammed, A., Aktaruzzaman, A., Gaffar, M. A. J., Afsana, F., Mir, A. S., Kabir, L., Selim, S., & Pathan, M. F. (2022) · Cureus · doi:10.7759/cureus.31889 · Cited by 2
Awareness of Hypoglycemic Episodes Among Patients With Type 2 Diabetes Mellitus in Aseer Region, Saudi Arabia: A Cross-Sectional Study in 2024
Alqahtani, F., Binghamiah, A. S. M., Al-Qahtani, A., Alqahtani, A., Alorfi, Y. A., Alqahtani, R. S., Alqahtani, M. S., & Alshahrani, A. A. (2024) · Cureus · doi:10.7759/cureus.72374 · Cited by 2
Severe Hypoglycemia in Patients with Diabetes
Yun, J. S., & Ko, S. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.4.273 · Cited by 2
Review on the use of insulin in primary care.
Chan, P. F., Lai, L. K. P., Wong, S., Chao, D. V. K., & Lau, I. T. (2013) · PubMed · Cited by 2
Hypoglycemia requiring paramedic assistance among adults in southwestern Ontario, Canada: a population-based retrospective cohort study
Liu, S., Columbus, M. P., Peddle, M. B., Mahon, J. L., & Spaic, T. (2021) · CMAJ Open · doi:10.9778/cmajo.20200184 · Cited by 2
Social vulnerability and hypoglycemia among patients with diabetes
Waitman, J. N., Caeiro, G., Gonzalez, S. A. R., Ré, D. P., DAGHERO, A. V., González, C. D., & Umpierrez, G. E. (2017) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2017.03.002 · Cited by 2
Diabetisches Koma und perioperative Diabetestherapie
Berndt, M., Klose, S., & Lehnert, H. (2014) · Springer eBooks · doi:10.1007/978-3-642-54953-3_67 · Cited by 2
Type 2 Diabetes Mellitus and Skeletal Health
Schwartz, A. V. (2015) · Springer eBooks · doi:10.1007/978-3-319-16402-1_2 · Cited by 2
Hypoglycemia in Type 2 Diabetes
Cryer, P. E. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_13 · Cited by 2
Hypoglycemia in Type 1 Diabetes
Amiel, S. A. (2007) · CRC Press eBooks · doi:10.3109/9781420016512-3 · Cited by 2
Hypoglycemia in Type 2 Diabetes
Cryer, P. (2007) · CRC Press eBooks · doi:10.3109/9780849379581-17 · Cited by 2
Diabetes and driving. Performance, decision making and legal aspects
Stork, A. (2006) · Utrecht University Repository (Utrecht University) · Cited by 2
Automated optimal glycaemic control using a physiology based pharmacokinetic, pharmacodynamic model
Schaller, S., Schuppert, A., & Mitsos, A. (2015) · RWTH Publications (RWTH Aachen) · Cited by 2
Hypoglykämie trotz Hyperglykämie
Erdös, G., Lobmann, R., Wolcke, B. B., & Werner, C. D. (2005) · Der Anaesthesist · doi:10.1007/s00101-005-0825-2 · Cited by 2
Comment on Duran et al. Introduction of IADPSG Criteria for the Screening and Diagnosis of Gestational Diabetes Mellitus Results in Improved Pregnancy Outcomes at a Lower Cost in a Large Cohort of Pregnant Women: The St. Carlos Gestational Diabetes Study. Diabetes Care 2014;37:2442–2450
Addison, B., & Belalcazar, L. M. (2015) · Diabetes Care · doi:10.2337/dc14-2839 · Cited by 2
Glycemic Emergencies
Hoxhaj, R., & WEBSTER, S. C. M. (2026) · Medical Clinics of North America · doi:10.1016/j.mcna.2025.11.014 · Cited by 1
Diabetisches Koma und perioperative Diabetestherapie
Klose, S., & Lehnert, H. (2004) · Springer eBooks · doi:10.1007/978-3-662-06654-6_51 · Cited by 1
Modification in redox status of diabetes mellitus type 1 patients after insulin transition
del Valle, L. G., Milian, L. D. L. C., Toledo, A., Avila, J., Tápanes, R. D., Llera, I., Otero, M. A., & Martı́nez-Sánchez, G. (2011) · Biomedicine & Preventive Nutrition · doi:10.1016/j.bionut.2010.09.005 · Cited by 1
Comparison of diabetes‐associated secondary healthcare utilization between alternative oral antihyperglycaemic dual therapy combinations with metformin in patients with type 2 diabetes: an observational cohort study
Strongman, H., D’Oca, K., Langerman, H., & Das, R. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12458 · Cited by 1
Non-Insulin Agents for Diabetes
Sreemantula, G., & Shankarnarayan, S. H. (2012) · doi:10.1007/978-1-908517-81-4_4 · Cited by 1
Understanding the use of emergency department and urgent care services by diabetic patients of a Family Medicine Health Team: a retrospective observational study
