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Anxiety after stroke: A systematic review and meta-analysis
Open accessAbstract
Anxiety is common during the first year after you have been diagnosed with stroke, with one in three experiencing it.Today anxiety after stroke gets significantly less attention compared to other psychological problems after stroke and one has reported dissatisfaction with the provision of psychological services after stroke.Since anxiety significantly influences quality of life, it is prevalent, and could be a predictor for depression.In this review, we have looked at the prevalence of anxiety at different times after stroke.We found that 29.3% of the patients had some form of anxiety disorders during the first year after stroke.The highest frequency, 36.7%, was 0-2 weeks after stroke onset.We suggest that clinicians should be more aware of anxiety that further routine screening post stroke may be worth considering providing appropriate interventions.Objective: To update the evidence surrounding the presence of anxiety after stroke.Data sources: A search was conducted in EMBASE, MEDLINE, PsycINFO, Cochrane Library, AMED and CINAHL in May 2015 and repeated in April 2017.Study selection: Clinical diagnosis of stroke and assessed for anxiety symptoms on a rating scale in the first year after stroke.Data extraction: One reviewer screened and identified studies against the inclusion criteria.A second reviewer conducted a random check of approximately 10% of titles and abstracts.Two authors independently performed the final full-text review.Data synthesis: Overall pooled prevalence of anxiety disorders was 29.3% ((95% confidence interval 24.8-33.8%),(I 2 = 97%, p < 0.00001)) during the first year.Frequency 0-2 weeks post-stroke was 36.7%, 2 weeks to 3 months 24.1%, and 3-12 months 23.8%.There was a statistically high heterogeneity in this estimate (I 2 = 97%, p < 0.00001).Conclusion: Anxiety is common during the first year post-stroke.Since anxiety significantly influences quality of life and is a predictor for depression, it may be worth considering further routine screening post-stroke.
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“Although treating these symptoms remains a challenge, evidence suggests that Acceptance and Commitment Therapy (ACT) can be an effective treatment for ABI-related anxiety and depressive symptoms (10–13).”
From Trial-based economic evaluation of the BrainACT study: acceptance and commitment therapy for anxiety and/or depressive symptoms after acquired brain injury. (2025) · cites this paper as [11]
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“…a topic that is still not fully understood, especially in post-stroke populations. immediately post stroke, patients tend to have increased anxiety 19 caused by a change to personal routine and future uncertainty, which typically dissipates with time. anxiety can moderate user experience when…”
Post-Stroke Rehabilitation: A Necessary Step
Rodríguez, I. B., Casado, L. G.-T., Borrella, Ó. D., Feito, P. G., Sánchez-Serrano, I., & Blanco, R. D. L. F. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102971 · Cited by 4
Olsson, C., & Schalling, E. (2025) · Disability and Rehabilitation · doi:10.1080/09638288.2025.2458182 · Cited by 2
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Poststroke anxiety and depression: epidemiology, mechanisms, and management strategies
Xie, Y., Wang, D., Shi, Q., Zhou, L., & Ai, T. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1756085 · Cited by 2
“Systematic reviews indicate that approximately one third of patients develop depressive symptoms at various stages after stroke, while the prevalence of anxiety is approximately 20 to 30 percent, and comorbidity between the two is frequent (3 – 5).”
Palliative care approaches to acute stroke in the hospital setting
Greenway, M. R. F., & Robinson, M. T. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-824535-4.00010-0 · Cited by 2
Othman, N., Din, S., Sharoni, S. K. A., & Mazlan, S. A. (2024) · The Malaysian Journal of Nursing · doi:10.31674/mjn.2024.v15i03.014 · Cited by 2
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A record-linkage study of post-stroke primary care psychological therapy effectiveness in England
Suh, J. W., Bell, V., Buckman, J. E. J., Baou, C. E., Desai, R., Fearn, C., Marchant, N. L., Richards, M., Cooper, C., Pilling, S., et al. (2025) · Nature Mental Health · doi:10.1038/s44220-025-00429-z · Cited by 2
“It is estimated that depression affects one in three stroke survivors 4 and can persist for years without intervention 5 , while anxiety affects more than one in four stroke survivors 6,7 .”
