CoChat
Sign Up
Cited by 154Phytoestrogen effects and researchPhytochemicals and Antioxidant ActivitiesBioactive natural compounds

Isoflavonoids — an overview of their biological activities and potential health benefits

Open access
Miadoková, Eva·2009·Interdisciplinary Toxicology
DOI 10.2478/v10102-009-0021-3PMC PMC2984117
Open this paper in CoChat — free accountOpen PDF

Abstract

Isoflavonoids — an overview of their biological activities and potential health benefits: There are many biological activities attributed to isoflavonoids. The majority of them could be beneficial and some of them may be detrimental, depending on specific circumstances. Isoflavonoids play an important role in human nutrition as health promoting natural chemicals. They belong to plant secondary metabolites that mediate diverse biological functions through numerous pathways. They are structurally similar to estrogens, exerting both estrogenic and antiestrogenic properties in various tissues. The results of epidemiologic studies exploring the role of isoflavonoids in human health have been inconclusive. Some studies support the notion of a protective effect of their consumption in immunomodulation, cognition, risk reduction of certain cancers, cardiovascular and skin diseases, osteoporosis and obesity, as well as relief of menopausal symptoms. Other studies failed to demonstrate any effects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2478/v10102-009-0021-3

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Isoflavonoids are dietary antioxidants that may protect against oxidative stress connected to inflammation and damaging the macromolecule by free radicals and other oxygen and nitrogen oxidizers.

    “Isoflavonoids are dietary antioxidants that may protect against oxidative stress connected to inflammation and damaging the macromolecule by free radicals and other oxygen and nitrogen oxidizers (Miadoková 2009).”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Miadoková 2009

