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Synthesizing cysteine-coated magnetite nanoparticles as MRI contrast agent: Effect of pH and cysteine addition on particles size distribution
Abstract
Cysteine capped magnetite nanoparticles (10 to 20 nm) were synthesized via coprecipitation method under ultrasonic irradiation. The influence of pH value of the solution and cysteine addition on the size distribution and hydrodynamic size of nanoparticles were studied via TEM and PCS methods, respectively. The crystal structure and magnetic properties of the nanoparticles were characterized by XRD and VSM techniques, respectively. Coating density was calculated using TGA and TEM results. Cytotoxicity assessment performed by incubation of L929 cells, confirmed that ferrofluids are biocompatible. MRI studies conducted on rats demonstrated suitability of synthesized nanoparticles as contrast agents, especially for imaging of the lymph nodes.
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Prototypic examples of materials used to coat iron oxide nanoparticles are polymers, fatty acids, amino acids, metals, and oxides.
“Prototypic examples of materials used to coat iron oxide nanoparticles are polymers [28, 47, 50], fatty acids (like oleic acid, stearic acid, lauric acid and dodecylphosphonic acid) [51–55], amino acids (like phenyl alanine, tyrosine, arginine, lysine and cysteine) [56–58],_metals (like gold, gadolinium and silver) [59–61] and oxides (like silica and TiO2) [62–64].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [57]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Metadata
- Authors
- Ahmadi, R., Ranjbarnodeh, E., & Gu, N.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Islamic Azad University, Tehran (IR)
- Corresponding author
- Ahmadi, R.
- Venue
- Materials Science-Poland
- Publisher
- Walter de Gruyter GmbH
- Published
- 2012-10-24
- Volume
- 30
- Issue
- 4
- Pages
- 382-389
- ISSN
- 0137-1339 (ISSN-L)
- 2083-1331
- OpenAlex
- W1999473860
- Cited by
- 11
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Materials Science-Poland (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Physical Sciences › Earth and Planetary Sciences › Geophysics › Geomagnetism and Paleomagnetism Studies
- Keywords
- Fe3O4 nanoparticles, MRI contrast agents, ferrofluids, co-precipitation synthesis, sonication, pH effect, particle size distribution, hydrodynamic diameter, coating density, biocompatibility, cytotoxicity, lymph node imaging
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