Cited by 267Heart Rate Variability and Autonomic ControlDiabetes Management and ResearchCardiovascular Syncope and Autonomic Disorders

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Autonomic Neural Dysfunction in Recently Diagnosed Diabetic Subjects

Pfeifer, Michael A, Weinberg, Clare R, Cook, Daniel L, Reenan, Andrew, Halter, Jeffrey B, Ensinck, John W, Porte, Daniel·1984·Diabetes Care

DOI 10.2337/diacare.7.5.447

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Abstract

Because onset of autonomic neural dysfunction in the diabetic syndrome has not been well established, sensitive and quantitative measures of autonomic nervous system (ANS) function were made in 19 non-insulin-dependent (NIDD) and 14 insulin-dependent (IDD) recent-onset diabetic subjects. The known duration of diabetes mellitus in the NIDD subjects was ≤ 12 mo. The duration in the IDD subjects was ≤ 24 mo. RR-variation during beta adrenergic blockade (an index of an ANS reflex involving the cardiac parasympathetic nervous system [PNS] pathway) was smaller than that of control subjects in both NIDD (P < 0.001) and IDD subjects (P < 0.01). This PNS abnormality was not likely to be due to volume depletion since acute volume depletion induced by furosemide in six normal subjects (1608 ± 105 ml, mean ± SEM) did not change RR-variation. Dark-adapted pupil size after topical PNS blockade (an index of iris sympathetic nervous system [SNS] activity) was also smaller in both groups of diabetic subjects (NIDD, P < 0.01; IDD, P < 0.05). Pupillary latency time (an index of an ANS reflex involving iris PNS pathway) was prolonged in the NIDD subjects (P < 0.005) but was not significantly altered in the IDD subjects. Thus, it would appear that the ANS is impaired soon after the diagnosis of diabetes mellitus. We hypothesize that early impairment of the ANS is common in IDD and NIDD subjects. This finding is consistent with the hypothesis that abnormal carbohydrate metabolism is an important factor in the etiology of diabetic autonomic neuropathy.

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Hoeldtke, R. D., Bryner, K. D., Hobbs, G. R., Horvath, G. G., Riggs, J. E., Christie, I., Ganser, G. H., Marcovina, S. M., & Lernmark, Å. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6830 · Cited by 28
Diabetic autonomic neuropathy—Part II
Schumer, M., Crain, G. M., & Pfeifer, M. A. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90407-x · Cited by 24
Self-citation
Diabetic autonomic neuropathy—part I
Schumer, M., Burton, G. V., Burton, C., Crum, D., & Pfeifer, M. A. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90406-8 · Cited by 23
Self-citation
Cardiovascular Function in Patients with Insulin‐Dependent Diabetes Mellitus
Rajan, S., & Gokhale, S. M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03018.x · Cited by 23
Pupillary Size in Children and Adolescents with Type 1 Diabetes
Clarke, C. F., Piesowicz, A. T., & Spathis, G. S. (1989) · Diabetic Medicine · doi:10.1111/j.1464-5491.1989.tb01278.x · Cited by 23
The Significance of Impaired Pancreatic Polypeptide and Epinephrine Responses to Hypoglycemia in Patients with Insulin-Dependent Diabetes Mellitus*
Kennedy, F. P., Bolli, G. B., Go, V. L. W., Cryer, P. E., & Gerich, J. E. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-3-602 · Cited by 23
Evolving Therapeutic Options for Type 2 Diabetes Mellitus: An Overview
Guthrie, R. M. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.11.2614 · Cited by 20
Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: The CARVAS study.
Sardu, C., Paolisso, P., Santamaria, M., Sacra, C., Pieretti, G., Rizzo, M. R., Barbieri, M., Scisciola, L., Nicoletti, G., Paolisso, G., et al. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.04.015 · Cited by 19
Urinary albumin excretion rate is independently related to autonomic neuropathy in type 2 diabetes mellitus
Wirta, O., Pasternack, A. I., Mustonen, J. T., Laippala, P. J., & Reinikainen, P. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00499.x · Cited by 21
Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus
Schlager, O., Hammer, A., Willfort‐Ehringer, A., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2502-8 · Cited by 20
“autonomic neuropathy potentially occurs at an early stage in individuals with type 1 diabetes [32].”