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 54

  1. Akhter M Inoue M Kurahashi N Iwasaki M Sasazuki S Tsugane S Dietary soy isoflavone intake and risk of colorectal cancer in the Japan Public Health Cancer–based prospective study Epidem Biomark Prev 2008 17 8 2128 2135 18708407
  2. Atkinson C Warren RM Sala E Dowsett M Dunning AM Healey CS Runswick S Day NE Bingham SA Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial Breast Can Res 2004 6 3 170 179 PMC400670 15084240
  3. Barnes S Soy isoflavones – phytoestrogens and what else? J Nut 2004 134 1225S 1228S 15113976
  4. Bezek S Ujhazy E Mach M Navarova J Dubovicky M Developmental origin of chronic diseases: toxicological implication Interdisc Toxicol 2008 1 1 29 31 PMC2993479 21218103
  5. Birt DF Hendrich S Wang W Dietary agents in cancer prevention: flavonoids and isoflavonoids Pharmacol Ther 2001 90 2–3 157 177 11578656
  6. Cesarone MR Grossi MG Di Renzo A Errich S Schönlau F Wilmer JL Lange M Blimenfeld J Accelerated antioxidant bioavailability of OPC-3® bioflavonoids administered as isotonic solution Phytother Res 2009 23 6 775 777 19172583
  7. Chen Y Gammon MD Teitelbaum SL Britton JA Terry MB Shantakumar S Eng SM Wang Q Gurvich I Neugut AI Santella RM Ahsan H Estrogen-biosynthesis gene CYP17 and its interactions with reproductive hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project Carcinogen 2008 29 4 766 771 18281250
  8. Cherdshewasart W Sutjit W Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria libata tubers Phytomed 2008 15 1–2 38 43 17890070
  9. Chodon D Ramamurty N Sakthisekan D Inhibition of cell proliferation and induction of apoptosis by genistein in hepatocellular carcinoma Tox in Vitro 2007 20 5 887 891 17391909
  10. Chrzan BG Bradford PG Phytoestrogens activate estrogen receptor β1 and estrogenic responses in human breast and bone cancer cell lines Mol Nutr Food Res 2007 51 171 177 17266178
  11. Dixon RA Summer LW Legume natural products: Understanding and manipulating complex pathways for human and animal health Plant Physiol 2003 131 878 885 12644640 PMC1540287
  12. Duffy C Perez K Partridge A Implications of phytoestrogen intake for breast cancer CA Can J Clin 2007 57 260 277 17855484
  13. Eliassen AH Missmer SA Tworoger SS Hankinson SE Circulating 2-hydroxy and 16ɑ-hydroxy estrone levels and risk of breast cancer among postmenopausal women Can Epidem Biomark Prev 2008 17 8 2029 2035 PMC2562592 18708395
  14. Fink BN Steck SE Wolff MS Britton JA Kabat GC Gaudet MM Abrahamson PE Bell P Schroeder JC Teiltelbaum SL Neugut AI Gammon MD Dietary flavonoid intake and breast cancer survival among women on Long Island Can Epidem Biomark Prev 2007 16 11 2285 2292 18006917
  15. Goodman MT Shvetsov YB Wilkens LR Franke AA Marchand LL Kazaku KK Nomura AMY Henderson BE Kolonel LN Urinary phytoestrogen excretion and postmenopausal breast cancer risk: the multiethnic cohort study Can Prev Res 2009 2 887 PMC2920130 19789300
  16. Hirschberg AL Edlund M Svane G Azavedo E Skoog L von Schoultz B An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women Menopause 2007 14 1 89 96 17019374
  17. Hedlund TE van Bokhaven A Johannes WU Nordeen SK Ogden LG Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant epithelial cells in vitro The Prost 2005 66 5 557 566 16372328
  18. Ito C Murata T Itoigawa M Nakao K Kumagai M Kaneda N Furukawa H Induction of apoptosis by isoflavonoids from leaves of Milletia taiwaniana in human leukemia HL-60 cells Planta Med 2006 72 5 424 429 16557456
  19. Iwasaki M Inoue M Otani T Sasazuki S Kurashi N Miura T Yamoto S Tsugane S Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from Japan Public Health Center-base prospective study group J Clin Oncol 2008 26 10 1677 1683 18316793
  20. Ju IH Allred KF Allred CD Helferich WG Genistein stimulates growth of human breast cancer cells in a novel postmenopausal animal model, with low plasma estradiol concentrations Carcinogen 2006 27 1292 1299 16537557
  21. Kousidou OC Tzanakakis GN Karamanos NK Effects of natural isoflavonoid genistein on growth, signaling pathway and gene expression of matrix macromolecules by breast cancer cells Mini Rev Med Chem 2006 6 3 331 337 16515472
  22. Kralova J Pekarova M Drabikova K Jancinova V Nosal R Ciz M Lojek A The effects of dithiaden on nitric oxide production by RAW 264.7 cells Interdisc Toxicol 2008 1 3–4 214 217 PMC2994028 21218118
  23. Lampe JW Is equol the key to the efficacy of soy foods? Am J Clin Nutr 2009 89 1664S 1667S 19357217 PMC2677009
  24. Liu B Edgerton S Yang X Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention Can Res 2005 65 879 886 15705886
  25. Maskarinec G Williams AE Carlin L Mammographic densities in a one-year isoflavone intervention Eur J Can Prev 2003 12 2 165 169 12671541
  26. Maskarinec G Hebshi S Custer L Franke AA The relation of soy intake and isoflavone levels in nipple aspirate fluid Eu J Can Prev 2008a 17 1 67 70 18090913
  27. Maskarinec G Watts K Kagihara J Hebshi SM Franke AA Urinary isoflavonoid is similar after consuming soya milk and miso soup in Japanese-American women Brit J Nutr 2008b 100 424 429 18275624 PMC2706912
  28. Maskarinec G Verheus M Steinberg FM Amato P Cramer M Lewis RD Murray MJ Yong RL Wong WW Various doses of isoflavones do not modify mammographic density in postmenopausal women J Nutr 2009 139 5 981 986 19321587 PMC2714394
  29. Messina M Wood CE Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary Nutr J 2008 7 1 17 28 18522734 PMC2443803
