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Cited by 46Essential Oils and Antimicrobial ActivityMedicinal Plant ResearchInsect Pest Control Strategies

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines

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Langhasova, Lenka, Hanusova, Veronika, Rezek, Jan, Stohanslova, Barbora, Ambroz, Martin, Kralova, Vera, Vanek, Tomas, Lou, Ji Dong, Yun, Zhu Li, Yang, Jun, Skalova, Lenka·2014·Industrial Crops and Products
DOI 10.1016/j.indcrop.2014.04.018
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Abstract

The leaves of Myrica rubra (Sieb. et Zucc), a subtropical Asian fruit tree with traditional use in folk medicines, were extracted by hydrodistillation. The antiproliferative effect of obtained M. rubra essential oil (MEO) was tested in human colon and ileocecal adenocarcinoma cell lines HCT8, SW620, SW480, HT29 and Caco2. Cytostatic drug paclitaxel was used as a positive control. MEO significantly inhibited cell proliferation in concentration-dependant manner in all cell lines. The efficacy of MEO differed in individual cell lines, with Caco2 being the most sensitive. In these cells, MEO IC50 value of 1.5μg/mL was obtained using xCelligence system for real-time cell monitoring. In cancer cells, MEO induces apoptosis and caused significant increase of activities of initiator as well as effector caspases. Contrary to cancer cells, MEO did not affect viability of isolated hepatocytes (as a model of normal non-cancerous cells). GC×GC-TOFMS analysis of MEO chemical composition revealed β-caryophyllene, α-humulene, humulene epoxide I, valencene, epi-α-selinene, γ-muurolene, β-caryphyllene-oxide, and trans-nerolidol as dominant compounds.

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Research works printed but not linked: 2

  1. El Hadri, 2010, Cytotoxic activity of alpha-humulene and trans-caryophyllene from Salvia officinalis in animal and human tumor cells, An. Real. Acad. Nac. Farm., 76, 343
  2. Keawsa-ard, 2012, Antioxidant, antibacterial, anticancer activities and chemical constituents of the essential oil from Mesua ferrea leaves, Chiang Mai J. Sci., 39, 455

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Metadata

Authors
Langhasova, L., Hanusova, V., Rezek, J., Stohanslova, B., Ambroz, M., Kralova, V., Vanek, T., Lou, J. D., Yun, Z. L., Yang, J., & Skalova, L.
Affiliations
  • Czech Academy of Sciences (CZ)
  • China Jiliang University (CN)
  • China Tobacco (CN)
ORCID
Venue
Industrial Crops and Products
Publisher
Elsevier BV
Published
2014-08
Volume
59
Pages
20-26
ISSN
0926-6690 (ISSN-L)
DOI
10.1016/j.indcrop.2014.04.018
OpenAlex
W2086836946
Cited by
46
References
26
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 2
FWCI
4.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Industrial Crops and Products (publishedVersion)
  • ASEP (submittedVersion, public-domain)
Funders
  • Ministry of Education Youth, and Sports of the Czech Republic
  • Prague
  • Czech Science Foundation with the project Center of Excellence
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Keywords
Myrica rubra, essential oils, leaf essential oil, colon cancer, antiproliferative activity, apoptosis, caspase activation, Caco-2 cells, β-caryophyllene, essential oil composition, hepatotoxicity, anticancer natural products

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The paper
Langhasova, L., Hanusova, V., Rezek, J., Stohanslova, B., Ambroz, M., Kralova, V., Vanek, T., Lou, J. D., Yun, Z. L., Yang, J., & Skalova, L. (2014). Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines. Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2014.04.018