Background
Blood Pressure Variability in Patients with Diabetes Mellitus
Mokhtar, R. H., Ayob, A., & Noor, N. M. (2010) · Asian Cardiovascular and Thoracic Annals · doi:10.1177/0218492310375723 · Cited by 20
Noradrenaline depletion in patients with coronary artery disease before and after percutaneous transluminal coronary angioplasty with iodine-123 metaiodobenzylguanidine and single-photon emission tomography
Guertner, C., Klepzig, H., Maul, F. D., et al. (1993) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00180908 · Cited by 20
Occurrence of late specific complications in type II (non-insulin-dependent) diabetes mellitus
Wirta, O., Pasternack, A. I., Oksa, H. H., Mustonen, J. T., Koivula, T. A., Helin, H. J., & Lähde, Y. (1995) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(94)00034-l · Cited by 19
THE EFFECTS OF LONG TERM GLICLAZIDE ADMINISTRATION ON INSULIN SECRETION AND INSULIN SENSITIVITY
MA, A., Kamp, M. C., Bird, D., et al. (1989) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1989.tb01674.x · Cited by 20
Sudomotor dysfunction in diabetic peripheral neuropathy (DPN) and its testing modalities: A literature review
Akbar, M., Wandy, A., Soraya, G. V., Goysal, Y., Lotisna, M., & Basri, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18184 · Cited by 24
“Subclinical diabetic autonomic neuropathy (DAN) commonly occurs within a year or two of T2DM and T1DM diagnosis, respectively [21].”
Background
Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus
Cesana, F., Giannattasio, C., Nava, S., Soriano, F. S., Brambilla, G., Baroni, M., Meani, P., Varrenti, M., Paleari, F., Gamba, P., et al. (2013) · Blood Pressure · doi:10.3109/08037051.2013.791413 · Cited by 18
Cardiovascular risk and heart rate variability in young adults with type 2 diabetes and arterial stiffness: The SEARCH for Diabetes in Youth Study
SHAH, A. S., Jaiswal, M., Dabelea, D., Divers, J., Isom, S. P., Liese, A. D., Lawrence, J. M., Kim, G. E., & Urbina, E. M. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107676 · Cited by 19
Recognition and Management of Diabetic Neuropathy
Unger, J., & Cole, B. E. (2007) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2007.07.003 · Cited by 17
Relationship between age and autonomic neuropathy in diabetes mellitus
Kuroda, N., Taniguchi, H., Baba, S., et al. (1990) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(90)90008-h · Cited by 18
Assessing heart rate variability in type 1 diabetes mellitus—Psychosocial stress a possible confounder
Kristiansen, E., Wanby, P., Åkesson, K., Blomstrand, P., Brudin, L. H., & Thegerström, J. (2020) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12760 · Cited by 17
“Reduced HRV has been reported in children and adolescents with T1DM with very short duration (<1–2 years) in a few older studies (Pfeifer et al., 1984; Wawryk, Bates, & Couper, 1997).”
Background
Baroreflex function in streptozotocin (STZ) induced diabetic rats
Patel, K. P., & Zhang, P. L. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(94)01011-n · Cited by 17
Risk for Cardiovascular Autonomic Neuropathy Is Associated with the HLA-DR3/4 Phenotype in Type I Diabetes Mellitus
Barzilay, J. I., Warram, J. H., Rand, L. I., Pfeifer, M. A., & Królewski, A. S. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-7-544 · Cited by 17
“For example, based on the heart-rate response to deep breathing or to the change from the supine to the upright position, between 20% and 40% of patients with type I diabetes have impaired function, often as early as the first year of diabetes (1-8).”
BackgroundSelf-citation
New mechanisms for sulfonylurea control of insulin secretion
Satin, L. S. (1996) · Endocrine · doi:10.1007/bf02738684 · Cited by 17
“Oral antidiabetic sulfonylureas are used in the treatment of NIDDM, as these drugs lower plasma glucose levels (Pfeifer et al., 1984).”
Background
Treatment of Diabetic Cardiovascular Autonomic, Peripheral and Painful Neuropathy. Focus on the Treatment of Cardiovascular Autonomic Neuropathy with ACE Inhibitors
Didangelos, T., & Veves, A. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190521101342 · Cited by 17
Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study
Kakutani‐Hatayama, M., Kadoya, M., Morimoto, A., Miyoshi, A., Kosaka‐Hamamoto, K., Kusunoki, Y., Shoji, T., & Koyama, H. (2020) · Metabolism Open · doi:10.1016/j.metop.2020.100033 · Cited by 16
Autonomic dysfunction and risk of severe hypoglycemia among individuals with type 2 diabetes
Kazé, A. D., Yuyun, M. F., Ahima, R. S., Rickels, M. R., & Echouffo-Tcheugui, J. B. (2022) · JCI Insight · doi:10.1172/jci.insight.156334 · Cited by 15
“Lower HRV is an early marker of CAN in the course of diabetes mellitus (32).”
