Predictors of pain and function outcome after rehabilitation in patients with patellofemoral pain syndrome
Open accessAbstract
OBJECTIVE: To identify changes in impairments associated with functional and pain outcome in patients with patello-femoral pain syndrome following a standardized physiotherapy treatment. DESIGN: One group pre-post design. SUBJECTS: Seventy-four patients (median age 27 years, 52% female) diagnosed with patellofemoral pain syndrome and referred to physiotherapy treatment. METHODS: Baseline measures included self-reported function and pain, which were the dependent variables, and measures of independent variables: strength of quadriceps, hip abduction and hip external rotation; length of hamstrings, quadriceps, plantar flexors, iliotibial band/tensor fascia lata complex, and lateral retinaculum; quality of movement, and fear-avoidance beliefs. Following the baseline measurements, subjects participated in a standardized physiotherapy program. Measurements were repeated at 2-month follow-up. Data were analyzed using 2 forward regression models, the first using function outcome, and the second using pain outcome as the criterion. Age, gender, height and weight were controlled in the regression models. RESULTS: Change in fear-avoidance beliefs about physical activity and change in gastrocnemius length predicted function outcome. Change in fear-avoidance beliefs about physical activity and about work predicted outcome of pain. CONCLUSION: Change in fear-avoidance beliefs about physical activity was the strongest predictor of function and pain outcome. The fact that patients who decreased their fear-avoidance beliefs improved function and decreased pain indicates that perhaps fear-avoidance beliefs should be targeted during the treatment of patients with patellofemoral pain syndrome.
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From Beyond yellow flags: The Big‐Five personality traits and psychologically informed musculoskeletal rehabilitation. (2023) · cites this paper as Piva et al., 2009
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Selhorst, M., Fernandez-Fernandez, A., Schmitt, L. C., & Hoehn, J. (2020) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2020.07.003 · Cited by 18 · see citing works
Barke, A., Preis, M. A., Schmidt‐Samoa, C., Baudewig, J., Kröner‐Herwig, B., & Dechent, P. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.05.005 · Cited by 23 · see citing works
Glaviano, N. R., Baellow, A. L., & SALIBA, S. A. (2018) · Athletic Training & Sports Health Care · doi:10.3928/19425864-20181029-01 · Cited by 18 · see citing works
Smith, B. E., Hendrick, P. A., Bateman, M., Moffatt, F., Rathleff, M. S., Selfe, J., Smith, T. O., & Logan, P. (2017) · Pilot and Feasibility Studies · doi:10.1186/s40814-017-0167-2 · Cited by 16 · see citing works
Patellofemoral Pain Syndrome: An Update
Hryvniak, D. J., Magrum, E. M., & Wilder, R. (2014) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-014-0044-3 · Cited by 16 · see citing works
“Despite the fact that physical therapy is the most frequently used conservative treatment for PFPS, studies report that approximately 25 % of patients continue to have pain and dysfunction for more than 1 year after rehabilitation has been completed [70].”
BackgroundPrugh, J., Zeppieri, G., & George, S. Z. (2012) · Physiotherapy Theory and Practice · doi:10.3109/09593985.2012.666632 · Cited by 16 · see citing works
Williams, M. K., Waite, L., Van Wyngaarden, J. J., Meyer, A. R., & Koppenhaver, S. L. (2023) · Musculoskeletal Care · doi:10.1002/msc.1797 · Cited by 15 · see citing works
Selhorst, M., Rice, W., Jackowski, M., Degenhart, T., & Coffman, S. (2018) · Clinical Rehabilitation · doi:10.1177/0269215518787002 · Cited by 15
Papadopoulos, K., Noyes, J., Barnes, M., Jones, J. G., & Thom, J. (2012) · International Journal of Therapy and Rehabilitation · doi:10.12968/ijtr.2012.19.5.261 · Cited by 15 · see citing works
Wride, J., & Bannigan, K. (2019) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2018-0347 · Cited by 19 · see citing works
Simon, C., Stryker, S., & George, S. (2011) · Journal of Pain Research · doi:10.2147/jpr.s22457 · Cited by 13 · see citing works
“Further, work-related fear-avoidance beliefs have been associated with pain and disability for patients with other disorders such as mechanical neck pain(14) and patellofemoral pain.(15)”
Cabell, G. H., Kwon, N. F., Sutton, K. F., Lentz, T. A., Lewis, B. D., Olson, S., & Mather, R. (2023) · Arthroscopy, Sports Medicine, and Rehabilitation · doi:10.1016/j.asmr.2023.100846 · Cited by 12 · see citing works
“The high distress class had the lowest mean (SD) iHOT-12 score of 23.5 (17.6), while the low distress class had the largest (47.2 [21.3]) (Table 3).”
