Relationships of gonadotropins, testosterone, and cortisol in response to GnRH and GnRH antagonist in boars selected for high and low follicle-stimulating hormone levels.
Abstract
Considerable variation exists in the serum levels of gonadotropins in boars; this results in differential testicular function. Boars (Chinese Meishan, European White composite, and crosses of the two breeds) selected for high and low circulating FSH concentrations were used to define possible differences in pituitary sensitivity to GnRH and GnRH antagonist and gonadal and adrenal responses. After a 2-h pretreatment sampling period, boars were injected with GnRH or GnRH antagonist and repetitively sampled via jugular cannula for changes in serum concentrations of FSH, LH, testosterone, and cortisol. In response to varying doses of GnRH or GnRH antagonist, FSH, LH, or testosterone changes were not different in high- or low-FSH boars. Declines in LH after GnRH stimulation were consistently faster in boars selected for high FSH. Chinese Meishan boars had considerably higher cortisol concentrations than White composite boars (132.2 +/- 28.5 vs 67.4 +/- 26.8 ng/mL, respectively; P < .01). When select high- and low-gonadotropin Meishan:White composite crossbreds were sampled, cortisol levels were elevated but comparable between the two groups (126.5 +/- 13.7 vs 131.4 +/- 13.4 ng/mL, respectively). After GnRH antagonist lowered LH concentrations, administration of hCG resulted in increased testosterone and cortisol concentrations. Although testosterone concentrations remained high for 30 h, cortisol concentrations returned to normal levels within 10 h after hCG injection. The mechanism by which boars selected for high gonadotropins achieve increased levels of LH and FSH may not be due to differences in pituitary sensitivity to GnRH but to differences in clearance from the circulation.
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In boars, increased serum concentrations of GnRH result in higher levels of testosterone.
“In boars, it has been observed that increased serum concentrations of GnRH result in higher levels of testosterone [51].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [51]
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Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle
Eusebi, P. G., Sevane, N., O’Rourke, T., Pizarro, M., Boeckx, C., & Dunner, S. (2021) · BMC Genomics · doi:10.1186/s12864-021-07505-5 · Cited by 24 · see citing works
- Authors
- Wise, T., Zanella, E. L., Lunstra, D. D., & Ford, J. J.
- Affiliations
- Agricultural Research Service (US)
- University of Nebraska–Lincoln (US)
- Corresponding author
- Wise, T
- ORCID
- Zanella, E L
- Venue
- Journal of Animal Science
- Publisher
- Oxford University Press (OUP)
- Published
- 2000
- Volume
- 78
- Issue
- 6
- Pages
- 1577
- ISSN
- 0021-8812 (ISSN-L)
- OpenAlex
- W2409358974
- Cited by
- 21
- References
- 37
- Citations by year
- 2021: 3 · 2020: 1 · 2017: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Animal Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- gonadotropins, follicle-stimulating hormone, luteinizing hormone, testosterone, cortisol, gonadotropin-releasing hormone, GnRH antagonist, boars, crossbred pigs, pituitary sensitivity, human chorionic gonadotropin, testicular function
- MeSH terms
- Animals, Follicle Stimulating Hormone, Gonadotropins, Chorionic Gonadotropin, Hormone Antagonists, Hydrocortisone, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Swine, Testosterone
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