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The Design of Organometallic Ruthenium Arene Anticancer Agents
Open accessAbstract
Organometallic half-sandwich RuII anticancer complexes of the type [(?6-arene)Ru(YZ)X]n can exhibit interesting anticancer activity. We review the comparative aqueous solution chemistry (hydrolysis rates, pKa values of aqua complexes), cancer cell cytotoxicities, cross-resistance, reactivity towards nucleobases, DNA and important biomolecules for complexes containing various arenes, N,N- or N,O- or O,O-chelating ligands as YZ, and monodentate leaving groups X. We show that the choice of these ligands can have a dramatic effect on reactivity. The same is true for analogous OsII arene complexes. The interpretation of structure–activity relationships requires an understanding of reactions of these organometallic complexes under biological test conditions.
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Cited by
Organometallic Anticancer Compounds
Gasser, G., Ott, I., & Metzler-Nolte, N. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm100020w · Cited by 1,624
Zeng, L., Gupta, P., Chen, Y., Wang, E., Ji, L., Chao, H., & Chen, Z.-S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00195a · Cited by 1,017
Recent developments in ruthenium anticancer drugs
Levina, A., Mitra, A., & Lay, P. A. (2009) · Metallomics · doi:10.1039/b904071d · Cited by 592
Photoactivated Biological Activity of Transition‐Metal Complexes
Schatzschneider, U. (2010) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.201000003 · Cited by 349
Pierroz, V., Joshi, T., Leonidova, A., Mari, C., Schur, J., Ott, I., Spiccia, L., Ferrari, S., & Gasser, G. (2012) · Journal of the American Chemical Society · doi:10.1021/ja307288s · Cited by 296
Metadata
- Authors
- Dougan, S. J., & Sadler, P. J.
- Venue
- CHIMIA
- Publisher
- Swiss Chemical Society
- Published
- 2007-11-28
- Volume
- 61
- Issue
- 11
- Pages
- 704
- ISSN
- 0009-4293 (ISSN-L)
- 2673-2424
- OpenAlex
- W2003575529
- Cited by
- 202
- References
- 0
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- diamond
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