Blood oxygen binding in double-muscled calves and dairy calves with conventional muscle conformation
Open accessAbstract
OBJECTIVE: To assess in vivo blood oxygen binding in double-muscled calves and dairy calves with conventional muscle conformation. ANIMALS: 58 dairy and 48 double-muscled calves. PROCEDURE: Calves were classified as neonatal (24 hours old) or older calves (2 to 26 days old). Venous and arterial blood samples were collected, and hemoglobin concentration, pH, PCO2, and PO2 were determined. Blood oxygen equilibrium curves (OEC) under standard conditions were constructed, and the oxygen exchange fraction (OEF) and the amount of oxygen released at the tissue level by 100 ml of blood (OEF Vol%) were calculated. RESULTS: In each breed, partial pressure of oxygen at 50% saturation of hemoglobin (P50) under standard conditions was significantly higher in older than in neonatal calves, indicating a right shift in OEC with age. Venous P50 was significantly lower in neonatal double-muscled calves than in neonatal dairy calves, but arterial and venous P50 were significantly higher in older double-muscled calves than in older dairy calves. In double-muscled, but not in dairy, calves, OEF was significantly higher in older than in neonatal calves. In neonatal calves, OEF Vol% was not significantly different between breeds, but OEF Vol% was significantly higher in older double-muscled calves than in older dairy calves. CONCLUSIONS AND CLINICAL RELEVANCE: The lower OEF in neonatal double-muscled calves, compared with dairy calves, could contribute to the higher sensitivity of double-muscled calves to hypoxia. Blood oxygen affinity decreased with age, but OEF and OEF Vol% were unchanged with age in dairy calves, whereas they increased with age in double-muscled calves.
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pH increases during the first month of life to reach standard adult values.
“pH increases during the first month of life to reach standard adult values”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Cambier et al., 2000
The Results and Table 1 report lower arterial and venous pH in older double-muscled calves than in neonatal calves; both measures decreased rather than increased. The paper does not report pH reaching adult values during the first month of life. (LLM, conf=0.90)
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Cites
Modern quantitative acid–base chemistry
Stewart, P. A. (1983) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y83-207 · Cited by 1,397 · see citing works
Reeves, R. B. (1972) · Respiration Physiology · doi:10.1016/0034-5687(72)90030-8 · Cited by 392 · see citing works
A simplified strong ion model for acid-base equilibria: application to horse plasma
Constable, P. D. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.297 · Cited by 183 · see citing works
Clerbaux, T., Gustin, P., Detry, B., et al. (1993) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(93)90382-e · Cited by 91 · see citing works
Self-citationPulmonary function values and growth in Belgian white and blue double-muscled cattle
Gustin, P., Bakima, M., Art, T., et al. (1988) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)30974-3 · Cited by 36 · see citing works
Self-citationInfluence of age and breed on the binding of oxygen to red blood cells of bovine calves
Gustin, P., Detry, B., Robert, A., Cao, M. L., Lessire, F., Cambier, C., Katz, V., Ansay, M., Frans, A., & Clerbaux, T. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.3.784 · Cited by 27 · see citing works
Self-citationChloride and inorganic phosphate modulate binding of oxygen to bovine red blood cells
Gustin, P., Detry, B., Cao, M. L., et al. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.1.202 · Cited by 25 · see citing works
Self-citationOxygen transport properties of blood in two different bovine breeds
Gustin, P., Clerbaux, T., Willems, E., et al. (1988) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(88)90832-8 · Cited by 24 · see citing works
Self-citationClerbaux, T., Fesler, R., & Bourgeois, J. (1973) · PubMed · Cited by 23 · see citing works
Self-citationOxygen transport chain in double-muscled blue belgian cattle
Lekeux, P. M., Amory, H., Desmecht, D. J.-M., et al. (1994) · British Veterinary Journal · doi:10.1016/s0007-1935(05)80197-6 · Cited by 18 · see citing works
Cardio-pulmonary function values in double-muscled cattle during muscular exercise
Gustin, P., Dhem, A. R., Lomba, F., et al. (1988) · Veterinary Research Communications · doi:10.1007/bf00343261 · Cited by 18 · see citing works
Self-citationInteraction of organic phosphates with bovine hemoglobin
Breepoel, P. M., Kreuzer, F., & Hazevoet, M. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584783 · Cited by 18 · see citing works
Postnatal Loss of Bovine Fetal Hemoglobin
Lee, C. K., Odell, G. V., Eliot, F. P., et al. (1971) · American Journal of Veterinary Research · doi:10.2460/ajvr.1971.32.07.1039 · Cited by 18 · see citing works
McGillivray, Gp, S., & Vm, H. (1985) · PubMed · Cited by 14 · see citing works
Developmental Polymorphism in Bovine Hemoglobin
Hubbert, W. T., & Miller, W. J. (1971) · American Journal of Veterinary Research · doi:10.2460/ajvr.1971.32.11.1723 · Cited by 14 · see citing works
Amory, H., Desmecht, D. J.-M., Linden, A. S., et al. (1994) · American Journal of Veterinary Research · doi:10.2460/ajvr.1994.55.04.561 · Cited by 9 · see citing works
The Pattern of Disappearance of Foetal Haemoglobin in Young Calves
Tisdall, M., & Crowley, J. P. (1971) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)34115-8 · Cited by 5 · see citing works
Pulmonary Function Values in Friesian and Double‐Muscled Calves during Acute Poikilocapnic Hypoxia
Rollin, F. G., Amory, H., Desmecht, D. J.-M., et al. (1997) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1997.tb01089.x · Cited by 2 · see citing works
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Research works printed but not linked: 1
- Gustin P, Dhem A, Lomba F, et al. Cardiopulmonary func- tion values in double-muscled cattle during muscular exercise. Vet Res Commun 1988;12:407-416.
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Establishing blood gas ranges in healthy bovine neonates differentiated by age, sex, and breed type
Dillane, P., Krump, L., Kennedy, A., Sayers, R. G., & Sayers, G. P. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13445 · Cited by 65 · see citing works
Goetz, H. M., Creutzinger, K. C., Kelton, D. F., Costa, J. H. C., Winder, C. B., Gomez, D. E., & Renaud, D. L. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22367 · Cited by 20 · see citing works
- Authors
- Cambier, C., Clerbaux, T., Detry, B., Beerens, D., Frans, A., & Gustin, P.
- Affiliations
- Cliniques Universitaires Saint-Luc (BE)
- Venue
- American Journal of Veterinary Research
- Published
- 2000-03-01
- Volume
- 61
- Issue
- 3
- Pages
- 299-304
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W2154679740
- Cited by
- 19
- References
- 18
- Citations by year
- 2023: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- dairy calves, oxygen equilibrium curve, P50, hypoxia sensitivity, neonatal calves, age-related changes, hemoglobin oxygen affinity
- MeSH terms
- Adenosine Triphosphate, Age Factors, Animals, Animals, Newborn, Blood Gas Analysis, Body Temperature, Cattle, Female, Hemoglobins, Hydrogen-Ion Concentration, Male, Oxygen, Phosphates, Regression Analysis, Muscle, Skeletal, 2,3-Diphosphoglycerate
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