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Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis
Open accessAbstract
The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.
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Doxycycline 100 mg once or twice daily for 14 days is effective for syphilis.
“although 100 mg once (OD) or twice daily (BD) for 14 days is effective,92–96”
From BASHH UK guidelines for the management of syphilis 2024 (2024) · cites this paper as [95]
The paper states that syphilis is treated with penicillin or doxycycline in Denmark and reports no documented treatment failures. It does not specify a doxycycline dose or 14-day course, and its Discussion says the study cannot definitively rule out treatment failures. Thus it does not establish the claimed effectiveness of either regimen. (LLM, conf=0.86)
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BASHH UK guidelines for the management of syphilis 2024
Kingston, M., Apea, V., Evans, C., Fifer, H., Foster, K., Patrick, P., Grant, A., Manns, V., Ramsden, S., Sinka, K., et al. (2024) · International Journal of STD & AIDS · doi:10.1177/09564624241280406 · Cited by 51
Metadata
- Authors
- Salado-Rasmussen, K., Cowan, S., Gerstoft, J., Larsen, H., Hoffmann, S., Knudsen, T., Katzenstein, T., & Jensen, J.
- Affiliations
- Statens Serum Institut (DK)
- Copenhagen University Hospital (DK)
- Bispebjerg Hospital (DK)
- Hvidovre Hospital (DK)
- Venue
- Acta Dermato Venereologica
- Published
- 2016
- Volume
- 96
- Issue
- 2
- Pages
- 202-206
- ISSN
- 0001-5555 (ISSN-L)
- OpenAlex
- W2319377630
- Cited by
- 30
- References
- 1
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 3
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Acta Dermato Venereologica (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Funders
- Bristol-Myers Squibb
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- University of Washington
- Augustinus Fonden
- AIDS Fondet
- Fonden til Lægevidenskabens Fremme
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- Treponema pallidum, syphilis, molecular strain typing, HIV coinfection, Denmark
- MeSH terms
- Bacterial Outer Membrane Proteins, Denmark, DNA, Bacterial, Female, Genotype, Health Surveys, Humans, Male, Prognosis, Syphilis, Time Factors, Treponema pallidum, Bacterial Typing Techniques, HIV Infections, Polymerase Chain Reaction, Molecular Epidemiology, Coinfection
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