Ward, M. (2016) · Primary Health Care Research & Development · doi:10.1017/s1463423616000396 · Cited by 1
Diabetes-Old Therapies Revisited
Guimarães, J. (2016) · Endocrinology&Metabolism International Journal · doi:10.15406/emij.2016.03.00056 · Cited by 1
Inhaled Glucagon
Heba, S. F., Parveen, U., Khanum, S. S. A., Gulnaaz, M., Tabassum, M., & Safiyya, S. B. (2021) · Journal of Diabetology · doi:10.4103/jod.jod_26_20 · Cited by 1
Out-of-Hospital Management of Diabetic Emergencies in Germany: Structural and Process Quality
Holstein, D. J. F., Holstein, J. D., Fischer, D., Mende, M., Frier, B. M., & Holstein, A. (2021) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1523-7562 · Cited by 1
Self-citation
Incidence and Costs of Hypoglycemia among Type II Diabetes Mellitus Patients in Turkey
Fidan, C., Salgür, F., Kul, Ö. E., Bozkuş, Y., Eminsoy, G., Sözen, F., Kut, A., & Öksüz, E. (2021) · Journal of Biomedical Research & Environmental Sciences · doi:10.37871/jbres1300 · Cited by 1
Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort
Lin, Y. K., Black, J. E., Harris, S. B., Ryan, B. L., Zou, G., & Ratzki‐Leewing, A. A. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112230 · Cited by 1
Hypoglycemia in Diabetes Mellitus
Alsahli, M., & Gerich, J. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-09841-8_19 · Cited by 1
Diabetes Interactive Diary: A Mobile Phone-Based Telemedicine System for Carbohydrate Counting and Bolus Calculator
Vespasiani, G., & Rossi, M. C. (2014) · Frontiers in diabetes · doi:10.1159/000363519 · Cited by 1
Dental Stem Cell Differentiation Toward Endodermal Cell Lineages: Approaches to Control Hepatocytes and Beta Cell Transformation
Gnanasegaran, N., Govindasamy, V., Nathan, P., Musa, S., & Kasim, N. H. A. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-28947-2_12 · Cited by 1
Hypoglycemia
Cryer, P. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00034-4 · Cited by 1
STUDY ON AWARENESS OF SYMPTOMS OF HYPOGLYCAEMIA & EARLY MANAGEMENT AMONG PATIENTS WITH DIABETES AND THEIR CAREGIVERS
Pai, S. A., & George, P. (2019) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2019/281 · Cited by 1
Self-Monitoring of Blood Glucose and Hypoglycemia-Related Hospitalization in a Population-Based Cohort of Canadian Patients With Type 1 or Type 2 Diabetes
Buxton, K., Lix, L. M., Champagne, A., Evans, C. D., Shevchuk, Y. M., Teare, G. F., Mansell, K. D., & Blackburn, D. F. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2019.10.007 · Cited by 1
Fasting insulin levels correlate with the frequency of hypoglycemic events in people with type 2 diabetes on treatment with sulfonylureas: A pilot study
Kotsa, K., Kolokas, K., Koufakis, T., Avramidis, I., Gerou, S., Chatzidimitriou, M., & Kazakos, K. (2020) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_80_19 · Cited by 1
Feasibility and Efficiency of a Novel Bolus Calculator (IF-DIABETE) for Patients With Type 1 Diabetes: A Nonrandomized Single-Arm Pilot Study
Rouf, S., Rbiai, N., Baibai, K., Berrich, J., Bouchentouf, T., Rahmoun, M. N., Abda, N., & Latrech, H. (2021) · Cureus · doi:10.7759/cureus.12646 · Cited by 1
Hypoglycaemia in the over 75s: Understanding the predisposing factors in type 2 diabetes (T2DM)
Heald, A. H., Anderson, S. G., Cholakova, V., Narajos, M., Khan, A. R., Donnahey, G., & Livingston, M. A. (2017) · International Journal of Clinical Practice · doi:10.1111/ijcp.12932 · Cited by 1
Hypoglycemia caused by Insulin
Liatis, S., & Katsilambros, N. L. (2011) · Wiley eBooks · doi:10.1002/9781119971825.ch4 · Cited by 1
Insulin, glucagon, and hypoglycemic drugs
Krans, H. M. J. (2003) · Side effects of drugs annual · doi:10.1016/s0378-6080(03)80049-1 · Cited by 1
Schwerpunkt: Endokrine und metabolische Krisen
Reschke, K., Lehnert, H., & Magdeburg, O.-V.-G.-U. (2003) · Cited by 1
Hypoglycemia
Sandoval, D. A., Lamos, E. M., Younk, L. M., Hedrington, M. S., & Davis, S. N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.03833-2 · Cited by 1