A cross-sectional assessment to detect type 2 diabetes with endothelial and autonomic nervous system markers using a novel system
Lewis, J. E., Lantigua, L. A., Atlas, S. E., Lopez, J., Mendez, A. J., Goldberg, S., Medici, S., Konefal, J., Woolger, J. M., Tiozzo, E., et al. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-014-0118-x · Cited by 16
“Cardiovascular autonomic neuropathy (CAN), a form of DAN, is an early and frequent complication of type 2 diabetes mellitus that may occur within one year of diagnosis in up to 20% of patients with diabetes [8,12,13].”
Background
Diabetic Peripheral and Autonomic Neuropathy
Feldman, E. L., Stevens, M. J., & Russell, J. W. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-310-1_24 · Cited by 16
Ocular autonomic function in progressive autonomic failure
Clark, C. V., & Ewing, D. J. (1988) · Documenta Ophthalmologica · doi:10.1007/bf00157061 · Cited by 15
“This is supported by the results of a recent study which showed impairment of iris sympathetic nerve function in diabetic subjects with no other evidence of autonomic neuropathy [26].”
Result
Screening for Non-Insulin-Dependent Diabetes Mellitus (NIDDM): How Often Should it Be Performed?
Davies, M. J., & DAY, J. L. (1994) · Journal of Medical Screening · doi:10.1177/096914139400100202 · Cited by 15
Insulin secretion in noninsulin-dependent Diabetes Mellitus
Broadstone, V. L., Ward, W. K., Beard, J., Best, J. D., Halter, J. B., Judzewitsch, R., Porte, D., & Pfeifer, R. (1986) · Springer eBooks · doi:10.1007/978-94-009-4301-8_6 · Cited by 15
Self-citation
Heart Rate Variability Applications in Medical Specialties: A Narrative Review
Addleman, J. S., Lackey, N. S., Tobin, M. A., Lara, G. A., Sinha, S., Morse, R. M., HAJDUCZOK, A. G., Gharbo, R. S., & Gevirtz, R. (2025) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-025-09708-y · Cited by 18
“The evidence for this association is strong enough that the American Diabetes Association recommended that autonomic testing including HRV be performed for all patients with T2D at the time of diagnosis and 5 years after diagnosis in individuals T1D for early screening and risk stratification of CAN (Boulton et al., 2…”
Influential
Estimation of the cut-off value in cardiovascular autonomic nervous function tests: Not-age-related criteria or the age-related 5th percentile
Straub, R. H., Lang, B., Palitzsch, K.-D., et al. (1997) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(95)00126-3 · Cited by 14
Autonomic Neuropathy in Diabetes Mellitus and Obesity: An Update
Katsilambros, N. L., Boulton, A. J. M., Tentolouris, N., Kokkinos, A. D., & Liatis, S. (2011) · Experimental Diabetes Research · doi:10.1155/2011/607309 · Cited by 13
Detection of the pupil constriction latency
Bos, J. E. (1991) · Medical & Biological Engineering & Computing · doi:10.1007/bf02442326 · Cited by 13
Cardiovascular responses to tilting in healthy and diabetic subjects
Navarro, X., Kennedy, W. R., & Ferrer, M. T. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90213-q · Cited by 13
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Goit, R. K., Khadka, R., Sharma, S. K., Limbu, N., & Paudel, B. H. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.03.026 · Cited by 12
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Background
Independent predictors of cardiac parasympathetic dysfunction in type 2 diabetes mellitus.
Subbalakshmi, N. K., Adhikari, P. M., Aravindakshan, R., et al. (2008) · PubMed · Cited by 12
A system approach to pharmacodynamics II: Glyburide pharmacodynamics and estimation of optimal drug delivery
Gillespie, W. R., Veng‐Pedersen, P., Antal, E. J., & Phillips, J. P. (1988) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600770109 · Cited by 12
Cardiac autonomic neuropathy (CAN) in type-1 diabetes mellitus patients and its association with the duration of disease and glycemic control.