BackgroundInfluentialPatellofemoral pain: Challenging current practice - A case report.
Smith, B. E., Hendrick, P., & Logan, P. (2016) · Manual Therapy · doi:10.1016/j.math.2015.09.002 · Cited by 12 · see citing works
Selhorst, M., Hoehn, J., Schmitt, L., Benedict, J., & Fernandez-Fernandez, A. (2023) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2023.12041 · Cited by 11 · see citing works
Straszek, C. L., Rathleff, M., Graven-Nielsen, T., Petersen, K. K., Roos, E., & Holden, S. (2019) · European Journal of Pain · doi:10.1002/ejp.1452 · Cited by 11 · see citing works
Mansfield, C., & Selhorst, M. (2018) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2018.10.008 · Cited by 11 · see citing works
Esculier, J., Bouyer, L., Dubois, B., Leblond, J., Brisson, M., Chau, L., & Roy, J. (2018) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2018.01.006 · Cited by 11 · see citing works
Peng, H.-T., & Song, C.-Y. (2015) · Knee (Oxford) · doi:10.1016/j.knee.2014.10.012 · Cited by 11
“Someof the studies enrolled an athletic population [4,5].”
BackgroundInfluentialYalfani, A., & Ahmadi, M. (2024) · Journal of Bodywork & Movement Therapies · doi:10.1016/j.jbmt.2024.04.026 · Cited by 9 · see citing works
Shadloo, N., Kamali, F., & Dehno, N. S. (2021) · Journal of Bodywork & Movement Therapies · doi:10.1016/j.jbmt.2021.03.003 · Cited by 9 · see citing works
Liew, B., Rügamer, D., Abichandani, D., & Nunzio, A. M. D. (2020) · Gait & Posture · doi:10.1016/j.gaitpost.2020.05.034 · Cited by 9 · see citing works
Villafañe, J., Bissolotti, L., Touche, R. L., Pedersini, P., & Negrini, S. (2019) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1938224.112 · Cited by 9 · see citing works
“Psychological components (depression, fear-avoidance, and anxiety) are also reported as risk factors for the onset and persistence of PFPS (Piva et al., 2009), then, both contributing factors and pathophysiology of PFPS are considered multifactorial.”
BackgroundKim, S., Callahan, E., Malone, Z. C., Gilgallon, T. J., & Glaviano, N. R. (2023) · Journal of sport rehabilitation · doi:10.1123/jsr.2023-0160 · Cited by 6
Genoese, F. M., Baez, S., & Hoch, J. (2018) · International Journal of Athletic Therapy & Training · doi:10.1123/ijatt.2017-0108 · Cited by 6 · see citing works
Hoffman, E., D'Onofrio, A., Baez, S., & Cavallario, J. M. (2018) · International Journal of Athletic Therapy & Training · doi:10.1123/ijatt.2017-0044 · Cited by 6 · see citing works
The association between kinesiophobia and functional limitations in service members with knee pain.
Pontillo, M., Gunterstockman, B., Mauntel, T., & Farrokhi, S. (2023) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2023.102766 · Cited by 5 · see citing works
Fear of movement in patients after anterior cruciate ligament reconstruction
Clifford, A. M., Buckley, E., O’Farrell, D., Louw, Q. A., & Moloney, C. (2017) · Physiotherapy Practice and Research · doi:10.3233/ppr-170098 · Cited by 5 · see citing works
Influence of Psychological Factors on Pain and Disability in Anterior Knee Pain Patients
Domenech, J., Sanchis-Alfonso, V., & Espejo, B. (2011) · Springer eBooks · doi:10.1007/978-1-4471-4495-3_9 · Cited by 5 · see citing works
Ambrus, M., Wolf, G., Molnár, D., Soussi, B., Horváth, T., Horváth, M., & Lacza, Z. (2026) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-026-09556-9 · Cited by 4
“Although it is less frequently examined in isolation, training of the hip and core in patients suffering from patellofemoral pain syndrome has also been linked to functional advancements in the aspects measured by the Lysholm scale [28].”
Martins, D., de Castro, M. D., Ruschel, C., Pierri, C. A. A., Fontana, H. D. B., & Santos, G. M. (2022) · International Journal of Sports Physical Therapy · doi:10.26603/001c.31044 · Cited by 4
Lowry, V., Bass, A., Vukobrat, T., Décary, S., Belisle, P., Sylvestre, M., & Desmeules, F. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04534-9 · Cited by 4 · see citing works
Assessment, Reasoning and Management of Psychological Factors in Musculoskeletal Practice
Beneciuk, J., George, S., & Jones, M. A. (2019) · Clinical Reasoning in Musculoskeletal Practice · doi:10.1016/b978-0-7020-5976-6.00009-7 · Cited by 4 · see citing works
Kong, W., Wang, Z.-R., Zhou, Q., Yan, X., Li, J.-Y., Zhao, Y., Wang, X., Wang, H.-N., & Ni, G.-X. (2025) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2025.06.003 · Cited by 3 · see citing works
Chen, P., Wang, L., Zhou, W., & Wang, L. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299008 · Cited by 3
Maryam, E., Mahbobeh, S., Farzaneh, M., Fatemeh, K., & Zohreh, N. (2022) · Physiotherapy Quarterly · doi:10.5114/pq.2021.108670 · Cited by 3
“Furthermore, according to the fear avoidance model, fear of pain is associated with functional disability and muscle weakness [52, 53].”
