Maternal β-Cell Adaptations in Pregnancy and Placental Signalling: Implications for Gestational Diabetes
Open accessAbstract
Rates of gestational diabetes mellitus (GDM) are on the rise worldwide, and the number of pregnancies impacted by GDM and resulting complications are also increasing. Pregnancy is a period of unique metabolic plasticity, during which mild insulin resistance is a physiological adaptation to prioritize fetal growth. To compensate for this, the pancreatic β-cell utilizes a variety of adaptive mechanisms, including increasing mass, number and insulin-secretory capacity to maintain glucose homeostasis. When insufficient insulin production does not overcome insulin resistance, hyperglycemia can occur. Changes in the maternal system that occur in GDM such as lipotoxicity, inflammation and oxidative stress, as well as impairments in adipokine and placental signalling, are associated with impaired β-cell adaptation. Understanding these pathways, as well as mechanisms of β-cell dysfunction in pregnancy, can identify novel therapeutic targets beyond diet and lifestyle interventions, insulin and antihyperglycemic agents currently used for treating GDM.
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In gestational diabetes mellitus, β-cell insulin secretion is not sufficient to compensate for the insulin resistance of pregnancy, resulting in hyperglycemia during pregnancy.
“In GDM, β-cell insulin secretion is not sufficient to compensate for the insulin resistance of pregnancy, resulting in hyperglycemia during pregnancy [55].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [55]
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Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications
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Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space
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The Role of Adiponectin during Pregnancy and Gestational Diabetes
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Self-citationThe human placenta and its role in reproductive outcomes revisited
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“In GDM, β-cell insulin secretion is not sufficient to compensate for the insulin resistance of pregnancy, resulting in hyperglycemia during pregnancy [55].”
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Intimate Partner Violence: A Risk Factor for Gestational Diabetes
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Adiponectin Promotes Maternal β-Cell Expansion Through Placental Lactogen Expression
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Steroids, steroid associated substances and gestational diabetes mellitus
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Research Progress on the Experimental Animal Model of Gestational Diabetes Mellitus
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Maternal Diabetes and Postnatal High-Fat Diet on Pregnant Offspring
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The Essential Role of Pancreatic α-Cells in Maternal Metabolic Adaptation to Pregnancy
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Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus
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Shryack, G. E., Krause, A. A., Ruano, S. H., Schulz, L. C., Pennington, K. A., & Rector, R. S. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1498764 · Cited by 1 · see citing works
Maternal Obesity Programs Glucose Intolerance in Pregnant Female Offspring
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- Authors
- Moyce, B. L., & Dolinsky, V. W.
- Affiliations
- Department of Pharmacology & Therapeutics and the Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Research Theme of the Children’s Hospital Research Institute of Manitoba and the Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION), University of Manitoba, Winnipeg, MB R3E 3P4, Canada
- Children's Hospital Research Institute of Manitoba (CA)
- Corresponding author
- Dolinsky, Vernon W.
- ORCID
- Dolinsky, Vernon W.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-11-05
- Volume
- 19
- Issue
- 11
- Pages
- 3467
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6274918
- OpenAlex
- W2900236795
- Cited by
- 128
- References
- 93
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 16 · 2023: 13 · 2022: 21 · 2021: 21 · 2020: 19 · 2019: 4
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Canadian Institutes of Health Research (136885)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- gestational diabetes mellitus, insulin resistance in pregnancy, adipokines, lipotoxicity, inflammation, oxidative stress, beta-cell dysfunction, glucose homeostasis, hyperglycemia, therapeutic target
- MeSH terms
- Adaptation, Physiological, Female, Humans, Placenta, Pregnancy, Signal Transduction, Diabetes, Gestational, Oxidative Stress, Insulin-Secreting Cells
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