Aerobic Exercise Alters Analgesia and Neurotrophin-3 Synthesis in an Animal Model of Chronic Widespread Pain
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Background Present literature and clinical practice provide strong support for the use of aerobic exercise in reducing pain and improving function for individuals with chronic musculoskeletal pain syndromes. However, the molecular basis for the positive actions of exercise remains poorly understood. Recent studies suggest that neurotrophin-3 (NT-3) may act in an analgesic fashion in various pain states. Objective The purpose of the present study was to examine the effects of moderate-intensity aerobic exercise on pain-like behavior and NT-3 in an animal model of widespread pain. Design This was a repeated-measures, observational cross-sectional study. Methods Forty female mice were injected with either normal (pH 7.2; n=20) or acidic (pH 4.0; n=20) saline in the gastrocnemius muscle to induce widespread hyperalgesia and exercised for 3 weeks. Cutaneous (von Frey monofilament) and muscular (forceps compression) mechanical sensitivity were assessed. Neurotrophin-3 was quantified in 2 hind-limb skeletal muscles for both messenger RNA (mRNA) and protein levels after exercise training. Data were analyzed with 2-factor analysis of variance for repeated measures (group x time). Results Moderate-intensity aerobic exercise reduced cutaneous and deep tissue hyperalgesia induced by acidic saline and stimulated NT-3 synthesis in skeletal muscle. The increase in NT-3 was more pronounced at the protein level compared with mRNA expression. In addition, the increase in NT-3 protein was signi…
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General aerobic exercises have been shown to improve muscle strength, flexibility, and functional capacity and could induce analgesia.
“General aerobic exercises have been shown to improve muscle strength, flexibility, and functional capacity and could induce analgesia.107”
From Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis (2016) · cites this paper as [107]
Exercise training has been suggested to reduce pain but not cure the source of pain, and sufficient publications to verify the claim do not exist.
“Exercise training has been long suggested to reduce pain, but not to be a cure to the source of the pain [see (469) for refs.], but sufficient publications to verify the claim do not exist.”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [469]
Moderate-intensity aerobic exercise reduced cutaneous and deep tissue hyperalgesia induced by acidic saline and stimulated neurotrophic factor-3 synthesis in gastrocnemius but not soleus muscle.
“Moderate-intensity aerobic exercise reduced cutaneous and deep tissue hyperalgesia induced by acidic saline and stimulated neurotrophic factor-3 synthesis in gastrocnemius but not the soleus muscle (469).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [469]
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References 57 · Cited by 73
- Authors
- Sharma, N. K., Ryals, J. M., Gajewski, B. J., & Wright, D. E.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Sharma, Neena K.
- Venue
- Physical Therapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05-01
- Volume
- 90
- Issue
- 5
- Pages
- 714-725
- ISSN
- 0031-9023 (ISSN-L)
- 1538-6724
- PMC
- PMC3171655
- OpenAlex
- W2160920727
- Cited by
- 73
- References
- 57
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physical Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R43CA094404)
- National Institute of Neurological Disorders and Stroke (R01NS043314)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- aerobic exercise, neurotrophin-3, chronic widespread pain, hyperalgesia, analgesia, exercise training, gastrocnemius, soleus muscle, mechanical hyperalgesia, cutaneous hyperalgesia, skeletal muscle
- MeSH terms
- Analysis of Variance, Animals, Chronic Disease, Cross-Sectional Studies, Disease Models, Animal, Female, Hyperalgesia, Pain, Physical Conditioning, Animal, Random Allocation, RNA, Messenger, Muscle, Skeletal, Neurotrophin 3, Mice
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