Is there a relationship between joint hypermobility and gastrointestinal disorders in children?
Open accessAbstract
Background. The main aim of the study was to assess the association between joint hypermobility (JH) and gastrointestinal (GI) disorders in children. Methods. All children aged 4-17 years attending the clinics of the participating Pediatric Gastroenterology Centres for functional GI disorders (FGIDs) and inflammatory bowel disease (IBD) were screened for joint laxity. JH diagnosis was inferred using the Beighton Score. JHS diagnosis was inferred based on the Brighton Criteria. Rome III Diagnostic Criteria were used to diagnose possible FGIDs. Ulcerative colitis and Crohn`s disease diagnoses were made according to the Porto Criteria. Age and sex- matched healthy children were enrolled as controls. Results. One-hundred-seventy children with GI disorders (70 with FGIDs, 50 with Crohn`s disease, and 50 with ulcerative colitis) and 100 healthy controls were enrolled in the study. JH was reported in 7/70 (10%) children with FGIDs (p=0.26 compared to controls), 4/50 (8%) children with Crohn`s disease (p=0.21 compared to controls) and 15/50 (30%) children with ulcerative colitis (p=0.09 compared to controls; p=0.01 compared to FGIDs; p=0.01 compared to Crohn`s). Conclusions. JH is more prevalent in patients suffering from ulcerative colitis compared to the healthy general population, yet the difference did not reach statistical significance. Likely, a proportion of children with ulcerative colitis and JH may show connective tissue abnormalities. However, whether JH can be considered a possible feature of pediatric GI disorders deserves further investigation.
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Pediatric studies of populations of children with FGID using the Beighton score ≥ 4 cut off in the literature have been negative or uncontrolled.
“Pediatric studies of populations of children with FGID using the Beighton score ≥ 4 cut off in the literature [33, 45–47] have been negative or uncontrolled.”
From Pediatric joint hypermobility: a diagnostic framework and narrative review (2023) · cites this paper as [45]
The Methods and Results describe a controlled pediatric FGID study with no statistically significant difference in joint hypermobility versus healthy controls (7/70; p=0.26). However, the Methods and Table I specify a Beighton score >4, not the claimed ≥4 cutoff. Our copy gives no basis for classifying the other cited studies. (LLM, conf=0.88)
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Cites
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Pediatric joint hypermobility: a diagnostic framework and narrative review
Tofts, L. J., Simmonds, J., Schwartz, S. B., Richheimer, R. M., O’Connor, C., Elias, E., Engelbert, R., Cleary, K., Tinkle, B. T., Kline, A. D., et al. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02717-2 · Cited by 74 · see citing works
- Authors
- Quitadamo, P., Thapar, N., Nardo, G. D., Pescarin, M., Bertelli, L., Tortora, C., Borrelli, O., Giorgio, R. D., & Staiano, A.
- Affiliations
- Santobono Children's Hospital (IT)
- Great Ormond Street Hospital (GB)
- Azienda Ospedaliera Sant'Andrea (IT)
- University of Padua (IT)
- University of Naples Federico II (IT)
- University of Ferrara (IT)
- Corresponding author
- Quitadamo, Paolo
- ORCID
- Venue
- The Turkish Journal of Pediatrics
- Published
- 2021-04-25
- Volume
- 63
- Issue
- 2
- Pages
- 307-313
- ISSN
- 0041-4301 (ISSN-L)
- 2791-6421
- OpenAlex
- W3157288297
- Cited by
- 5
- References
- 7
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 3
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- The Turkish Journal of Pediatrics (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- joint hypermobility, gastrointestinal diseases, functional gastrointestinal disorders, inflammatory bowel disease, ulcerative colitis, Crohn's disease, children, Beighton score, Brighton criteria, connective tissue abnormalities
- MeSH terms
- Child, Colitis, Ulcerative, Crohn Disease, Gastrointestinal Diseases, Humans, Joint Instability, Prevalence
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