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300IR 5-Grass Pollen Sublingual Tablet Offers Relief from Nasal Symptoms in Patients with Allergic Rhinitis
Abstract
Background 300IR 5-grass pollen sublingual immunotherapy tablets have been approved for the treatment of allergic rhinitis (AR) with or without conjunctivitis in adults and children >5 years with grass pollen allergy. This study was designed to review data on nasal symptoms with 300IR 5-grass pollen sublingual tablets in adults and children. Methods We reviewed data from four double-blind, placebo-controlled, randomized clinical trials. Two groups of patients who received a daily dose of either placebo or 300IR 5-grass pollen sublingual tablets starting 4 months before the expected start of the pollen season and continuing through the season were compared (analysis of covariance) for scores of sneezing, rhinorrhea, nasal pruritus, nasal congestion, total nasal symptom score (TNSS), and adult Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores. Results Data for 266 children (one pediatric trial) and 1036 adults (three trials) were analyzed. Compared with the placebo groups, mean TNSS in the 300IR groups was lower by 22% in children and 19-36% in adults. Among the four nasal symptoms, the lowest scores relative to placebo were for nasal congestion in children (31%) and adults (43%). Mean adult RQLQ scores were 21-31% lower in the 300IR group than in the placebo group. Conclusion Allergen immunotherapy with 300IR 5-grass pollen sublingual tablets was consistently associated with AR symptom relief in adults and children and provided a clinically meaningful improvement…
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Grass pollen tablets administered in a pre/coseasonal pattern reduce symptoms compared with placebo in children (31%) and adults (43%) with allergic rhinitis.
“In a review of clinical trials conducted using grass pollen tablets in a pre/coseasonal pattern, a reduction was observed compared with placebo in children (31%) and adults (43%) with AR [175].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [175]
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Position Paper on Nasal Obstruction: Evaluation and Treatment
SEAIC Rhinoconjunctivitis Committee & SEORL Rhinology, A., Valero, A., Navarro, A., del Cuvillo, A., Alobid, I., Benito, Jr., Colás, C., de los Santos, G., Fernández Liesa, R., García-Lliberós, A., et al. (2018) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0232 · Cited by 76
Metadata
- Authors
- Serrano, E., Wahn, H. U., Didier, A., & Bachert, C.
- Affiliations
- Ear, Nose and Throat Department, Larrey Hospital, Toulouse, France
- Charité – Universitätsmedizin Berlin (DE)
- Hôpital Larrey (FR)
- Ghent University Hospital (BE)
- Venue
- American Journal of Rhinology & Allergy
- Publisher
- SAGE Publications
- Published
- 2014-11
- Volume
- 28
- Issue
- 6
- Pages
- 471-476
- ISSN
- 1945-8924 (ISSN-L)
- 1945-8932
- OpenAlex
- W2330246833
- Cited by
- 7
- References
- 3
- Citations by year
- 2022: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Rhinology and Allergy (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- sublingual immunotherapy, grass pollen allergy, allergic rhinitis, nasal symptoms, rhinorrhea, nasal congestion, sneezing, nasal pruritus, Rhinoconjunctivitis Quality of Life Questionnaire, quality of life, children, adults
- MeSH terms
- Administration, Sublingual, Adult, Allergens, Child, Conjunctivitis, Desensitization, Immunologic, Female, Poaceae, Rhinitis, Allergic, Seasonal, Humans, Male, Pollen, Quality of Life, Tablets, Randomized Controlled Trials as Topic
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