Insulin Use in Pregnancy: An Update
Open accessAbstract
IN BRIEF Insulin remains the standard of care for the treatment of type 1 diabetes, type 2 diabetes, and uncontrolled gestational diabetes. Tight control maintained in the first trimester and throughout pregnancy plays a vital role in decreasing poor fetal outcomes, including structural anomalies, macrosomia, hypoglycemia of the newborn, adolescent and adult obesity, and diabetes. Understanding new insulin formulations and strengths is important in assessing risks, since no data on their use in human pregnancy exist.
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The safety of human insulin use in pregnancy was demonstrated.
“The safety of human insulin use in pregnancy was demonstrated [103].”
From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [103]
The “Insulin Safety in Pregnancy” section says regular insulin and NPH have sufficient human data to be considered low risk. But it also says inhaled human insulin has no human pregnancy data, so the paper does not demonstrate the safety of human insulin use without qualification. (LLM, conf=0.82)
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Cites
Hyperglycemia and adverse pregnancy outcomes
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The predisposition to obesity and diabetes in offspring of diabetic mothers
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Maternal Glycemic Control and Hypoglycemia in Type 1 Diabetic Pregnancy
Mathiesen, E. R., Kinsley, B., Amiel, S. A., Heller, S., McCance, D., Duran, S., Bellaire, S., Raben, A., & on behalf of the Insulin Aspart Pregnancy Study Group (2007) · Diabetes Care · doi:10.2337/dc06-1887 · Cited by 265 · see citing works
Flagged first, then by citations
Research works printed but not linked: 9
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Cited by
Sorted by citations
Gestational Diabetes Mellitus—Recent Literature Review
Modzelewski, R., Stefanowicz-Rutkowska, M. M., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195736 · Cited by 223 · see citing works
Moyce, B. L., & Dolinsky, V. W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113467 · Cited by 128 · see citing works
- Authors
- Blum, A. K.
- Affiliations
- Washington State University Spokane (US)
- Corresponding author
- Blum, Alyson K.
- Venue
- Diabetes Spectrum
- Publisher
- American Diabetes Association
- Published
- 2016-05-01
- Volume
- 29
- Issue
- 2
- Pages
- 92-97
- ISSN
- 1040-9165 (ISSN-L)
- 1944-7353
- PMC
- PMC4865394
- OpenAlex
- W2396123278
- Cited by
- 59
- References
- 5
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 1 · 2015: 1
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Spectrum (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- insulin therapy in pregnancy, gestational diabetes mellitus, type 1 diabetes in pregnancy, type 2 diabetes in pregnancy, glycemic control, insulin formulations, insulin analogues, fetal outcomes, macrosomia, neonatal hypoglycemia, obesity
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