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Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?
Open accessAbstract
Persistent, itching nodules have been reported to appear at the injection site after allergen-specific immuno-therapy with aluminium-precipitated antigen extract, occasionally in conjunction with contact allergy to aluminium. This study aimed to quantify the development of contact allergy to aluminium during allergen-specific immunotherapy. A randomized, controlled, single-blind multicentre study of children and adults entering allergen-specific immunotherapy was performed using questionnaires and patch-testing. A total of 205 individuals completed the study. In the 3 study groups all subjects tested negative to aluminium before allergen-specific immunotherapy and 4 tested positive after therapy. In the control group 4 participants tested positive to aluminium. Six out of 8 who tested positive also had atopic dermatitis. Positive test results were found in 5/78 children and 3/127 adults. Allergen-specific immunotherapy was not shown to be a risk factor for contact allergy to aluminium. Among those who did develop aluminium allergy, children and those with atopic dermatitis were more highly represented.
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Contact allergy to Al has been reported as an aberrant immune response in those having atopic dermatitis.
“Contact allergy to Al has been reported as an aberrant immune response in those having atopic dermatitis (Netterlid et al., 2013).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Netterlid et al., 2013
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Metadata
- Authors
- Netterlid, E., Hindsén, M., Siemund, I., Björk, J., Werner, S., Jacobsson, H., Güner, N., & Bruze, M.
- Affiliations
- Lund University (SE)
- Skåne University Hospital (SE)
- Venue
- Acta Dermato Venereologica
- Published
- 2013
- Volume
- 93
- Issue
- 1
- Pages
- 50-56
- ISSN
- 0001-5555 (ISSN-L)
- OpenAlex
- W2107911772
- Cited by
- 35
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Acta Dermato Venereologica (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- allergen immunotherapy, patch testing, atopic dermatitis, children, adults
- MeSH terms
- Adolescent, Adult, Aged, Allergens, Aluminum, Child, Preschool, Dermatitis, Atopic, Dermatitis, Contact, Desensitization, Immunologic, Female, Humans, Male, Middle Aged, Patch Tests, Surveys and Questionnaires, Single-Blind Method, Young Adult
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