Khoharo, H. K., Ansari, S., Shaikh, I., & Qureshi, F. (2009) · PubMed · Cited by 11
Is erectile dysfunction a sentinel symptom for cardiovascular autonomic neuropathy in patients with type 2 diabetes?
Debono, M., Cachia, E., Cassar, A., et al. (2008) · Andrologia · doi:10.1111/j.1439-0272.2008.00799.x · Cited by 11
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Background
Relative nocturnal hypertension in children with insulin‐dependent diabetes mellitus
Madácsy, L., Yasar, A., Tulassay, T., et al. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb18132.x · Cited by 11
Peri-procedural variables and outcomes of long-period hemodynamic instability after carotid artery angioplasty and stenting
Li, B., Fan, W., Yang, Y., et al. (2022) · Vascular · doi:10.1177/17085381221091369 · Cited by 10
“The consequent stretching force exerted on the CSBs after angioplasty has been identi ﬁ ed as the most signi ﬁ cant risk factor for HI. 35,36 Thus, we postulated that aggressive and repeated balloon dilation would create a dramatic radial or linear force on the stretch receptors, thereby inducing inhibition of the sym…”
ResultInfluential
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Neil, H. A. W., & Smith, S. A. (1989) · Neuro-Ophthalmology · doi:10.3109/01658108908997360 · Cited by 10
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Adebayo, R. A., Ikwu, A. N., Balogun, M. O., Akintomide, A. O., Mene-Afejuku, T. O., Adeyeye, V. O., Bamikole, O. J., Bisiriyu, L. A., Ajayi, O. E., Ogunyemi, S. A., et al. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s68408 · Cited by 10
Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study
Deepak, A., Deepak, N., Nallulwar, S. C., & Khode, V. (2013) · National Journal of Physiology Pharmacy and Pharmacology · doi:10.5455/njppp.2014.4.080720131 · Cited by 10
“(CADN) is the most clinically important and wellstudied form of DAN.[3] An important prerequisite for therapeutic intervention to CADN is to”
Background
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Hoeldtke, R. D., Bryner, K. D., Komanduri, P., Christie, I., Ganser, G. H., & Hobbs, G. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6362 · Cited by 10
Neuropsychological Sequelae of Chronic Medical Disorders
Berg, R. A., & Linton, J. C. (1989) · Critical issues in neuropsychology · doi:10.1007/978-1-4899-6807-4_6 · Cited by 10
Excessive daytime napping independently associated with decreased insulin sensitivity in cross-sectional study – Hyogo Sleep Cardio-Autonomic Atherosclerosis cohort study
Kakutani‐Hatayama, M., Kadoya, M., Morimoto, A., Miyoshi, A., Kosaka‐Hamamoto, K., Kanzaki, A., Konishi, K., Kusunoki, Y., Syoji, T., & Koyama, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1211705 · Cited by 9
Non-Dipping and Cardiometabolic Profile: A Study on Normotensive Overweight Middle-Aged Men
Albert, B. B., de Bock, M. I., Derraik, J. G. B., Brennan, C. M., Biggs, J. B., Hofman, P. L., & Cutfield, W. S. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2016.04.012 · Cited by 9
Assessment of cardiac autonomic neuropathy in long standing type 2 diabetic women
Refaie, W. (2013) · The Egyptian Heart Journal · doi:10.1016/j.ehj.2013.06.002 · Cited by 9
Diabetic Autonomic Neuropathy
Parish, R. C. (1999) · Journal of Pharmacy Practice · doi:10.1177/089719009901200207 · Cited by 9
Diabetic Neuropathies
Bird, S. J., & Brown, M. J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6567-6_31 · Cited by 10
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Galdino, G. A. M., Silva, L. E. V., Moura-Tonello, S. C. G., Milan‐Mattos, J. C., Linares, S. N., Porta, A., da Silva, T. M., Fazan, R., Beltrame, T., & Catai, A. M. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.110223 · Cited by 11
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Classification and Clinical Features
Boulton, A. J. M., & Vileikytė, L. (2011) · Springer eBooks · doi:10.1007/978-0-85729-488-3_2 · Cited by 7
Diabetic Neuropathies
Weber, G. A., & Cardile, M. A. (1990) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/s0891-8422(23)00360-9 · Cited by 8
Sex Differences in the Association Between Cardiovascular Autonomic Neuropathy and Mortality in Patients With Type 2 Diabetes: The ACCORD Study
Zhou, Z., Huang, Y., Zhuang, X., Guo, Y., Xie, P., Xiong, Z., Liu, M., Zhang, W., Zhong, J., Li, Y., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.034626 · Cited by 9
Aberrant parasympathetic and hemodynamic function distinguishes a subgroup of psychologically distressed individuals with asymptomatic type-I diabetes mellitus
Motivala, S. J., Hurwitz, B., Lagreca, A., Llabre, M., Marks, J., Skyler, J., & Schneiderman, N. (1999) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0601_6 · Cited by 8
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Background
Does insulin play a role in cardiovascular autonomic regulation?