Kabedi, N. N., Kayembe, D. L., & Mwanza, J.-C. (2020) · Seminars in Ophthalmology · doi:10.1080/08820538.2020.1774623 · Cited by 2
The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke
Wang, Q., Xu, M., Xiao, M., Luan, X., Chen, H., Ruan, Y., Wang, L., Tu, Y., Huang, G., & He, J. (2022) · Psychogeriatrics · doi:10.1111/psyg.12799 · Cited by 2
Tynterova, A., Shusharina, N., Barantsevich, E., Khoymov, M., & Rozhdestvensky, A. (2024) · The European Physical Journal Special Topics · doi:10.1140/epjs/s11734-023-01052-8 · Cited by 2
“…population studies, which demonstrated that the prevalence of post-stroke depression can reach 60%, anxiety—24–30%, aggressive behavior is found in about 35% of patients, and the incidence of post-stroke apathy in stroke patients varies from 22.5 to 56.7% according to different authors [6–8].”
InfluentialLin, J., He, J., Shu, B., & Jia, J. (2020) · doi:10.21203/rs.3.rs-27503/v1 · Cited by 2
“It has good reliability, criterion, construct, factorial, and procedural validity [74,75].”
BackgroundMay, A. D., Roccaforte, A., Johnson-Markve, B. L., & Rodriguez-Flores, I. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197525456.013.0042 · Cited by 2
Anxiety Network of Brain Function in Patients with Acute Cerebral Infarction
Li, H., Gui, H., Yao, Y., & Lin, J. (2021) · Health · doi:10.4236/health.2021.137060 · Cited by 1
PREVALENCE OF ANXIETY AND DEPRESSION IN PATIENTS AFTER BRAIN STROKE
Mishchenko, M. M., Ognev, V. A., Mishchenko, O., & Ponomaryov, V. I. (2023) · Clinical and Preventive Medicine · doi:10.31612/2616-4868.4(26).2023.06 · Cited by 1
“So, Rafsten L. et al [11] determined that anxiety is common during the first year after a stroke.”
BackgroundRegush, A. (2024) · Ukrains kyi Visnyk Psykhonevrolohii · doi:10.36927/2079-0325-v32-is2-2024-11 · Cited by 1
Sorrentino, G., Everard, G. J., Vanhoof, F., Lejeune, T. M., & Edwards, M. (2025) · Smart Health · doi:10.1016/j.smhl.2025.100595 · Cited by 1
de Mendonça, J. D. A. O., de Freitas, S. H. C., de Oliveira, L. M. L., Gomes, P. C. D. S., Barbosa, L. N. F., & Bezerra, M. B. N. (2025) · Revista Psicologia e Saúde · doi:10.20435/pssa.v1i1.2999 · Cited by 1
Akpulat, H. M. G., & Avcı, Ş. (2025) · Journal of Exercise Therapy and Rehabilitation · doi:10.15437/jetr.1432655 · Cited by 1
Sonic Hedgehog Signaling: Linking in Anxiety in Murine Modeling
Wosiski‐Kuhn, M., Lullmann, O., & Luo, Y. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_15 · Cited by 1
Yusuf, M. W., Abioye, A. I., Ademola-Popoola, O., Abubakar, A. K., Olukorode, S. O., Kuyebi, M. A., Yisa, M. N., Musa, J., Oyadiran, O. T., Okusanya, T. R., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07327-9 · Cited by 1
“The prevalence estimates from Nigeria are broadly consistent with findings from other African countries and globally [41–43], underscoring the generalizability of our results.”
Jubinville, W., Bottari, C. L., Ducharme, R., Wagner, V., Thibault, G., Dugas, C., Lamontagne, M., & Roy, L. (2026) · Brain Injury · doi:10.1080/02699052.2026.2621162 · Cited by 1
“People who have sustained an ABI, particularly moderate to severe ones, may live with physical, motor, psychological, cognitive, behavioral, or language sequelae (34–39).”
