The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Alpha-2 Adrenergic Receptor Agonists: A Review of Current Clinical Applications
Open accessAbstract
The α-2 adrenergic receptor agonists have been used for decades to treat common medical conditions such as hypertension; attention-deficit/hyperactivity disorder; various pain and panic disorders; symptoms of opioid, benzodiazepine, and alcohol withdrawal; and cigarette craving.1 However, in more recent years, these drugs have been used as adjuncts for sedation and to reduce anesthetic requirements. This review will provide an historical perspective of this drug class, an understanding of pharmacological mechanisms, and an insight into current applications in clinical anesthesiology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073
A STUDY OF THE ADRENOTROPIC RECEPTORS
Ahlquist, R. P. (1948) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1948.153.3.586 · Cited by 2,893
Riker, R. R. (2009) · JAMA · doi:10.1001/jama.2009.56 · Cited by 1,672
Pandharipande, P. P., Pun, B. T., Herr, D. L., Maze, M., Girard, T. D., Miller, R. R., Shintani, A. K., Thompson, J. L., Jackson, J. C., Deppen, S. A., et al. (2007) · JAMA · doi:10.1001/jama.298.22.2644 · Cited by 1,451
The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans
Ebert, T. J., Hall, J. E., Barney, J. A., Uhrich, T. D., & Colinco, M. D. (2000) · Anesthesiology · doi:10.1097/00000542-200008000-00016 · Cited by 1,388
Dexmedetomidine: A Novel Sedative-Analgesic Agent
Gertler, R., Brown, H. C., Mitchell, D. H., & Silvius, E. N. (2001) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2001.11927725 · Cited by 856
PATON, W. D. M., & VIZI, E. S. (1969) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1969.tb07964.x · Cited by 704
Virtanen, R., Savola, J.-M., Saano, V., & Nyman, L. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90744-3 · Cited by 701
Venn, R. M., & Grounds, R. M. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.5.684 · Cited by 383
Subtypes of α 1 ‐ and α 2 ‐adrenergic receptors
Bylund, D. B. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.3.1346768 · Cited by 364
Cited by
Management of Musculoskeletal Pain: An Update with Emphasis on Chronic Musculoskeletal Pain
El-Tallawy, S. N., Nalamasu, R., Salem, G. I., LeQuang, J. A. K., Pergolizzi, J. V., & Christo, P. J. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00235-2 · Cited by 532
Skvarc, D. R., Berk, M., Byrne, L. K., Dean, O. M., Dodd, S., Lewis, M., Marriott, A., Moore, E. M., Morris, G., Page, R. S., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.011 · Cited by 312
Common brain mechanisms of chronic pain and addiction
Elman, I., & Borsook, D. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.027 · Cited by 303
Kumar, K., Kirksey, M. A., Duong, S., & Wu, C. L. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002497 · Cited by 308
Evidence-based pharmacological treatment options for ADHD in children and adolescents
Mechler, K., Banaschewski, T., Hohmann, S., & Häge, A. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107940 · Cited by 293
Metadata
- Authors
- Giovannitti, J. A., Thoms, S. M., & Crawford, J. J.
- Venue
- Anesthesia Progress
- Published
- 2015
- Volume
- 62
- Issue
- 1
- Pages
- 31-38
- ISSN
- 0003-3006 (ISSN-L)
- 1878-7177
- OpenAlex
- W2101795926
- Cited by
- 622
- References
- 22
- FWCI
- 28.57
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Alpha-2 Adrenergic Receptor Agonists: A Review of Current Clinical Applications. https://app.cochat.ai/papers/10.2344/0003-3006-62.1.31
- The paper
- Giovannitti, J. A., Thoms, S. M., & Crawford, J. J. (2015). Alpha-2 Adrenergic Receptor Agonists: A Review of Current Clinical Applications. Anesthesia Progress. https://doi.org/10.2344/0003-3006-62.1.31
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.