Allergen-Specific Immunoglobulin E and Allergic Rhinitis Severity
Open accessAbstract
Background: Allergic rhinitis (AR) is a common disorder. The diagnosis is based on the concordance between allergy sensitization and history. Serum allergen specific immunoglobulin E (sIgE) assessment allows characterization of the relevant sensitizing allergens. Presently, Allergic Rhinitis and its Impact on Asthma (ARIA) classification subdivides AR based on symptoms severity and duration. However, the relationship between sIgE levels and symptom severity is still a matter of debate. Objective: Therefore, this study aimed at relating sIgE levels with symptom severity assessed by ARIA classification in a group of patients with AR. Methods: We enrolled 217 patients with AR (123 women; median age, 39.5 years). The sIgE levels (expressed in kUA/L) to house-dust mite were detected by the fluorescence enzyme immunoassay in peripheral blood samples. The IgE calibrators were traceable to the second international reference preparation 75/502 of human serum IgE from the World Health Organization. Symptom severity was assessed by ARIA classification. Results: We found a significant difference in sIgE levels in patients with mild intermittent versus mild persistent symptoms (p < 0.05), mild intermittent versus moderate-to-severe persistent symptoms (p < 0.001), moderate-to-severe intermittent versus moderate-to-severe persistent symptoms (p < 0.01), and mild persistent versus moderate-to-severe persistent symptoms (p < 0.05). Conclusion: Analysis of these findings indicated that the sIgE level to house-dust mite might be a reliable biomarker for symptom severity in patients with AR. This outcome might be clinically relevant, particularly in candidates for immunotherapy.
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Specific IgE may help in selecting candidates for AIT and possibly predict response.
“sIgE may help in the selection of candidates for AIT and possibly predict the response.919,924”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [919]
The Discussion says high sIgE levels might help identify patients with the best indication for allergen immunotherapy, supporting the candidate-selection point. It also says the relationship between sIgE level and symptom improvement with immunotherapy still needs to be studied, so it does not establish sIgE as a predictor of treatment response. (LLM, conf=0.85)
Experimental — accuracy not yet measuredPatients with more severe symptoms have been shown to respond better to AIT than those with milder symptoms.
“Given that patients with more severe symptoms have been shown to respond better to AIT than those with milder symptoms, sIgE may help in the selection of candidates for AIT and possibly predict the response.919,924”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [919]
Levels of specific IgE may correlate with severity of allergic rhinitis symptoms.
“A second application lies in the fact that levels of sIgE may correlate with severity of AR symptoms.919-923”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [919]
Experimental — accuracy not yet measured
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Cites
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729 · see citing works
Association of Asthma with Serum IgE Levels and Skin-Test Reactivity to Allergens
Burrows, B., Martínez, F. D., Halonen, M. J., Barbee, R. A., & Cline, M. G. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200502 · Cited by 1,656 · see citing works
Epidemiological characterization of the intermittent and persistent types of allergic rhinitis
Bauchau, V., & Durham, S. R. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00751.x · Cited by 250 · see citing works
Executive Summary of Joint Task Force Practice Parameters on Diagnosis and Management of Rhinitis
Dykewicz, M. S., & Fìneman, S. M. (1998) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63152-3 · Cited by 249 · see citing works
A comparison of skin prick tests, intradermal skin tests, and RASTs in the diagnosis of cat allergy
Wood, R. A., Phipatanakul, W., Hamilton, R. G., & Eggleston, P. A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70419-7 · Cited by 201 · see citing works
Sastre, J., Landivar, M. E., Ruiz-García, M., Andregnette, M., & Mahíllo, I. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02808.x · Cited by 198 · see citing works
Didier, A. P., Worm, M., Horak, F., Sussman, G. L., de Beaumont, O., Gall, M. L., Mélac, M., & Malling, H. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.022 · Cited by 164 · see citing works
Verlato, G., Corsico, A. G., Villani, S., Cerveri, I., Migliore, E., Accordini, S., Carolei, A., Piccioni, P., Bugiani, M., Cascio, V. L., et al. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1484 · Cited by 161 · see citing works
Self-citationCharacterization and comparison of commercially available mite extracts for in vivo diagnosis
