Joint Hypermobility: A Common Association with Complex Functional Gastrointestinal Disorders

Kovacic, Katja; Chelimsky, Thomas C.; Sood, Manu R.; Simpson, Pippa; Nugent, Melodee; Chelimsky, Gisela

doi:10.1016/j.jpeds.2014.07.021

Cited by 67Gastrointestinal motility and disordersConnective tissue disorders researchFibromyalgia and Chronic Fatigue Syndrome Research

Joint Hypermobility: A Common Association with Complex Functional Gastrointestinal Disorders

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Kovacic, Katja, Chelimsky, Thomas C., Sood, Manu R., Simpson, Pippa, Nugent, Melodee, Chelimsky, Gisela·2014·The Journal of Pediatrics

DOI 10.1016/j.jpeds.2014.07.021

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Abstract

Objective To evaluate the prevalence of joint hypermobility (JH) and comorbid conditions in children and young adults referred to a tertiary care neurogastroenterology and autonomic disorders clinic for functional gastrointestinal complaints. Study design This was a retrospective chart review of 66 new patients aged 5-24 years who fulfilled at least 1 pediatric Rome III criteria for a functional gastrointestinal disorder (FGID) and had a recorded Beighton score (n = 45) or fibromyalgia tender point score (n = 45) based on physician examination. Comorbid symptoms were collected and autonomic testing was performed for evaluation of postural tachycardia syndrome (POTS). Results The median patient age was 15 years (range, 5-24 years), 48 (73%) were females, and 56% had JH, a significantly higher rate compared with population studies of healthy adolescents (P < .001; OR, 10.03; 95% CI, 5.26-19.13). POTS was diagnosed in 34% of patients and did not correlate significantly with hypermobility. Comorbid conditions were common, including sleep disturbances (77%), chronic fatigue (93%), dizziness (94%), migraines (94%), chronic nausea (93%), and fibromyalgia (24%). Conclusion JH and other comorbid symptoms, including fibromyalgia, occur commonly in children and young adults with complex FGIDs. POTS is prevalent in FGIDs but is not associated with hypermobility. We recommend screening patients with complex FGIDs for JH, fibromyalgia, and comorbid symptoms such as sleep disturbances, migraines, and autonomic dysfunction.

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Pediatric studies of populations of children with FGID using the Beighton score ≥ 4 cut off in the literature have been negative or uncontrolled.
“Pediatric studies of populations of children with FGID using the Beighton score ≥ 4 cut off in the literature [33, 45–47] have been negative or uncontrolled.”
From Pediatric joint hypermobility: a diagnostic framework and narrative review (2023) · cites this paper as [33]
The Methods describe a retrospective FGID cohort assessed with a Beighton cutoff of ≥4, without a separately recruited control group. But the Methods and JH and FGIDs section report a comparison with previously studied healthy adolescents and a significantly higher hypermobility rate in the FGID children. Thus this study was not negative, and calling it simply uncontrolled omits its population-control comparison; our copy does not establish the status of the other cited studies. Page numbers are unavailable in our copy. (LLM, conf=0.82)
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Authors: Kovacic, K., Chelimsky, T. C., Sood, M. R., Simpson, P., Nugent, M., & Chelimsky, G.
Affiliations: Medical College of Wisconsin (US)
ORCID: Kovacic, Katja
Chelimsky, Thomas C.
Sood, Manu R.
Simpson, Pippa
Chelimsky, Gisela
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 2014-11
Volume: 165
Issue: 5
Pages: 973-978
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/j.jpeds.2014.07.021
OpenAlex: W1993288636
Cited by: 67
References: 42
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 1
FWCI: 6.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords: joint hypermobility, functional gastrointestinal disorders, postural orthostatic tachycardia syndrome, fibromyalgia, comorbidities, Beighton score, autonomic dysfunction, sleep disorders, chronic fatigue, migraine, children and young adults, neurogastroenterology
MeSH terms: Adolescent, Adult, Child, Child, Preschool, Cross-Sectional Studies, Female, Gastrointestinal Diseases, Humans, Joint Instability, Male, Retrospective Studies, Wisconsin, Comorbidity, Prevalence, Young Adult

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Joint Hypermobility: A Common Association with Complex Functional Gastrointestinal Disorders

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