童玉雪, Cao, S., Wang, J., Yuan, Q., Lin, J., Fang, Z., & Qiu, J. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1807072 · Cited by 1
Kirchhoff, C., Riedl, D., Kampling, H., Nolte, T., Kruse, J., Eke, S., Sachser, C., Fegert, J. M., Clemens, V., Brähler, E., et al. (2026) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2026.112850 · Cited by 1
Ducoffre, E., Bleyenheuft, Y., Penta, M., Somville, M., Rosselli, Z., Saussez, G., Vandermeeren, Y., & Arnould, C. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1733609 · Cited by 1
Chen, X., Fan, Y., Liu, Q., & Wang, S. Q. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1795139 · Cited by 1
Ferreira, A. P. L., & Barbosa, D. (2019) · Manual Therapy Posturology & Rehabilitation Journal · doi:10.17784/mtprehabjournal.2019.17.774 · Cited by 1
“Rafsten et al(14), in their systematic review and meta-analysis, 37 studies were found, assessing the prevalence of anxiety after the stroke episode in 13,756 patients using the HADS Scale and found that anxiety was present in 29.3% of patients during the first year after stroke.”
BackgroundInfluentialMusic Therapy in Post-Stroke Patient Anxiety Problems: Scoping Review
Mbau, E. Y. S., Handayani, F., & Kusumaningrum, N. (2020) · STRADA JURNAL ILMIAH KESEHATAN · doi:10.30994/sjik.v9i2.521 · Cited by 1
“This can occur because continued anxiety will be a predictor of depression at 6 months post stroke and problems with quality of life.(25) Meanwhile, Esra's research (2017) which used the western music group and the eastern music group resulted in a significant difference in the STAI-S score before and after listening…”
BackgroundCuratoli, C., Marcassoli, A., Guastafierro, E., Leonardi, M., Bersano, A., Boncoraglio, G. B., Canavero, I., & Raggi, A. (2023) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000605 · Cited by 1
“A proper evaluation of the psychological predictors of well-being after stroke is of relevance due to the interrelations between well-being. depression and anxiety [9,10].”
BackgroundLi, M., Yu, W., Ran, D., Yang, X., Deng, S., Shi, L., & Zhi-hong, M. (2024) · PubMed Central · doi:10.19852/j.cnki.jtcm.2024.01.001 · Cited by 1
Tiantian, W. A. N. G., Jia, Y., Qi, D., Deng, H., & Meng, D. (2024) · Rehabilitation Medicine · doi:10.3724/sp.j.1329.2024.03002 · Cited by 1
Jensen, F. G., Wienecke, T., Iversen, H. K., & Loft, M. (2025) · Aphasiology · doi:10.1080/02687038.2025.2478174 · Cited by 2
“Furthermore, stroke is associated with an increased risk of mental health issues, including depression and anxiety (Medeiros et al., 2020; Rafsten et al., 2018), and individuals with aphasia are particularly vulnerable to depression and social isolation (Sjöqvist Nätterlund, 2010; Zanella et al.,…”
Boutros, C. F., Khazaal, W., Taliani, M., Sadier, N. S., Salameh, P., & Hosseini, H. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06997-9 · Cited by 1
“Widely recognized for its validity and reliability, the HADS is among the most frequently employed tools for screening anxiety and depression post-stroke [2, 6, 43–46].”
Metadata
- Authors
- Rafsten, L., Danielsson, A., & Sunnerhagen, K.
- Affiliations
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
- Corresponding author
- Rafsten, L
- Venue
- Journal of Rehabilitation Medicine
- Published
- 2018
- Volume
- 50
- Issue
- 9
- Pages
- 769-778
- ISSN
- 1650-1977 (ISSN-L)
- OpenAlex
- W2891418975
- Cited by
- 257
- References
- 58
- Citations by year
- 2026: 17 · 2025: 38 · 2024: 53 · 2023: 36 · 2022: 40 · 2021: 36 · 2020: 24 · 2019: 9 · 2018: 2
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Rehabilitation Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- anxiety, stroke, post-stroke anxiety, prevalence, anxiety disorders, depression, quality of life, psychological screening
- MeSH terms
- Aged, Anxiety, Humans, Middle Aged, Quality of Life, Stroke
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