Associations between different triglyceride glucose index-related obesity indices and eating disorders: results from NHANES 2005–2018Preprint
He, X., Du, Y., Song, K., & Ren, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-5317726/v1 · Cited by 1
Inzidenz und Risikofaktoren für schwere Hypoglykämien bei behandelten Typ-2-Diabetespatienten
Jecht, M. (2014) · Der Diabetologe · doi:10.1007/s11428-014-1283-8
Hypoglycemia and other complications of insulin therapy
Amiel, S. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch53
Relationship Between Age and Diabetic Treatment Type on the Frequency of Hyperglycemic Episodes Monitored by Continuous Glucose Monitoring
Boby, G., Zachariah, P., Parveen, Z., Patel, P., Schoeck, M., Mazulis, A., Perlmuter, L. C., & Sant, P. (2011) · InTech eBooks · doi:10.5772/22188
Equipement op de huisartsenpost voor behandeling van diabetespatiënten
Holtrop, R. (2008) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-6312-4_3
Diabetic and environmental emergencies
(2014) · Wiley eBooks · doi:10.1002/9781118655641.ch16
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
Bragd, J. (2011) · Figshare
Factores de riesgo de hipoglicemia severa en pacientes diabéticos con atención de emergencia en el Hospital del IESS-Milagro.
Ponce, M., & Stalin, L. (2014) · Americanae (AECID Library)
Insulin und Hypoglykämie
Frank, M. (2013) · Der Diabetologe · doi:10.1007/s11428-012-0913-2
Mechanisms of hypoglycaemia related sudden cardiac death in type 2 diabetes mellitus
Chow, E. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
CLINICAL ASPECTS ON GLUCOSE-LOWERING THERAPIES IN TYPE 2 DIABETES
Nybäck‐Nakell, Å. (2012) · Figshare
Comment on: Holstein et al. Substantial Increase in Incidence of Severe Hypoglycemia Between 1997–2000 and 2007–2010: A German Longitudinal Population-Based Study. Diabetes Care 2012;35:972–975
Kerner, W., & Völzke, H. (2012) · Diabetes Care · doi:10.2337/dc12-0851
How can we avoid the danger of hypoglycemia, one of the most serious complications of therapy of type 2 diabetes mellitus? The role of DPP-4 inhibitors
Pavlova, M. G., & Zilov, A. V. (2011) · Problems of Endocrinology · doi:10.14341/probl201157348-52
The ups and downs of blood sugar
Morris, D. (2015) · Independent Nurse · doi:10.12968/indn.2015.6.29
Le diabète de type 2 au stade de l’insuline : Quelle place pour les inhibiteurs de la DPP-4 ?
Halimi, S., Charbonnel, B. H., Monguillon, P., & Dejager, S. (2015) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(15)30011-0

Authors: Leese, G. P., Wang, J., Broomhall, J., Kelly, P., Marsden, A., Morrison, W., Frier, B. M., Morris, A. D., & For the DARTS/MEMO Collaboration
Affiliations: Ninewells Hospital (GB)
Scottish Ambulance Service, Tayside Division, Dundee, U.K.
Edinburgh Royal Infirmary (GB)
ORCID: Leese, Graham P.
Wang, Jixian
Morrison, William
Frier, Brian M.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2003-04-01
Volume: 26
Issue: 4
Pages: 1176-1180
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.26.4.1176
OpenAlex: W2107648636
Cited by: 559
References: 25
Citations by year: 2026: 3 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 18 · 2020: 21 · 2019: 25 · 2018: 25 · 2017: 35 · 2016: 43 · 2015: 60 · 2014: 38 · 2013: 35 · 2012: 37
FWCI: 10.97
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Patient Safety and Medication Errors
Keywords: severe hypoglycemia, type 1 diabetes, type 2 diabetes, insulin therapy, emergency treatment, ambulance services, incidence, risk factors, socioeconomic status, health care costs, NHS resource use
MeSH terms: Adult, Aged, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Emergencies, Glycated Hemoglobin, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Middle Aged, Scotland, Body Mass Index, Incidence

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Frequency of Severe Hypoglycemia Requiring Emergency Treatment in Type 1 and Type 2 Diabetes

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