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Malignant Mesothelioma: A Clinical Study of 238 Cases
Open accessAbstract
Malignant mesothelioma is a diffuse tumor arising in the pleura, peritoneum, or other serosal surface and is closely associated with asbestos exposure. An estimated 2,500 to 3,000 cases are diagnosed each year in the United States. Although there are individual case reports and small series detailing the clinical aspects of mesothelioma, few studies examine a large series of patients with malignant mesothelioma from the clinical perspective. This study reports on the findings of 238 cases of malignant mesothelioma from a private consultative medical practice. Most cases had a history of occupational asbestos exposure. The mean latency was 48.5 yr, with women having a longer latency than men. The mean age at diagnosis was 70. Survival overall was poor (mean 8.8 months), but treatment was beneficial (mean 11.3 versus 6.4 months). Epithelioid histology conferred a survival advantage over sarcomatoid and responded better to treatment. Our data support an inverse relationship between asbestos dose and latency.
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“The association between sex and mesothelioma has not been consistent in the literature ( Metintas et al , 1999 ; Hyland et al , 2007 ; Haber and Haber, 2011 ).”
From The latency period of mesothelioma among a cohort of British asbestos workers (1978–2005) (2013) · cites this paper as Haber and Haber, 2011
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“Haber and Haber (2011) found that women had longer latencies than men, and attributed this to women tending to have lower exposures than men due to their mainly non-occupational asbestos exposure.”
From The latency period of mesothelioma among a cohort of British asbestos workers (1978–2005) (2013) · cites this paper as Haber and Haber, 2011
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Cited by
Sorted by citations
The latency period of mesothelioma among a cohort of British asbestos workers (1978–2005)
Frost, G. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.514 · Cited by 109
“Differences in mesothelioma latency that have been observed—for example, differences by occupation (Bianchi et al, 1997), sex (Haber and Haber, 2011), and source of exposure (Marinaccio et al, 2007)—are often attributed to differences in the intensity of exposure to asbestos.”
BackgroundResultInfluential
Metadata
- Authors
- HABER, S. E., & HABER, J. M.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- ORCID
- HABER, Jason M.
- Venue
- Industrial Health
- Published
- 2011
- Volume
- 49
- Issue
- 2
- Pages
- 166-172
- ISSN
- 0019-8366 (ISSN-L)
- 1880-8026
- OpenAlex
- W2105563627
- Cited by
- 45
- References
- 46
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 3
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Industrial Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Social Sciences › Health › Occupational Health and Global Justice
- Keywords
- malignant mesothelioma, asbestos exposure, occupational exposure, latency, survival, epithelioid histology, sarcomatoid histology, pleural mesothelioma, peritoneal mesothelioma, sex differences
- MeSH terms
- Adult, Aged, Aged, 80 and over, Environmental Exposure, Female, Humans, Male, Mesothelioma, Middle Aged, Occupational Diseases, Peritoneal Neoplasms, Respiratory Tract Neoplasms, Smoking, Time Factors, United States, Occupational Exposure, Sex Distribution
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