Sima, A. A. (2000) · Diabetes Care · doi:10.2337/diacare.23.6.724 · Cited by 7
Development of a method to determine autonomic nervous system function in the rat
Dunlap, E. D., Samols, E., Waite, L. C., et al. (1987) · Metabolism · doi:10.1016/0026-0495(87)90017-5 · Cited by 7
Self-citation
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SUPPLEMENTATION OF Α-LIPOIC ACID IN DIABETIC PERIPHERAL NEUROPATHY: A PROSPECTIVE OPEN LABEL RANDOMIZED CONTROLLED TRIAL
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Is treatment of type 1 diabetes mellitus (insulin therapy, metabolic control) optimal for preventing cardiovascular autonomic neuropathy?
Pawliński, Ł., Gastoł, J., Fiema, M., Matejko, B., & Kieć‐Wilk, B. (2019) · Endokrynologia Polska · doi:10.5603/ep.a2019.0011 · Cited by 6
“showed that people with T1DM, even after the first two years of the disease, may present early stages of CAN expressed by a reduction in the RR interval variation during b-adrenergic blockade [18].”
Background
Leisure-Time Physical Activity and Glycemic Control Independently Predicts Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus
Bhati, P., & Hussain, M. E. (2021) · Journal of Physical Activity and Health · doi:10.1123/jpah.2020-0194 · Cited by 6
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy.
Felício, J. S., Santos, F. M., de Souza, A. C. C., et al. (2010) · PubMed · Cited by 6
Cardiac Autonomic Neuropathy in Prediabetes: A Case-Control Study
Gujjar, P. K., Ravikumar, Y. S., Nagendra, L., Boro, H., & Bhattacharya, S. (2023) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_50_23 · Cited by 6
“[9] Cardiovascular autonomic neuropathy (CAN) is a common and extensively researched form of DAN because of its potentially fatal consequences (arrhythmias, latent myocardial ischemia and sudden death).”
Background
Autonomic nervous system function assessed by conventional and spectral analysis might be useful in terms of predicting retinal deterioration in persons with type 1 diabetes mellitus
Duvnjak, L. S., Tomić, M., Blaslov, K., & Rebrina, S. V. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.04.042 · Cited by 5
Acute Autonomic Responses to Postural Change, Valsalva Maneuver, and Paced Breathing in Older Type II Diabetic Men
Naliboff, B. D., Gilmore, S. L., & Rosenthal, M. J. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb06739.x · Cited by 6
Autonomic neuropathy in African diabetic patients
Tuch, P., Gill, G. V., & Huddle, K. (1994) · Postgraduate Medical Journal · doi:10.1136/pgmj.70.821.188 · Cited by 6
Diabetic Autonomic Neuropathy
Freeman, R. L. (1998) · Humana Press eBooks · doi:10.1007/978-1-4612-1816-6_12 · Cited by 7
Assessment of Time Domain and Spectral Components of Heart Rate Variability Immediately Before Ischemic ST Segment Depression Episodes
Dilaveris, P., Zervopoulos, G., Psomadaki, Z. D., et al. (1996) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1996.tb04212.x · Cited by 6
Short term heart rate variability for early assessment of autonomic neuropathy in patients with type 2 diabetes mellitus: A comparative cross-sectional study
Deepak, A., Khode, V., Nallulwar, S. C., et al. (2014) · Annals of Nigerian Medicine · doi:10.4103/0331-3131.141021 · Cited by 5
The vagus nerve cross-sectional area on ultrasound in patients with type 2 diabetes
Kotb, M. A., Bedewi, M. A., Almalki, D. M., et al. (2023) · Medicine · doi:10.1097/md.0000000000036768 · Cited by 5
“[2] The vagus nerve (VN) is the longest nerve in the autonomic nervous system and accounts for almost 2 thirds of the parasympathetic activity in the body.”