BackgroundBalblanc, M., Lohse, A., Meyer, F., Rapp, C., Bourgoin, C., Balblanc, J., & Conrozier, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185372 · Cited by 2
“Patellofemoral syndrome is a condition that is difficult to treat, in which fear-avoidance beliefs are the main predictor of rehabilitation outcome [43,44].”
BackgroundGolpayegani, M., Fayazi, Z., & Hoseini, Y. (2021) · مجله دانشگاه علوم پزشکی اراک · doi:10.32598/jams.24.5.6275.1 · Cited by 2 · see citing works
Ghordadekar, D. R., & Kapoor, A. (2021) · Indian Journal of Forensic Medicine & Toxicology · doi:10.37506/ijfmt.v15i1.13373 · Cited by 2 · see citing works
“The fact that patients who decreased their fear-avoidance beliefs improved function and decreased pain indicates that perhaps fear-avoidance beliefs should be targeted during the treatment of patients with patellofemoral pain syndrome(21).”
BackgroundLeibbrandt, D. C., & Louw, Q. (2019) · South African Journal of Physiotherapy · doi:10.4102/sajp.v75i1.684 · Cited by 2 · see citing works
“Changes in fear-avoidance behaviour have been suggested as an important predictor of functional outcome in patients with PFP (Piva et al. 2009).”
BackgroundKarimzadehfini, A., Zolaktaf, V., & Vahdatpour, B. (2014) · Advanced Biomedical Research · doi:10.4103/2277-9175.139128 · Cited by 2
“Decreased flexibility in the hamstrings can increase the demand on the quadriceps during extension of the knee and increased joint forces at the patella-femoral joint.[24] Tight lateral structures contribute to a lateral patella pull and result in patella displacement.”
BackgroundMethodInfluentialPredictors for patients with knee complaints receiving physiotherapy
Karstens, S., Hermann, K., Froböse, I., & Weiler, S. W. (2014) · European Journal of Physiotherapy · doi:10.3109/21679169.2013.852241 · Cited by 2 · see citing works
Darjee, J. P., & Sahai, N. (2026) · Journal of Physics, Conference Series · doi:10.1088/1742-6596/3196/1/012065 · Cited by 1
“The study shows that the impact of the persisting pain is enough to affect the quality of life, including sports participation and career selection (19). assemble a multidisciplinary team including clinicians, software developers, and user experience designers.”
Canino, M., Arvin, N., Nachazel, Z., Irrgang, J. J., Popchak, A. J., Musahl, V., Sterczala, A. J., & Flanagan, S. D. (2025) · Experimental Brain Research · doi:10.1007/s00221-025-07003-0 · Cited by 1 · see citing works
“…et al. 1993 ), modifications were implemented to ensure knee specificity and has been previously used in patients with knee osteoarthritis (van Baar et al. 1998), patellofemoral pain syndrome (Piva et al. 2009), and ACL injuries (Geno-ese et al. 2020 ; Baez et al. 2021; Barchek et al. 2021).”
- Authors
- Piva, Sr., Fitzgerald, G., Wisniewski, S., & Delitto, A.
- Venue
- Journal of Rehabilitation Medicine
- Published
- 2009
- Volume
- 41
- Issue
- 8
- Pages
- 604-612
- ISSN
- 1650-1977 (ISSN-L)
- OpenAlex
- W2017982646
- Cited by
- 133
- References
- 36
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 4 · 2015: 5 · 2014: 12 · 2013: 5 · 2012: 8
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Rehabilitation Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Physical Therapy Association
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Myofascial pain diagnosis and treatment
- Keywords
- patellofemoral pain, fear-avoidance beliefs, physiotherapy, pain outcomes, functional outcome, quadriceps strength, hip external rotation, hamstring length, iliotibial band, lateral retinaculum, movement quality, prognostic factors
- MeSH terms
- Adolescent, Adult, Child, Fear, Female, Humans, Male, Middle Aged, Pain Measurement, Prognosis, Exercise, Range of Motion, Articular, Treatment Outcome, Outcome Assessment, Health Care, Physical Therapy Modalities, Patellofemoral Pain Syndrome, Muscle Strength, Young Adult
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