Cited by 39Antibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsAntimicrobial agents and applications

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Increasing antibiotic resistance in preservative-tolerant bacterial strains isolated from cosmetic products

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Orús·2015·PubMed

DOI 10.2436/20.1501.01.234

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Abstract

To ensure the microbiological quality, consumer safety and organoleptic properties of cosmetic products, manufacturers need to comply with defined standards using several preservatives and disinfectants. A drawback regarding the use of these preservatives is the possibility of generating cross-insusceptibility to other disinfectants or preservatives, as well as cross resistance to antibiotics. Therefore, the objective of this study was to understand the adaptive mechanisms of Enterobacter gergoviae, Pseudomonas putida and Burkholderia cepacia that are involved in recurrent contamination in cosmetic products containing preservatives. Diminished susceptibility to formaldehyde-donors was detected in isolates but not to other preservatives commonly used in the cosmetics industry, although increasing resistance to different antibiotics (β-lactams, quinolones, rifampicin, and tetracycline) was demonstrated in these strains when compared with the wild-type strain. The outer membrane protein modifications and efflux mechanism activities responsible for the resistance trait were evaluated. The development of antibiotic-resistant microorganisms due to the selective pressure from preservatives included in cosmetic products could be a risk for the emergence and spread of bacterial resistance in the environment. Nevertheless, the large contribution of disinfection and preservation cannot be denied in cosmetic products.

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BackgroundMethodInfluentialSelf-citation
Isolation and Identification of Microorganisms associated with high-quality and low-quality cosmetics from different brands in Mecca region -Saudi Arabia
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BackgroundInfluential
Preservative Sensitization—Safety With and Safety Without
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Santana, M. T. P., Gomes, L. L., dos Santos, T. A., et al. (2020) · ARCHIVES OF HEALTH INVESTIGATION · doi:10.21270/archi.v9i4.5034 · Cited by 1
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de Lira, M. F., de Melo, B. M. T., de Oliveira, L. L., Bezerra, C. D. O., Coutinho, F. N., & de Faria, A. R. (2020) · Latin American Publicações eBooks · doi:10.47174/lap2020.ed.0000017
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Authors: Orús
Venue: PubMed
Publisher: National Institutes of Health
Published: 2015-03-01
Volume: 18
Issue: 1
Pages: 51-9
DOI: 10.2436/20.1501.01.234
OpenAlex: W2191592077
Cited by: 39
References: 0
Citations by year: 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 19 · 2018: 1 · 2017: 3 · 2016: 1
FWCI: 0.69
Type: journal article
Language: en
Open access: green
revistes.iec.cat
Locations: PubMed (publishedVersion)
Estudis Romànics (Institut d'Estudis Catalans) (submittedVersion)
PubMed
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Keywords: antibiotic resistance, cosmetics, preservatives, cross-resistance, Enterobacter gergoviae, Pseudomonas putida, Burkholderia cepacia, outer membrane proteins, efflux pumps, disinfectants, beta-lactam antibiotics, quinolones, tetracycline, rifampicin, microbial contamination
MeSH terms: Anti-Bacterial Agents, Cosmetics, Enterobacter, Humans, Microbial Sensitivity Tests, Preservatives, Pharmaceutical, Pseudomonas, Burkholderia, Drug Resistance, Bacterial

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Increasing antibiotic resistance in preservative-tolerant bacterial strains isolated from cosmetic products

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