Background
Cardiovascular autonomic dysfunction predicts increasing albumin excretion in type 1 diabetes
Lu, L., Marcovecchio, M. L., Dalton, R. N., et al. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12614 · Cited by 5
“1 diabetes (T1D), which has been observed as early as 2 years after T1D diagnosis.(1) A recent systematic review has reported a variable”
Background
Metabolic Syndrome and Inflammation
Pop‐Busui, R., & Pietropaolo, M. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-478-4_5 · Cited by 5
Complicaciones crónicas, factores de riesgo cardiovascular y HbA1c en la diabetes mellitus tipo 1 a los 14 años de diagnóstico
Martínez-Riquelme, A., Castell, C., Mabres, C., et al. (2005) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(05)71048-2 · Cited by 4
Neuropsychological Sequelae of Chronic Medical Disorders in Children and Youth
Berg, R. A., & Linton, J. C. (2008) · Springer eBooks · doi:10.1007/978-0-387-78867-8_27 · Cited by 4
500 heart beats for assessing diabetic autonomic neuropathy
Lafitte, M., Fevre-Genoulaz, M., Srikanta, S., et al. (2005) · International Journal of Diabetes in Developing Countries · doi:10.4103/0973-3930.27016 · Cited by 4
“, Parkinson’s disease, epilepsy, recent stroke); (2) coronary artery disease or congestive heart failure; (3) a creatinine clearance <30 ml/min; (4) pregnancy; and (5) use of medications with potential influence on autonomic nerve function (e.”
BackgroundMethod
Tratamiento de la neuropatía autonómica diabética
Millán, C. O. (2005) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/s1134-2072(05)71266-4 · Cited by 4
Predictors of Cardiovascular Autonomic Neuropathy in Diabetic Patients: A Cross-Sectional Study from Basrah
Mansour, A. A., & Odea, A. (2013) · Research in Endocrinology · doi:10.5171/2013.301170 · Cited by 4
Raccomandazioni sull’uso dei test cardiovascolari nella diagnosi di neuropatia autonomica diabetica
Spallone, Bax, G., Bellavere, F., Esposito, K., Melga, P., Morganti, R., Quadri, R., Scionti, L., Viviani, G. L., & Diabetica”, P. I. G. D. S. S. “. (2007) · Cited by 4
Influence of posture on cardiorespiratory reflexes in normal subjects and patients with diabetes mellitus
Navarro, X., & Kennedy, W. R. (1992) · Clinical Autonomic Research · doi:10.1007/bf01831397 · Cited by 4
Kardiovaskuläre und pupilläre autonome und somatosensible Neuropathie bei chronischen Erkrankungen mit Autoimmunphänomenen
Straub, R. H., Andus, T., Lock, G., et al. (1997) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/bf03044820 · Cited by 4
Commentary: Recognizing pupillary dysfunction in diabetic autonomic neuropathy
Sudhakar, P. P. (2019) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_794_19 · Cited by 4
The evaluation of pupil diameter by using Sirius before and after phacoemulsification in healthy, diabetic and hypertension patients
Şimşek, A., & Toptan, M. (2023) · Medicine · doi:10.1097/md.0000000000033223 · Cited by 3
“However, subclinical autonomic neuropathy may be detected in 1 to 2 years following diagnosis of diabetes.[28] The study group in the present study consisted of five-year non-proliferative DM patients.”
Background
Prevalence and patterns of cardiac autonomic dysfunction in male patients with type 2 diabetes mellitus and chronic Charcot’s neuroarthropathy: a cross-sectional study from South India
Naik, D., Singh, H. S., Gupta, R. D., et al. (2019) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-019-00722-5 · Cited by 3
Cardiac Autonomic Neuropathy- An ECG Correlation in Type 2 Diabetes
Vijayan, S., Ganesamoorthy, K., Padmini, U., et al. (2019) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2019/593 · Cited by 3
Evaluating Yoga-Based Intervention Versus the American Diabetes Association Exercise Regimen in Conjunction With Standard Care for Autonomic Neuropathy in Diabetes Mellitus: An Exploratory Clinical Trial
Kumar, R. K., Dhamija, P., Vardhan, G., Kant, R., Singh, Y., Yadav, R. K., Rudra, B., & Pathania, M. (2024) · Cureus · doi:10.7759/cureus.61329 · Cited by 3
“AFT data recording process was adopted [15,16].”