Brunetto, B., Tinghino, R., Braschi, M. C., Antonicelli, L., Pini, C., & Iacovacci, P. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02150.x · Cited by 103 · see citing works
Relationship between serum IgE and airway responsiveness in adults with asthma
Sunyer, J., Antó, J. M., Sabriá, J., Roca, J., Morell, F., Rodriguez‐Roisin, R., & Rodrigo, M.-J. (1995) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(95)70175-3 · Cited by 99 · see citing works
Siroux, V., Oryszczyn, M., Paty, E., Kauffmann, F., Pison, C. M., VERVLOET, D., & Pin, I. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01674.x · Cited by 92 · see citing works
Serum IgE levels, atopy, and asthma in young adults: results from a longitudinal cohort study
PEAT, J. K., Toelle, B. G., Dermand, J. C., Berg, R., Britton, W. J., & Woolcock, A. J. (1996) · Allergy · doi:10.1111/j.1398-9995.1996.tb00026.x · Cited by 86 · see citing works
Howarth, P., Malling, H. ‐., Molimard, M., & Devillier, P. (2012) · Allergy · doi:10.1111/j.1398-9995.2011.02759.x · Cited by 61 · see citing works
(2006) · PubMed · Cited by 56 · see citing works
Serum IgE levels, atopy, and asthma in young adults: results from a longitudinal cohort study
PEAT, J. K., Toeile, B. G., Dermand, J. C., et al. (1996) · Allergy · doi:10.1111/j.1398-9995.1996.tb04470.x · Cited by 56 · see citing works
Sharma, H. P., Wood, R. A., Bravo, A. R., & Matsui, E. C. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.01.023 · Cited by 52 · see citing works
Rolinck‐Werninghaus, C., Keil, T. O. P., Kopp, M., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01692.x · Cited by 36 · see citing works
Ciprandi, G., Comite, P., Ferrero, F., Bignardi, D., Minale, P., Voltolini, S., Troise, C., & Mussap, M. (2016) · Allergy and Asthma Proceedings · doi:10.2500/aap.2016.37.3914 · Cited by 34 · see citing works
Self-citationSilvestri, M., Oddera, S., Crimi, P., et al. (1997) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63058-x · Cited by 25 · see citing works
Цыбиков, Н. Н., Egorova, E. V., Bi, K., et al. (2016) · Allergy and Asthma Proceedings · doi:10.2500/aap.2016.37.3899 · Cited by 25 · see citing works
Patelis, A., Gunnbjörnsdóttir, M., Alving, K., Borres, M. P., Högman, M., Janson, C., & Malinovschi, A. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12607 · Cited by 24 · see citing works
Shadick, N. A., Sparrow, D., O’Connor, G. T., et al. (1996) · Thorax · doi:10.1136/thx.51.8.787 · Cited by 23 · see citing works
Diverging trends of chronic bronchitis and smoking habits between 1998 and 2010
Accordini, S., Corsico, A. G., Cerveri, I., Antonicelli, L., Attena, F., Bono, R., Casali, L., Ferrari, M., Fois, A. G., Marchetti, P., et al. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-16 · Cited by 22 · see citing works
Self-citationComparison of Serum Specific IgE and Skin Prick Test in Polysensitized Patients
Ciprandi, G., De Amici, M., Giunta, V., & Marseglia, G. L. (2010) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201002300438 · Cited by 22 · see citing works
Self-citationDoes the Profile of Sensitization to Grass Pollen Allergens Have Clinical Relevance?
Palao, P., Domínguez‐Ortega, J., Barranco, P., Díaz‐Almirón, M., & Quirce, S. (2016) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0043 · Cited by 14 · see citing works
Serum allergen-specific IgE, allergic rhinitis severity, and age
Ciprandi, G., Comite, P., Ferrero, F., Fontana, V., Bruzzone, M., & Mussap, M. (2017) · Rhinology journal · doi:10.4193/rhin15.300 · Cited by 14 · see citing works
Self-citationMethodological aspects of a meta-analysis of grass pollen allergen sublingual immunotherapy tablets
Cox, L., Didier, A., Demoly, P. M., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.01.039 · Cited by 9 · see citing works
The diagnostic performance of allergen-molecules in comparison to allergen-extracts
van der Linden, I. J. M., de Groot, M. J. M., de Jong, N., Bozkurt, Z., & Cobbaert, C. M. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.729 · Cited by 6 · see citing works
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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works
Self-citation
- Authors
- Corsico, A. G., De Amici, M., Ronzoni, V., Giunta, V., Mennitti, M. C., Viscardi, A., Marseglia, G. L., & Ciprandi, G.
- Affiliations
- Policlinico San Matteo Fondazione (IT)
- Pediatric Clinic, Fondazione IRCCS San Matteo, Pavia, Italy
- Ospedale Policlinico San Martino (IT)
- Corresponding author
- Ciprandi, Giorgio
- Venue
- Allergy & Rhinology
- Publisher
- SAGE Publications
- Published
- 2017-01
- Volume
- 8
- Issue
- 1
- Pages
- 1-4
- ISSN
- 2152-6567 (ISSN-L)
- 2152-6575
- PMC
- PMC5380446
- OpenAlex
- W2604511299
- Cited by
- 59
- References
- 28
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 2 · 2013: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Allergy & Rhinology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- allergic rhinitis, house dust mites, symptom severity, ARIA classification, biomarkers, allergen sensitization
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