The role of toll-like receptors in macrophages
Open accessAbstract
Macrophages play diverse roles including but not limited to homeostatic clearance, detection of invading pathogens and induction of the adaptive immune response. Since their discovery, it has become clear that Toll-like receptors (TLRs) can play a major role in these macrophage functions. This review will describe the TLRs, their signalling pathways and their role in macrophage function.
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TIR-like proteins, among which are Toll receptors, are major regulators of phagocytosis and pathogen-response in animals.
“TIR-like proteins, among which are Toll receptors, are major regulators of phagocytosis and pathogen-response in animals [54,66-68].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [67]
Cites
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442 · see citing works
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Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
Sierra, A., Abiega, O., Shahraz, A., & Neumann, H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00006 · Cited by 574 · see citing works
Bacterial contamination hypothesis: a new concept in endometriosis
Khan, K. N., Fujishita, A., Hiraki, K., Kitajima, M., Nakashima, M., Fushiki, S., & Kitawaki, J. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12083 · Cited by 176 · see citing works
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Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium
Sillo, A., Bloomfield, G., Balest, A., Balbo, A., Pergolizzi, B., Peracino, B., Skelton, J., Ivens, A., & Bozzaro, S. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-291 · Cited by 69 · see citing works
- Authors
- McCoy, C.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- McCoy, Claire, E.
- ORCID
- McCoy, Claire, E.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2008
- Volume
- 13
- Issue
- 13
- Pages
- 62
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/2660
- OpenAlex
- W1484335948
- Cited by
- 69
- References
- 1
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 9 · 2012: 4
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- Toll-like receptors, macrophages, innate immunity, pathogen detection, adaptive immune response, host defense
- MeSH terms
- Animals, Homeostasis, Humans, Immune System, Inflammation, Macrophages, Models, Biological, Phagocytosis, Phagosomes, Antigen Presentation, Toll-Like Receptors
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