Pupillary light reflex in borderline diabetes mellitus
Kuroda, N., Taniguchi, H., Baba, S., et al. (1989) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(89)90111-3 · Cited by 3
Peripheral and Autonomic Neuropathy in an Adolescent with Type 1 Diabetes Mellitus: Evidence of Symptom Reversibility after Successful Correction of Hyperglycemia
Rojas, J., Chávez-Castillo, M., Torres, W., Chávez, C., Apruzzese, V., Cabrera, M., & Bermúdez, V. (2014) · Journal of Research in Diabetes · doi:10.5171/2014.899900 · Cited by 2
“Usually, it appears first in longer nerves such as the Vagus nerve, which encompasses 75% of all parasympathetic activity (Vinik, Freeman & Erbas, 2003), and although symptoms tend to present in patients with longer time of evolution, subclinical DAN has been recognized to appear within the first 2 years after diagnos…”
BackgroundInfluential
Oxidative Stress Reduction (Prong-3)
DePace, N. L., & Colombo, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-17016-5_5 · Cited by 3
Autonome Störungen bei Polyneuropathien
Hilz, M. J., Dütsch, M., & Neundörfer, B. (1998) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/bf03042662 · Cited by 3
Diabetes and the Autonomic Nervous System
Pozza, G., & Sora, M. G. N. (2002) · CRC Press eBooks · doi:10.1201/9780203908891.ch17 · Cited by 3
EVALUATION OF AUTONOMIC DYSFUNCTION BY HEART RATE VARIABILITY ANALYSIS IN TYPE 2 DIABETES MELLITUS
Nil, P. N., & Ferdousi, S. (2016) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v10i1.15344 · Cited by 2
Does dysfunction of the autonomic nervous system affect success of renal denervation in reducing blood pressure?
Fricke, L., Petroff, D., Desch, S., Lurz, P. C., Reinhardt, S., Sonnabend, M., Claßen, J., & Baum, P. (2017) · SAGE Open Medicine · doi:10.1177/2050312117702031 · Cited by 2
Autonomic History Taking and Key Symptoms: Where Is the Autonomic Disease?
Fanciulli, A., Indelicato, E., & Wenning, G. K. (2017) · Springer eBooks · doi:10.1007/978-3-319-05143-7_2 · Cited by 2
Effects of Pancreas Transplantation on Secondary Complications of Diabetes
Fioretto, P., Mauer, M. S., Walsh, A. W., Elliott, M. D., Chen, M., Kaufman, D. B., Navarro, X., Kennedy, W. R., Gaber, A. O., Cashion, A. K., et al. (2004) · Springer eBooks · doi:10.1007/978-1-4757-4371-5_16 · Cited by 2
Autonomic Neuropathy in Diabetes in Pregnancy
Myers, J. (2010) · Wiley eBooks · doi:10.1002/9781444315196.ch18 · Cited by 2

Authors: Pfeifer, M. A., Weinberg, C. R., Cook, D. L., Reenan, A., Halter, J. B., Ensinck, J. W., & Porte, D.
Affiliations: United States Department of Veterans Affairs (US)
Departments of Medicine and Biostatistics, Universities of Washington and Louisville, The Geriatric Research Education and Clinical Center at the Seattle VA Medical Center, and the Louisville and Seattle Veterans Administration Medical Centers
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 1984-09-01
Volume: 7
Issue: 5
Pages: 447-453
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/diacare.7.5.447
OpenAlex: W2088352152
Cited by: 266
References: 0
Citations by year: 2026: 1 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 12 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 9
FWCI: 4.08
Type: journal article
Language: en
Open access: closed
Locations: Diabetes Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Keywords: diabetic autonomic neuropathy, autonomic dysfunction, type 1 diabetes, type 2 diabetes, recent-onset diabetes, heart rate variability, beta-adrenergic blockade, pupil size, furosemide, hypovolemia, carbohydrate metabolism
MeSH terms: Adult, Aged, Autonomic Nervous System, Autonomic Nervous System Diseases, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Electrocardiography, Female, Heart, Humans, Male, Middle Aged, Reflex, Abnormal, Reflex, Pupillary, Vasomotor System

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Autonomic Neural Dysfunction in Recently Diagnosed Diabetic Subjects

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