  30. Messina M McCaskill-Stevens W Lampe JW Addressing the soy and breast cancer relatioship: review, commentary, and workshop proceedings J Natl Can Inst 2006 98 18 1275 1284 16985246
  31. Miadokova E Masterova I Vlckova V Duhova V Toth J Antimutagenic potential of homoisoflavonoids from Muscari racemosum J Ethnopharmacol 2002 18 381 386 12127240
  32. Murata IC Itoigawa M Nakao K Kumagai M Kaneda N Furukawa H Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells Planta Med 2006 72 5 424 429 16557456
  33. Nagata C Nakamura K Fujii K Kawachi T Takatsuka N Oba S Shimizu H Soy isoflavone intake is not associated with the development od cedar pollinosis in adults J Nutr 2008 138 1372 1376 18567763
  34. Ørgaard A Jensen L The effects of soy isoflavones on obesity Exp Biol Med 2008 233 1066 1080 18535167
  35. Perry DL Spedick JM McCoy TP Adams MR Franke AA Cline JM Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis) J Nutr 2007 137 1390 1394 17513396
  36. Piller R Chang-Claude J Linseisen J Plasma enterolactone and genistein and the risk of premenopausal breast cancer Eu J Can Prev 2006 15 3 225 232 16679865
  37. Raju J Bielecki A Caldwell D Lok E Taylor M Kapal K Curran I Cooke GM Bird RP Mehta R Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells increasing the expression of estrogen receptor beta Nutr 2009 139 3 474 4781 19141699
  38. Ralston L Subramanian S Matsuto M Yu O Partial reconstruction of flavoid and soflavoid biosynthesis in yeast using soybean Type I and Type II chalcone isomerases Plant Physiol 2005 137 4 1375 1388 15778463 PMC1088328
  39. Reiter RJ Paredes SD Kormaz A Jou M-J Tan D-X Melatonin combats molecular terrorism at the mitochondrial level Interdisc Toxicol 2008 1 2 137 149 PMC2993480 21218104
  40. Rice S Mason HD Whitehead SA Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells J Ster Biochem Mol Biol 2006 101 4–5 216 225 16965912
  41. Ryan-Borchers TA Park JS Chew BP McGuire MK Fournier LR Beerman KA Soy isoflavones modulate immune function in healthy postmenopausal women Am J Clin Nutr 2006 83 118 1125 16685055
  42. Sabudak T Guler N Trifolium L.- A review on its phytochemical and pharmacological profile Phytother Res 2009 23 439 446 19107737
  43. Shen P Liu MH Ng TY Chan YH Long EL Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPAR gamma, and adipocyte differentiation in vitro J Nutr 2006 136 899 905 16549448
  44. Scarpato R Paganucci L Bertoli A Fiore L Pistelli L Federico G Licoflavone C attenuates the genotoxicity of cancer drugs in human peripheral lymphocytes Phytother Res 2008 22 12 1650 1654 18979523
  45. Shen P Liu MH Ng TY Chan YH Yong EL Differential effects of isoflavones, from Astragalus membranaceus and Puerarua thomsonii, on the activation of PPARalpha, PPAR gamma, and adipocyte differentiation in vitro J Nutr 2006 136 899 905 16549448
  46. Su Y Simmen RCM Soy isoflavone genistein upregulates epithelian adhesion molecule E-cadherin expression and β-catenin signaling in mammary epithelial cells Carcinogen 2009 30 2 331 339 19073877
  47. Talbott KE Gammon MD Kibriva MG Chen Y Teilbaum SL Long CM Gurvich I Santella RM Ahsan H A Cyp 19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk Breast Can Res Treat 2008 111 3 481 487 17975727
  48. Tamini RM Hankinson SE Coldiz GA Byrne C Endogenous sex hormone levels and mammographic density among postmenopausal women Can Epidem Biomark Prev 2005 14 2641 2647 16284390
  49. Thorp AA Howe PR Mori TA Coates AM Buckley JD Hodgson J Mansour J Meyer BJ Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers Am J Clin Nutr 2008 88 2 298 304 18689364
  50. Verheus M van Gils CH Kreijkamp-Kaspers S Kok L Peeters PH Grobbee DE van der Schouw YT Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women Can Epidem Biomark Prev 2008 17 10 2632 2638 18843004
  51. Wang Y Gho WM Chan FL Chen S Leung LK The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression Brit J Nutr 2008 99 303 310 17761019
  52. Wood CE Appt S Clarkson TB Franke AA Lees C Doerge DR Cline JM Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys Biol Rep 2006 75 3 477 486 16723506
  53. Wood CE Register TC Cline JM Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys Carcinogen 2007 28 4 801 808 17032659
  54. Widyarini S Domanski D Painter N Reeve VE Estrogen receptor signaling protects against immune suppression by UV radiation exposure Proc Nat Acad Sci 2006 103 34 12837 12842 16908847 PMC1568934

Cited by

Sorted by citations

Authors
Miadoková, E.
Affiliations
Comenius University Bratislava (SK)
Corresponding author
Miadoková, Eva
Venue
Interdisciplinary Toxicology
Publisher
Walter de Gruyter GmbH
Published
2009-12-01
Volume
2
Issue
4
Pages
211-218
ISSN
  • 1337-6853 (ISSN-L)
  • 1337-9569
DOI
10.2478/v10102-009-0021-3
PMC
PMC2984117
OpenAlex
W2129309205
Cited by
154
References
1
Citations by year
2026: 5 · 2025: 25 · 2024: 13 · 2023: 26 · 2022: 20 · 2021: 12 · 2020: 19 · 2019: 10 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
0.94
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Interdisciplinary Toxicology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
isoflavonoids, phytoestrogens, estrogenic activity, antiestrogenic activity, plant secondary metabolites, health benefits, cancer risk reduction, cardiovascular disease, osteoporosis, obesity, menopausal symptoms, immunomodulation, cognitive function, skin diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review