The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Sesquiterpenes α-humulene and β-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells
Open accessAbstract
The present study is designed to find out if sesquiterpenes, α-humulene (HUM), valencene (VAL), β-caryphyllene-oxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexaneoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. In addition, the possible mechanisms of sesquiterpene action are studied. The results show significant ability of HUM and especially of CAO to enhance the anti-proliferative effects of FU and OxPt in cancer cell lines Caco-2 and SW-620. On the other hand, VAL and NER are ineffective. The action of CAO could be partly based on its ability to disrupt the mitochondrial membrane potential and to activate initiator caspases, but other mechanisms are probably also involved. Based on these results, CAO seems to have the potential for combination therapy of colon cancers and deserves further study.
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“This compound has shown anti-inflammatory and antitumor activity in lung, colon, prostate, and breast cancer.”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [42]
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“It can also improve the antiproliferative effect of cytostatic drugs and other anticancer bioactivities [42,44].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [42]
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“Some studies reported that α-humulene demonstrated antiproliferative activity and alteration of the mitochondrial cell membrane in colon cancer cells [14,37,42,43,44,45,46].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [42]
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Cites
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Antioxidant, Pro-Oxidant and Other Biological Activities of Sesquiterpenes
Bártíková, H., Hanušová, V., Skálová, L., et al. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026614666141203120833 · Cited by 111
Self-citationRasul, A., Bao, R., Malhi, M., Zhao, B. Q., Tsuji, I., Li, J., & Li, X. (2013) · Molecules · doi:10.3390/molecules18021418 · Cited by 106
Ambrož, M., Boušová, I., Skarka, A., Hanušová, V., Králová, V., Matoušková, P., Szotáková, B., & Skálová, L. (2015) · Molecules · doi:10.3390/molecules200815343 · Cited by 80
Self-citationKim, C., Cho, S. K., Kim, K.-D., Nam, D., Chung, W., Jang, H.-J., Lee, S., Shim, B. S., Sethi, G., & Ahn, K. S. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0957-9 · Cited by 73
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Langhasova, L., Hanusova, V., Rezek, J., Stohanslova, B., Ambroz, M., Kralova, V., Vanek, T., Lou, J. D., Yun, Z. L., Yang, J., et al. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.04.018 · Cited by 46
Ambrož, M., Matoušková, P., Skarka, A., Zajdlová, M., Žáková, K., & Skálová, L. (2017) · Molecules · doi:10.3390/molecules22061021 · Cited by 43
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Haro-González, J. N., Castillo-Herrera, G. A., Martínez-Velázquez, M., & Espinosa-Andrews, H. (2021) · Molecules · doi:10.3390/molecules26216387 · Cited by 463
Metadata
- Authors
- Ambrož, M., Šmatová, M., Šadibolová, M., Pospíšilová, E., Hadravská, P., Kašparová, M., Skarková, V. H., Králová, V., & Skálová, L.
- Affiliations
- Charles University (CZ)
- Corresponding author
- Skálová, Lenka
- ORCID
- Venue
- Acta Pharmaceutica
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018-12-07
- Volume
- 69
- Issue
- 1
- Pages
- 121-128
- ISSN
- 1330-0075 (ISSN-L)
- 1846-9558
- OpenAlex
- W2905047533
- Cited by
- 52
- References
- 13
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Zagreb University Computing Centre (SRCE) (submittedVersion, other-oa)
- Funders
- Univerzita Karlova v Praze (SVV260416, P303/12/G163)
- Grantová Agentura České Republiky (GBP303/12/G163)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacological Effects of Medicinal Plants
- Keywords
- sesquiterpenes, α-humulene, caryophyllene oxide, valencene, trans-nerolidol, 5-fluorouracil, oxaliplatin, colon cancer, combination chemotherapy, antiproliferative activity, mitochondrial membrane potential, caspase activation, Caco-2 cells, SW620 cells
- MeSH terms
- Oxaliplatin, Monocyclic Sesquiterpenes, Polycyclic Sesquiterpenes, Colonic Neoplasms, Fluorouracil, Humans, Sesquiterpenes, Caco-2 Cells, Cell Line, Tumor, Cell Proliferation, Membrane Potential, Mitochondrial
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