The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Hyperglycemia: Intensive Insulin Infusion In Infarction (HI-5) Study
Abstract
OBJECTIVE—There is conflicting evidence regarding the benefit of intravenous insulin therapy on mortality following acute myocardial infarction (AMI). The goal of the current study was to determine whether improved glycemic control, achieved through an insulin/dextrose infusion with a variable rate of insulin, reduces mortality among hyperglycemic patients with AMI. RESEARCH DESIGN AND METHODS—Subjects suffering AMI with either known diabetes or without diabetes but blood glucose level (BGL) ≥7.8 mmol/l were randomized to receive insulin/dextrose infusion therapy for at least 24 h to maintain a BGL <10 mmol/l or conventional therapy. RESULTS—A total of 240 subjects were recruited. Insulin/dextrose infusion did not reduce mortality at the inpatient stage (4.8 vs. conventional 3.5%, P = 0.75), 3 months (7.1 vs 4.4%, P = 0.42), or 6 months (7.9 vs. 6.1%, P = 0.62). There was, however, a lower incidence of cardiac failure (12.7 vs. 22.8%, P = 0.04) and reinfarction within 3 months (2.4 vs. 6.1%, P = 0.05). When analyzed by mean BGL achieved during the first 24 h, mortality was lower among subjects with a mean BGL ≤8 mmol/l, compared with subjects with a mean BGL >8 mmol/l (2 vs. 11% at 6 months, P = 0.02). CONCLUSIONS—We did not find a reduction in mortality among patients who received insulin/dextrose infusion therapy. However, it remains possible that tight glycemic control with insulin therapy following AMI improves outcomes.
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Cites
Capes, S. E., Hunt, D., Malmberg, K., & Gerstein, H. C. (2000) · The Lancet · doi:10.1016/s0140-6736(99)08415-9 · Cited by 2,187
Cited by
Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz486 · Cited by 4,763
Standards of Medical Care in Diabetes—2009
American Diabetes Association (2009) · Diabetes Care · doi:10.2337/dc09-s013 · Cited by 2,167
Moghissi, E. S., Korytkowski, M. T., DiNardo, M., Einhorn, D., Hellman, R., Hirsch, I. B., Inzucchi, S. E., Ismail-Beigi, F., Kirkman, M. S., & Umpierrez, G. E. (2009) · Diabetes Care · doi:10.2337/dc09-9029 · Cited by 1,444
Standards of Medical Care in Diabetes—2008
American Diabetes Association (2008) · Diabetes Care · doi:10.2337/dc08-s012 · Cited by 1,377
Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis
Falciglia, M., Freyberg, R. W., Almenoff, P. L., D’Alessio, D. A., & Render, M. L. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b083f7 · Cited by 576
Management of Hyperglycemia in the Hospital Setting
Inzucchi, S. E. (2006) · New England Journal of Medicine · doi:10.1056/nejmcp060094 · Cited by 391
Kosiborod, M., Inzucchi, S. E., Krumholz, H. M., Xiao, L., Jones, P. G., Fiske, S., Masoudi, F. A., Marso, S. P., & Spertus, J. A. (2008) · Circulation · doi:10.1161/circulationaha.107.740498 · Cited by 385
Gerbaud, E., Darier, R., Montaudon, M., Beauvieux, M.-C., Coffin-Boutreux, C., Coste, P., Douard, H., Ouattara, A., & Catargi, B. (2019) · Diabetes Care · doi:10.2337/dc18-2047 · Cited by 138
Caturano, A., Galiero, R., Pafundi, P. C., Cesaro, A., Vetrano, E., Palmiero, G., Rinaldi, L., Salvatore, T., Marfella, R., Sardu, C., et al. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108959 · Cited by 73
Zhao, Y.-T., Weng, C.-L., Chen, M.-L., Li, K.-B., Ge, Y.-G., Lin, X.-M., Zhao, W.-S., Chen, J., Zhang, L., Yin, J.-X., et al. (2010) · Heart · doi:10.1136/hrt.2010.194563 · Cited by 62
Bellis, A., Mauro, C., Barbato, E., Ceriello, A., Cittadini, A., & Morisco, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020775 · Cited by 61
Mellbin, L. G., Malmberg, K., Rydén, L., Wedel, H., Vestberg, D., & Lind, M. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs384 · Cited by 57
Hyperglycemia in Acute Coronary Syndromes
Kosiborod, M. (2018) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.11.002 · Cited by 37
Management of acute coronary syndromes
Tardif, J.-C., L'Allier, P. L., & Fitchett, D. H. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.029 · Cited by 10
Metadata
- Authors
- Cheung, N. W., Wong, V. W., & McLean, M.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2006-04-01
- Volume
- 29
- Issue
- 4
- Pages
- 765-770
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2119745885
- Cited by
- 335
- References
- 1
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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